Here is a copy of my letter, I think it is important to show them that we have done our homework and we are not just talking about one small clinical trial anymore.
Attn: THE PARLIAMENTARY SUB COMMITTEE ON NEUROLOGICAL HEALTH
Re: Chronic Cerebrospinal Venous Stenosis (CCSVI) and Multiple Sclerosis
C/O Ms. Christine Holke David
Historically vague associations linking the cerebral and spinal venous system to Multiple Sclerosis have been found. In fact researchers as far back as 1930 have speculated as to the potential involvement of the venous system in the formation of cerebral and spinal plaques known to occur in Multiple Sclerosis.
In more recent times a number of studies are beginning to come to light that once again draw attention to the possible link between the venous system and Multiple Sclerosis.
-Drs Marre, et al in a study recently completed in Winnipeg found that vascular comorbidities are linked to increased disability in MS patients. PMID: 20350978
-Drs. Prineas and Barnett released a paper detailing histopathological work where they found that immune system involvement is not apparent in early stages of lesion formation and speculated that build up of a toxic substance(s) (which could be due to poor venous flow) in the cerebrospinal veins could be linked to plaque formation. They suggested that the current immunological theory of MS causation may need to be amended. PMID: 15048884
-Drs. Zivadinov, Zamboni, and others are compiling research showing a strong correlation between MS and chronic cerebrospinal venous insufficiency a condition recognised by the International uni0n of Phlebology. PMID: 20351672, PMID: 19958985 http://www.phlebology.org/meetings/international.html
-De Keyser, et al have found that the early formation of plaques that occur in Multiple Sclerosis appear to be consistent with hypoxic tissue injury, likely due to poor venous flow. PMID: 18594554
-The country of Kuwait has gone so far as to institute a nationwide trial of CCSVI and its potential benefits to Kuwaiti citizens suffering from Multiple Sclerosis. http://www.ccsvikuwait.com/
-Finally, a growing international group of interventional radiologists, albeit in early stages of research as of yet, are finding promising results in the exploration of treating venous stenosis as described in Dr. Zamboni’s work on CCSVI theory and are actively pursuing clinical trials. Some of the doctors engaging in this rapidly growing body of work are: Dr. Dake, Chief of Interventional Radiology, Stanford University, California; Dr. Sclafani, Chief of Radiology, Kings County Hospital, New York; Dr. Bonn, Pennsylvania; Dr. Mehta, Albany, NY; Dr. Simka, Poland; Drs. Kim and Kabutey, Boston just to name just a few.
While this line of research may seem to be new, I believe it to be the result of a long line of investigations, too numerous to be fully detailed here. For this reason, as someone suffering from Multiple Sclerosis, I feel it is appropriate and I beseech the Government of Canada to release funding in aid of Canadian investigations of this theory in an effort to shed new light on this complex and baffling disease.
Thank you for your time and consideration of this matter.