The present study analyses autopsy material from five multiple sclerosis patients who received autologous stem cell transplantation. A total of 53 white matter lesions were investigated using routine and immunohistochemical stainings to characterize the demyelinating activity, inflammatory infiltrates, acutely damaged axons and macrophages/microglial cells. We found evidence for ongoing active demyelination in all of the five patients. The inflammatory infiltrate within the lesions showed only very few T cells and CD8+ cytotoxic T cells dominated the T cell population. B cells and plasma cells were completely absent from the lesions. High numbers of acutely damaged axons were found in active lesion areas. Tissue injury was associated with activated macrophages/microglial cells.The present results indicate that ongoing demyelination and axonal degeneration exist despite pronounced immunosuppression. Our data parallel results from some of the clinical phase I/II studies showing continued clinical disease progression in multiple sclerosis patients with high expanded disability system scores despite autologous stem cell transplantation.
http://brain.oxfordjournals.org/cgi/con ... 130/5/1254
This is a study. It is science. It is not my opinion. The doctors tested the brains of five MS patients who had received this treatment. The treatment Dr. Freedman has received 4 million dollars to study. The treatment we are talking about on this thread. Upon autopsy, the treatment HAD NOT STOPPED MS(demyelination or neurodegeneration) in ONE SINGLE PATIENT tested.
There is nothing personal here. It is just fact.