Cece wrote:frodo wrote:The only ethically possible way to have controls is to use the restenosis cases as such.
I think however that everyone who feels better and then restenoses is immediately aware of feeling worse and quite desperate to get the procedure done again.
se1956 wrote:1st step:
50% liberation - 50% get a placebo liberation
I still don't know how one could possibly do a placebo liberation
NZer1 wrote:I believe that the restenosis that the patient notices is some of the key here
NZer1 wrote: It indicates that placebo doesn't currently exist and retesting will support that.
NZer1 wrote: This is also proof that the treatment works if the patient knows they have regressed.
If the changes that treatment made can be measured then you have a tool for overcoming the placebo debate.
NZer1 wrote: Now taking the opposite angle, could the symptoms be recreated in another patient who is CCSVI free. That is to say to recreate the same style/type of stenosis that on the treatment table created immediate improvements for a CCSVI treated patient.
This may open a nest of possibilities and provide some insights. It most likely will show the variety of outcome that the blocked veins can create and the effects of time will be even more interesting.
MarkW wrote:CCSVI and MS are difficult to study as RRMS varies in an untreated but statistically normal MS population.
Also we need to find a short term change after de-stenosis, maybe look at 'purple feet' and measure temperature or blood flow. Fatigue is measurable, using techniques employed by Clinical Psychologists for investigating Chronic Fatigue Syndrome.
Interesting topic, it requires some 'outside the box' thinking.
fogdweller wrote:Billmeik wrote:I guess if the patients were under full sedation during the angio?
You would also have to make an incision. I think the risk, even slight, of placing a patient under anesthesia and making an incision when you know you are not going to treat would be unethical.
However, I am not sure. Could informed consent allow this? If so that could be an anwer!!
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