How can we design a trial to test efficacy of the surgery?

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Postby Fernie12 » Sun May 23, 2010 9:16 am

I have been following this thread since inception. One thing I couldn't get past was the "ethics" of pretending to perform a procedure. This is no a sugar pill. We'd have to "pretend" to intervene in a patient's stenosis.

Gawd, wish this was the 80s! Oh, right...no one listened to the messenger then or we'd all have had this procedure the day after our diagnosis! LOL

Check it out:
http://jrsm.rsmjournals.com/cgi/content/full/97/12/576
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Cross over trials

Postby MarkW » Sun May 23, 2010 12:17 pm

I have not noticed anyone mention cross over trials for CCSVI. They are used in early stage clinical trials. You should be able to find lots on info on the dear old www.
Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Postby fogdweller » Thu May 27, 2010 1:55 pm

jsut a quick note to reactivate this thread since a few of us spun off-topic on another thread talking about placebo effects and need to have a place to discuss this.

Eric593, you make a valid point that a placebo in place of warfarin might have just as much anti-clotting effect, but I doubt it. Do you have any information one way or the other about this kind of pysciological effect and placebo? Clotting is a chemical reaction, and without one of the chemicals, it does not take place as effectively. I don't think a placebo would have this same effect. It strikes me as different-in- kind compared to the side effects of pain, or flu-like symptoms.
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