This is from a meta-analysis of studies using placebos on people with MS:
Does a placebo-effect exist in clinical trials on multiple sclerosis? Review of the literature.http://www.ncbi.nlm.nih.gov/pubmed/8797067
La Mantia L, Eoli M, Salmaggi A, Milanese C.
Istituto Neurologico C. Besta, Milano, Italy.
To verify whether the outcome in placebo-treated MS patients actually corresponds to that expected on the basis of the natural history and pretrial evolution of the disease, we here review the results of clinical trials conducted according to a placebo-controlled, randomized design, regardless of the experimental therapy used. The frequency of relapse in remitting-relapsing patients decreases during follow-up, and disability in progressive cases increases more slowly than before enrollment. These data should be borne in mind when evaluating the impact of experimental drugs on the natural course of the disease.
Good find. My point, even objective factors are decreased per placebo. I was talking to a neuro who said that all the drug trials seemed to be about 35-40% reduction and he thought that might not be real. However those were double blind studies, so whatever their placebo effect, that could give us a number to use. (a placebo effect.)
Decrease of relapses and disability both sound like objectively measured things, so we're not just talking placebo/not real but placebo/has an objective effect, I think.