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Microvascular Abnormality in Relapsing-Remitting Multiple Sclerosis: Perfusion MR Imaging Findings in Normal-appearing White Matter1
Meng Law, MD, Amit M. Saindane, MD, Yulin Ge, MD, James S. Babb, PhD, Glyn Johnson, PhD, Lois J. Mannon, RT, Joseph Herbert, MD and Robert I. Grossman, MD
- Author Affiliations

1From the Departments of Radiology (M.L., A.M.S., Y.G., J.S.B., G.J., L.J.M., R.I.G.) and Neurology (J.H.), New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Ave, New York, NY 10016. Received June 24, 2003; revision requested September 3; revision received October 16; accepted November 12. Supported by National Institutes of Health grants RO1CA093992, NS29029, NCRR M01 RR00096 GCRC, and R37 NS 29029–11. Address correspondence to M.L. (e-mail: lawm01@med.nyu.edu).


and this:

So do MSers have their symptoms provoked after a hot bath, exercise, food or alcohol intake because these are all things that vasodilate the extraneural vascular bed (?) and shunt vascular reserve away from the already underserved brain? I don't think so, I've understood vasodilation to be good for us, but I dunno?

I did a search for this article here and it does look like it was discussed in cheerleader's original long sticky, but I was not able to find where.

My other reason for posting this is that: these guys at New York University Medical Center should have been all over CCSVI, has anyone contacted them?

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"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition

I have read other papers as well by Yulin Ge. I think some of these
researchers presented papers in Toronto at the American Neurology conference? Lets hope they are big on CCSVI.

Hi Cece--Yes, people on here have been "all over" New York University--some of the MS patients from there found this paper and other research the neurologists there did with Dr. Mark Haacke in 7 Tesla MRI studies, and tried to talk about doing CCSVI testing, but the doctors were not interested in CCSVI studies. At all. THere's a thread on here somewhere where people were talking about demanding NYU get involved....but it's been buried and I'm too tired to find it.

This paper you've linked is all about hypoperfusion, and how that can create ischemia in the brain. Here it is....Marie found it in March '09 (you can search by posts, in order to find specific ones on longer threads....)

link


The vasodilitation mentioned is inside the brain-not good, since it takes vascular reserves away from an already slowly perfused brain....CCSVI patients want vasodilation outside the brain ...in the extracranial veins. It was this paper that confirmed to me what we saw when Jeff came home from a week at high altitude with his first MS flare...low oxygen further damaging an already injured brain, due to venous congestion and slowed perfusion.

here's a good thread on hypoperfusion.
http://www.thisisms.com/ftopict-7708-hypoperfusion.html

Dr. Hubbard is now testing fMRI BOLD (oxygenation levels) in CCSVI before and after angioplasty and finding a large change in oxygenation rates once veins are opened. more to come---

cheer

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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

I have had problems going for hot baths since I was young. I would get a sensation running through my body and then my head would feel weak almost like I was going to faint.

I just called it "a funny feeling" but it is making sense now.

_________________
<em>Badger
RRMS 2004</em>
Appt Katowice 23/24th March

I think the author is saying exactly what you think. According to him, vascodilation results in drawing of additional blood flow in extra neural network resulting in more starvation ...