smokey wrote:The association between occurence of MS and latitude (birth) is well documented. Is there anywhere on thisisms - I could have missed it, explaining the association between latitude (birth) and CCSVI?
Calcitriol was ....administered after acute exposure of rat cerebellar neurons to.... 7-day-old rat pups subjected to hypoxia-ischemia,
acute application of calcitriol....reduced brain damage.
The level of neuroprotection exceeded that achieved by hypoxic preconditioning used as the reference neuroprotective method.
Just my two cents here, but the Vitamin D deficiency in the pregnant mother seems to explain all of these associations. Especially knowing that CCSVI is congenital. The fact that Tokyo has a lower incidence than Melbourne could easily be explained by the fact that Japanese tend to eat much more Vitamin D rich foods (generally fish) than our friends down under. In addition, local weather patterns can influence Vitamin D deficiency (Scottland has more cloudy days than England, etc.).hwebb wrote:I recall reading that Tokyo, Japan has a similar latitude to Melbourne, Australia. However, in Melbourne the MS rate is high (approx 1 in 1000)...in Tokyo low (approx 1 in 10,000).
Interestingly, the rate in Scotland is approx 1 in 250. The rate in neighbouring England and Wales is approx 1 in 1000. However, if you live in England and have a scottish surname, the figures of those with MS are close to those of people actually living in Scotland.
So genetics plays a large role.
If only metabolism were important than the birthdate studies would not have shown such a drastic bias of spring birthdays for pwMS. Sun exposure for your mom during your pregnancy matters!hwebb wrote:So not so important how much sun you've seen, or even how much sun your mother has seen
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