The problem with the EAE model, Bill, is that in order to create it, you need to inject a foreign antigen into the body...so the assumption is that some foreign matter enters the CNS and creates this reaction.
In encephalomyelitis (a differential for MS)- the reaction of inflammation and demyelination is created by a virus or vaccine.
Putnams' dogs developed an encephalitic reaction (inflammatory/demyelination) that looked just like MS WITHOUT introducing any foreign matter....simply by blocking the cerebral veins. Ockham's Razor.
Why do we continue to use a model which needs that extra step of foreign matter injection into the CNS of animals? I think it's because immunologists can "cure" EAE....but it takes a VASCULAR doctor to stop venous reflux and congestion. Venous doctors have never studied MS...until now.
smokey wrote:Awwww, thought I might have been original.....never mind. Still a damn fine principle.
smokey wrote:Occam's razor (or Ockham's razor) is the principle that "entities must not be multiplied beyond necessity" (entia non sunt multiplicanda praeter necessitatem). The popular interpretation of this principle is that the simplest explanation is usually the correct one...........
LR1234 wrote:I reckon by this time next year CCSVI will be recognised as a treatable condition in every country.
1eye wrote:I have at times tried to make a list of countries where Liberation is allowed:
US (if not in a trial. otherwise IRB footdrag)
any other? I can't remember them all.
Occam's -- A great shave, every time...
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