This Is MS Multiple Sclerosis Community: Knowledge & Support

Interesting paper that discusses transport of iron in the brain-blood barrier-CSF.

The last quote on the main page is what makes CCSVI very real:



In short, the intake of iron into the brain is regulated and the efflux is by open flow. That makes for ideal conditions according to the authors.

So what happens if one or the other- or both?- are off?

If the receptors misfire, one could get too much iron intake (Parkinsons? Alzheimers?). Does one get MS if the outflow is impaired?

Hmmmmmmm....

http://www3.interscience.wiley.com/journal/119147945/abstract?CRETRY=1&SRETRY=0

_________________
Three veins angioplastied.  One renewed life.  

BooBear
I'd like to read the article, but can't get access to Wiley.
Is it too long to post?
If so, how do you get to read it thru Wiley?
Thanks

Shye, I will try to post the entire article today.

_________________
Three veins angioplastied.  One renewed life.  

Nevermind- it is in PDF format.

Try this link:
http://www3.interscience.wiley.com/cgi- ... 5/PDFSTART

_________________
Three veins angioplastied.  One renewed life.  

Thanks BooBear
Not easy reading--but appears that the influx of blood and iron is pretty well know, but not the efflux:
"As there is apparently a constant influx of iron into the adult brain, it is pertinent to enquire as to how the iron leaves the brain. A probable route is via the bulk drainage of CSF..."
So much is still unknown about the very things that are causing problems in MS.

What I found really scary in this article was:
"there is evidence that neuroleptic drugs, such as chlopromazine and haloperidol, may increase entry of iron in brain across the BBB (...1994), thus perhaps inducing extrapyramidal side effect, eg, tardive dyskinesia."
Of course, these drugs are still being used!


so, all these effects could be iron overload, caused by the medicine?????
Similar, I think, to a lot of MSers symptoms.
Medicines are dangerous--the full effects are never known.

Shye, that quote got me, too.

I chose, of my own volition, to stop taking the CRABS five weeks ago. I feel better, frankly.

I am done with all the drugs for now. I want to get Liberated (just six more weeks to go!), see how I do, then make the right diet and medicinal (if necessary) choices afterwards.

As you note, there is still so much we don't know. But I find the comments on efflux in a paper from 2002 interesting now in light of CCSVI.

_________________
Three veins angioplastied.  One renewed life.  

BooBear-
Good luck in 6 weeks

hi boobear
thanks for that paper and your discovery re efluxing and drugs that drop more iron in the brain. i take no drugs, but was pondering LDN , i may just wait for my 2nd trip to poland sometime in august to hopefully get a stent, which i think at this point i'd rather have, hmmmm