Interesting paper on brain iron- 2002

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Interesting paper on brain iron- 2002

Postby BooBear » Tue Jun 29, 2010 9:33 am

Interesting paper that discusses transport of iron in the brain-blood barrier-CSF.

The last quote on the main page is what makes CCSVI very real:

A system in which influx of iron into brain is by regulated receptor-mediated transport and in which efflux is by bulk flow is ideal for homeostasis of brain iron.


In short, the intake of iron into the brain is regulated and the efflux is by open flow. That makes for ideal conditions according to the authors.

So what happens if one or the other- or both?- are off?

If the receptors misfire, one could get too much iron intake (Parkinsons? Alzheimers?). Does one get MS if the outflow is impaired?

Hmmmmmmm....

http://www3.interscience.wiley.com/journal/119147945/abstract?CRETRY=1&SRETRY=0
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Postby shye » Wed Jun 30, 2010 10:50 am

BooBear
I'd like to read the article, but can't get access to Wiley.
Is it too long to post?
If so, how do you get to read it thru Wiley?
Thanks
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Postby BooBear » Thu Jul 01, 2010 5:32 am

Shye, I will try to post the entire article today.
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Postby BooBear » Thu Jul 01, 2010 5:34 am

Nevermind- it is in PDF format.

Try this link:
http://www3.interscience.wiley.com/cgi- ... 5/PDFSTART
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Postby shye » Thu Jul 01, 2010 12:16 pm

Thanks BooBear
Not easy reading--but appears that the influx of blood and iron is pretty well know, but not the efflux:
"As there is apparently a constant influx of iron into the adult brain, it is pertinent to enquire as to how the iron leaves the brain. A probable route is via the bulk drainage of CSF..."
So much is still unknown about the very things that are causing problems in MS.

What I found really scary in this article was:
"there is evidence that neuroleptic drugs, such as chlopromazine and haloperidol, may increase entry of iron in brain across the BBB (...1994), thus perhaps inducing extrapyramidal side effect, eg, tardive dyskinesia."
Of course, these drugs are still being used!

SIDE EFFECTS: The most common side effects associated with haloperidol are extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes), dizziness, hyperactivity, tiredness, and nausea. Haloperidol may cause a condition called "orthostatic hypotension" during the early phase of treatment (first week or two). Orthostatic hypotension causes patients to become dizzy upon arising from a lying or sitting position because of a fall in blood pressure.

so, all these effects could be iron overload, caused by the medicine?????
Similar, I think, to a lot of MSers symptoms.
Medicines are dangerous--the full effects are never known.
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Postby BooBear » Fri Jul 02, 2010 4:04 am

Shye, that quote got me, too.

I chose, of my own volition, to stop taking the CRABS five weeks ago. I feel better, frankly.

I am done with all the drugs for now. I want to get Liberated (just six more weeks to go!), see how I do, then make the right diet and medicinal (if necessary) choices afterwards.

As you note, there is still so much we don't know. But I find the comments on efflux in a paper from 2002 interesting now in light of CCSVI.
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Postby shye » Fri Jul 02, 2010 6:04 am

BooBear-
Good luck in 6 weeks :!:
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Postby esta » Fri Jul 02, 2010 8:41 am

hi boobear
thanks for that paper and your discovery re efluxing and drugs that drop more iron in the brain. i take no drugs, but was pondering LDN , i may just wait for my 2nd trip to poland sometime in august to hopefully get a stent, which i think at this point i'd rather have, hmmmm
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