Not easy reading--but appears that the influx of blood and iron is pretty well know, but not the efflux:
"As there is apparently a constant influx of iron into the adult brain, it is pertinent to enquire as to how the iron leaves the brain. A probable
route is via the bulk drainage of CSF..."
So much is still unknown about the very things that are causing problems in MS.
What I found really
scary in this article was:
"there is evidence that neuroleptic drugs, such as chlopromazine and haloperidol, may increase entry of iron in brain across the BBB (...1994), thus perhaps inducing extrapyramidal side effect, eg, tardive dyskinesia."
Of course, these drugs are still being used!
SIDE EFFECTS: The most common side effects associated with haloperidol are extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes), dizziness, hyperactivity, tiredness, and nausea. Haloperidol may cause a condition called "orthostatic hypotension" during the early phase of treatment (first week or two). Orthostatic hypotension causes patients to become dizzy upon arising from a lying or sitting position because of a fall in blood pressure.
so, all these effects could be iron overload, caused by the medicine?????
Similar, I think, to a lot of MSers symptoms.
Medicines are dangerous--the full effects are never known.