The only folks that should be giving up hope at this point is the neurologist, not the patients.
The fact remains - neurologists are about as effective in treating MS as I am at flying under my own power. Neurologist do not know what causes the disease, they dont even know why or how the drugs they prescribe work. In fact, all drug companies start with the statement 'It is believed that the mode of action is....". A 32% efficacy rate in MS drugs across the board is more like a placebo when the multiple institutions have found ~90% of all MS patients have venous malformations. The other ~10% more than likely have intermittent venous malformations based on mechanical obtrusion (vertebrae, etc) or postural issues not evident when in position for a scan.