Link is still broken! I tried.
Would the inflammatory cascades and free radicals scavenging happens in the same way in CCSVI? This is inflammation within the veins.
One of the differences between CVI and CCSVI (besides proximity to delicate brain and spine tissue!) is the effects of gravity on a condition at the bottom of the body, where blood needs to be pumped up a good distance, and at the top of the body, where gravity is working with us. (We would all be in even worse shape if our brains were in our feet.
) Not sure how this affects any comparisons.
This article also talked about in CVI how one blockage causes blocked up blood which causes a further-up valve to blowout...I raised this question in DrS's thread and he did not think much of this was going on in CCSVI, that the valve issues in question are predominantly valvular malformations not secondary blowouts.
The main thing I took away from this article is that making a mouse model is easy enough for CVI. They can occlude the veins or ligate them or whatever the third way was. I don't see doing this in a brain-draining vein as being that different. The difficulty would be in creating the right degree of occlusion, so that a longer-term effect can be seen; MS takes on average 30 years to show up. The other concern might be the structure of the neck and if that affects brain drainage in a mouse as compared to a human. I will look and see if there are mouse models for cerebral thrombosis or that sort of thing can tell us anything.