MarkW wrote:This study is on mouse arteries not veins, which are physically and physiologically completely different. Please be careful before you apply these results to CCSVI.
I actually spoke with a couple of vascular doctors before publishing that note. The endothelial lining of blood vessels is the same in arteries and veins, and disturbed blood flow does indeed create changes to the lining of the vessel and increase localized inflammation.
The affect in arteries is different (in relation to plasmic deposition of fats/clots) but disturbed blood flow will change a venous wall as well, and increase a stenotic environment, even creating thrombi. The docs believe this is why CCSVI progresses over the years. The vascular malformations grow as the body grows, and the disturbed blood flow creates a cycle of inflammation and endothelial disfunction. I'm very careful to check my writing out with the doctors before putting on the Facebook page.