Myelin lipids and CCSVI

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Myelin lipids and CCSVI

Postby monik_77 » Fri Jul 09, 2010 3:20 pm

According to Buffalo study, based on the reporting of 38% for CIS vs about 80% for MS with more advanced symptoms, for me meaning that the prevalence of CCSVI increase with the time course of the disease.
We know that the composition of the myelin is 80% lipids. I was thinking that could be that the stenosis of the venus could be due to the accumulation of lipids that come from the myelin, when it is destroyed for the immune system and for that the vascular problem is a consecuence of the disease. Also this consecuence will make additional symptoms that can be solved with the liberation treatment.
What do you think??

Cheers,

Moni.
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Postby Cece » Fri Jul 09, 2010 5:09 pm

Stranger things have happened...but I don't think these stenoses are too similar to the stenoses in arteries, where they are built-up plaques from fat. These are more like thickened valves, backwards valves, missing jugulars...it is hard for me to see how lipid build-up could cause those things but I also don't have a great explanation for the worsening of CCSVI as the disease progresses as suggested by the Buffalo study.
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Postby TMrox » Sat Jul 10, 2010 2:48 am

Is this 38% incidence of CCSVI referred exclusively to CIS?

My understanding is that the 38% refers to 'other neuro conditions apart from MS' That consists of 21 people with clinically isolated syndrome (CIS) and 24 people with “other neurologic disease” (neurosarcoidosis, epilepsy, hashimoto's disorder, among others).

I've asked Buffallo (twice) which were the 'other neurological conditons' included in their study and whether my conditon (Transverse Melitis) was explored. I was told to wait until the full results are published in a journal.

Well I have Transverse Myelitis and CCSVI. A neuro (not involved in my case) but who is openly against CCSVI thinks that I might have been born with CCSVI, and that TM contributed further to the inflammation of my veins which worsen my stensoses. This doc doesn't think that the worsening of my veins occurred as in artheresclorosis, but probably by a different process, which he did not explain.

In the point of view of this doc we do not know enough about whether CCSVI leads to neuro conditions or whether the neuro conditon worsens CCSVI. So both of us are waiting to hear from ongoing clinical trials, some of them which seems to be including a sub-group of TM patients.
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Postby monik_77 » Sat Jul 10, 2010 4:09 am

Yes 38% is only for CIS.

But if we consider that since only about half of those diagnosed as CIS go on to full blown MS, for that 38% is closer to 80% or not???
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Postby Sotiris » Sat Jul 10, 2010 11:35 am

Cece wrote:[...]I also don't have a great explanation for the worsening of CCSVI as the disease progresses as suggested by the Buffalo study.
Actually, the given percentages correspend to the probability of finding CCSVI. This does not necessarily mean that CCSVI worsens with MS progression. It can simply mean that if your CCSVI is bad you have a bigger probability of MS progression.
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Postby TMrox » Sat Jul 10, 2010 11:55 am

Up to 80% of CIS people are confirmed with MS
http://archneur.ama-assn.org/cgi/conten ... t/63/4/614

The fact that Buffalo did not find an extremelly high incidence of CCSVI among CIS people would suggest:

1) MS=CCSVI+something else or

2) The study of CCSVI among other neuro conditons needs to be replicated (using Zamboni's criteria, venography) and a larger sample. The buffalo study unfortunately only included 21 CIS people, no much statistical power there. Also oddly enough Buffalo's incidence of CCSVI in MS differs to that of other studies.
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