Donnchadh wrote:Even if the liberation procedure was a 100% success and the veins were fully re-opened, there's still question of how to get rid of the iron that has already been accumulated. I have been progressive for twenty years, so there must be quite a lot deposited by now.
ms2009 wrote:Good luck with your chelating and your second liberation. If the blood went back to regular flow, it will be able to get rid of some or most of the accumulated iron in the tissues. If not, chelating might help but be careful in case you have amalgam in your teeth.
sbr487 wrote:Donnchadh wrote:Even if the liberation procedure was a 100% success and the veins were fully re-opened, there's still question of how to get rid of the iron that has already been accumulated. I have been progressive for twenty years, so there must be quite a lot deposited by now.
Donnchadh, I have a completely different take and I could be totally wrong ...
Don't underestimate our body's ability to heal itself. Most of us have sustained MS onslaught for years yet we continue to function (although less effectively). So when the underlying factor is removed the gains should be very good except for those parts that have undergone permanent damage. But unlike other organs there is a high level redundancy in brain.
On the assumption that iron has been depositing for years - please remember that if CCSVI were to be true, MS itself is due to frequent iron cleansing that has been taking place.
Let me also say this there have been some days when I have felt almost symptom free (clear head, able to function very efficiently ...). That tells me that our body has retained most of its abilities even when are afflicted with MS.
Free Radic Biol Med. 2010 Aug 1;49(3):401-407. Epub 2010 May 5.
Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload.Gao X, Qian M, Campian JL, Marshall J, Zhou Z, Roberts AM, Kang YJ, Prabhu SD, Sun XF, Eaton JW.
Department of Oncology, University of Linköping, Linköping, Sweden; Molecular Targets Group, J. G. Brown Cancer Center, Louisville, KY 40202 USA.
In patients with hemochromatosis, cardiac dysfunction may appear years after they have reached a state of iron overload. We hypothesized that cumulative iron-catalyzed oxidant damage to mitochondrial DNA (mtDNA) might explain the cardiomyopathy of chronic iron overload. Mice were given repetitive injections of iron dextran for a total of 4weeks after which the iron-loaded mice had elevated cardiac iron, modest cardiac hypertrophy, and cardiac dysfunction. qPCR amplification of near-full-length ( approximately 16kb) mtDNA revealed >50% loss of full-length product, whereas amounts of a qPCR product of a nuclear gene (13kb region of beta globin) were unaffected. Quantitative rtPCR analyses revealed 60-70% loss of mRNA for proteins encoded by mtDNA with no change in mRNA abundance for nuclear-encoded respiratory subunits. These changes coincided with proportionate reductions in complex I and IV activities and decreased respiration of isolated cardiac mitochondria. We conclude that chronic iron overload leads to cumulative iron-mediated damage to mtDNA and impaired synthesis of mitochondrial respiratory chain subunits. The resulting respiratory dysfunction may explain the slow development of cardiomyopathy in chronic iron overload and similar accumulation of damage to mtDNA may also explain the mitochondrial dysfunction observed in slowly progressing diseases such as neurodegenerative disorders. Copyright © 2010 Elsevier Inc. All rights reserved.
PMID: 20450972 [PubMed - as supplied by publisher]
Donnchadh wrote:I then thought about something: Why is it that while I had the identical venous problems 10 years ago, I could more or less walk normally then and I can't now? I had the exact same stenosis in the exact same location. What is different?
JoyIsMyStrength wrote:Donnchadh wrote:I then thought about something: Why is it that while I had the identical venous problems 10 years ago, I could more or less walk normally then and I can't now? I had the exact same stenosis in the exact same location. What is different?
Donnchadh, out of curiosity, how do you know for sure what your venous probs were 10 years ago? (Not being contentious, just sincerely interested.) For me, they found "congenitally hypoplastic" (underdeveloped) left jugular so that would mean from birth but I have no way of knowing how long all the collaterals have been there.
As for donating blood, I was told I couldn't donate because of the MS. Also I am slightly anemic. It's confusing. Low iron makes one anemic = fatigue. Too much iron = same.
This kind of makes me wonder if donating blood is *sort of* like plasmapherisis. The blood isn't filtered but perhaps it gets replaced (regenerated) with newer, fresher blood? Is that plausible?
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