Another area I've been interested in documenting, and doctors are testing for this using fMRI BOLD technology pre and post angioplasty, is that CCSVI creates diffuse cerebral hypoxia in MS brains. Being at high altitude creates a more severe hypoxic situation, increasing cellular death and activating the immune system.
CONCLUSION: These findings suggest that extremely high-altitude exposures may cause subtle white and grey matter changes that mainly affect brain regions involved in motor activity.
However, there is impairment of central nervous system function at high altitude which persists following return to sea level.
Significant abnormalities of motor coordination persisted for more than 12 months in most members of the Everest expedition.
There is evidence that the climbers who ventilate most at high altitude have the most central nervous system impairment, presumably because of the more severe cerebral vasoconstriction
Shayk wrote:Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areasCONCLUSION: These findings suggest that extremely high-altitude exposures may cause subtle white and grey matter changes that mainly affect brain regions involved in motor activity.
...."clear improvement after angioplasty"
The other focus is epidemiology, the effects of hypoxia on lifespan and progression of cancer, heart disease, obesity, lung diseases, and neurological diseases, including Alzheimer’s and multiple sclerosis. Projected studies will investigate multiple sclerosis progression, longevity, cardiovascular disease, and behavior of malaria at altitude. Medical applications for these studies are being realized in conjunction with sophisticated geographic information systems technology that tracks migrations of populations.
Research director Robert Roach, Ph.D., is investigating the brain response to hypoxia and its relation to AMS and the genetics of AMS and human athletic performance. Vaughn Browne, M.D., Ph.D., studies the genetics of low birth-weight babies at altitude, investigating the differences in pregnancy adaptations of women whose ancestors lived in the Bolivian Andes for millennia compared to European women whose ancestors lived at altitude for only a few generations.
ARC scientists are offering their expertise to high-altitude clinical research projects worldwide. Ultimately, experts hope understanding gained through research improves the clinical treatment of problems related to hypoxia.
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