Gut Bacteria in Relation to MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Gut Bacteria in Relation to MS

Postby daniel » Tue Jul 20, 2010 12:03 pm

Hey All,

Thought others may find this interesting as well so I'm forwarding it along. As it's seeming like ccsvi is not the only potential cause of MS, this may be another clue

....
When Hood's animals were housed at Caltech, they developed the disease. But, oddly, when the mice were shipped to a cleaner biotech facility -- where their resident gut bacterial populations were reduced -- they didn't get sick.
...snip...
To find out, Mazmanian and his colleagues tried to induce MS in animals that were completely devoid of the microbes that normally inhabit the digestive system. "Lo and behold, these sterile animals did not get sick," he says.
Then the researchers decided to see what would happen if bacteria were reintroduced to the germ-free mice. But not just any bacteria. They inoculated mice with one specific organism, an unculturable bug from a group known as segmented filamentous bacteria. In prior studies, these bacteria had been shown to lead to intestinal inflammation and, more intriguingly, to induce in the gut the appearance of a particular immune-system cell known as Th17. Th17 cells are a type of T helper cell -- cells that help activate and direct other immune system cells. Furthermore, Th17 cells induce the inflammatory cascade that leads to multiple sclerosis in animals
...

http://www.sciencedaily.com/releases/20 ... 162643.htm
User avatar
daniel
Family Elder
 
Posts: 203
Joined: Tue May 19, 2009 3:00 pm
Location: Toronto, Canada

Advertisement

Postby bestadmom » Tue Jul 20, 2010 6:27 pm

This article is about EAE, not MS. EAE is a manufactured autoimmune condition in mice. It isn't MS. People do not get EAE and mice do not get MS when induced in this way.
User avatar
bestadmom
Family Elder
 
Posts: 722
Joined: Mon May 18, 2009 3:00 pm
Location: CT

Postby fogdweller » Tue Jul 20, 2010 10:08 pm

bestadmom wrote:This article is about EAE, not MS. EAE is a manufactured autoimmune condition in mice. It isn't MS. People do not get EAE and mice do not get MS when induced in this way.


amen! We decided MS was probably autoimmune, we induced an autoimmune disease in mice that generated MS-like symptoms (in mice) and then use that to argue that MS must be an autoimmune disease. About as circular as you can get.

very few of treatments that show promise because they help EAE mice do anything at all for human MS. You would think someone would have gotten the message by now that EAE is not a good model for MS (perhaps because MS is not caused by autoimmunity?!!)
User avatar
fogdweller
Family Elder
 
Posts: 412
Joined: Tue Dec 08, 2009 4:00 pm

Postby Algis » Tue Jul 20, 2010 10:12 pm

When I was diagnosed 12 years ago; the neurologist already told me that EAE is a bad model for MS. He also said that auto-immune was an assumption rather than deduction in MS.
User avatar
Algis
Family Elder
 
Posts: 783
Joined: Sat Nov 21, 2009 4:00 pm
Location: XinDian, Taiwan

Postby bestadmom » Tue Jul 20, 2010 10:41 pm

Algis, your Neuro is a keeper. We need more open minded ones to question the status quo. P
User avatar
bestadmom
Family Elder
 
Posts: 722
Joined: Mon May 18, 2009 3:00 pm
Location: CT


Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users