The correlation of MS with anxiety symptoms
and disorders in general 3-5 and with generalized
anxiety disorder, panic attacks 6 and OCD 7,
specifically, has been well documented.
Anxiety disorders in multiple sclerosis: significance of obsessive-compulsive
Amir Shabani*, Jafar Attari Moghadam*, Leily Panaghi**, Arshia Seddigh***
BACKGROUND: Considering reports on the associations of symptoms of anxiety disorders with multiple sclerosis (MS),
this study aimed to 1) further evaluate various anxiety disorders systematically presenting in patients with MS and 2)
compare the results with a control group.
METHODS: To assess anxiety disorders in patients with MS in a case-control study, 85 registered patients in the Iranian
Multiple Sclerosis Society (IMSS) were randomly selected according to the inclusion criteria. A group of healthy individuals
whose age and gender were matched with the case group were also selected. Both groups underwent a clinical
interview based on DSM-IV diagnostic criteria.
RESULTS: Frequency of diagnosis of all anxiety disorders in the two groups was 22.4% and 7.1%, respectively, indicating
a statistically significant difference. Frequency of obsessive-compulsive disorder (OCD) was significantly higher in
the case group (P<0.05). Relation of university education with the diagnosis of generalized anxiety disorder was significant
CONCLUSIONS: OCD in patients with MS was more frequently observed than in the control group.
KEY WORDS: Multiple sclerosis, obsessive-compulsive disorder, anxiety, neuropsychiatry.