So glad you asked me that question Johnson, as I've looked into it a bit more and found this research.
T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions.
Hönscheid A, Rink L, Haase H.
Institute of Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
The trace element zinc is a crucial cofactor for many proteins involved in cellular processes like differentiation, proliferation and apoptosis. Zinc homeostasis is tightly regulated and disturbance of this homeostasis due to genetic defects, zinc deficiency, or supplementation influences the development and the progression of various infectious and autoimmune diseases. The immune system is strongly impaired during zinc deficiency, predominantly the cell-mediated response by T-lymphocytes. During zinc deprivation T-lymphocyte development, polarization into effector cells, and function are impaired. This leads to reduced T-cell numbers, a decreased ratio of type 1 to type 2 T-helper cells with reduced production of T-helper type 1 cytokines like interferon-gamma, and compromised T-cell mediated immune defense. Accordingly, disturbed zinc homeostasis increases the risk for infections, and zinc supplementation restores normal immune function. Furthermore, several disorders, like mycobacterial infections, asthma, diabetes, and rheumatoid arthritis are accompanied by decreased zinc levels and in some cases disease progression can be affected by zinc supplementation. On the molecular level, apoptosis of T-cell precursors is influenced by zinc via the Bcl-2/Bax ratio, and zinc ions inhibit caspases-3, -6, -7, and -8. In mature T-cells, zinc interacts with kinases involved in T-cell activation, like protein kinase C and the lymphocyte protein tyrosine kinase (Lck), while higher zinc concentrations are inhibitory, reducing the activities of the interleukin-1 receptor-associated kinase (IRAK) and calcineurin. Taken together, zinc homeostasis influences T-lymphocytes via several molecular targets, leading to a modulation of T-cell-dependent immune responses.
So that is probably my answer to why zinc affects me badly.
I have Lymphocytosis due to a splenectomy at 13yrs.
They removed my spleen which had ruptured in an accident.
Looking back over my blood tests this year, since taking the zinc, my T-lymphocyte count rose dramatically, and I developed luekisitosis also (high RBC) amongst other things, culminating in the lymphocytes collecting in my skin in October and it erupted as a blister rash.
I need something to calm down my immune system, and I think zinc may rev it up
I'd say this is quite unique to me, so don't let it put you off zinc.