L wrote:elliberato wrote:1eye wrote:Or that mono makes it easier for areas with malformations to have inflammation?
I seem to remember a Zivadinov effort that concluded there are mostly antibodies to dormant mono, not to a current or re-infection. How those antibodies interacted with 'MS', I do not remember.
I may have this backwards but I believe mono is a byproduct of the Epstein Barr Virus. As well the Virus can stay in the system with the Mono turning on or off...Either way I had it around 16 yrs as well and Ms at 40. Here we go with the chicken and the egg thing. If Zamboni turns out to be correct with the theory of CCSVI in vetro and malformations at birth, unfortunately it doesnt explain the effect of Epstein Barr...
Yes it does. It also may explain why high dose cyclophosphamide and rituximab work with MS. They both destroys B cells where the dormant EBV hides. No B cells, no EBV. I have never read anything about people with whom HDC failed and whether or not they get reinfected. I'd be very interested to find out.
J Neurol Neurosurg Psychiatry wrote:Possible connection to Chronic Cerebrospinal Venous Insufficiency - CCSVI explained.
Re: Epstein–Barr virus is associated with grey matter atrophy in multiple sclerosis
R Zivadinov, M Zorzon, B Weinstock-Guttman, M Serafin, A Bosco, A Bratina, C Maggiore, A Grop, M A Tommasi, B Srinivasaraghavan, M Ramanathan
J Neurol Neurosurg Psychiatry 2009;80:620-625 Published Online First: 23 January 2009 doi:10.1136/jnnp.2008.154906
I read the article by Zivadinov (1) with reference to the association of Epstein-Barr virus (EBV) to gray matter atrophy in multiple sclerosis (MS) patients.
Accumulation of EBV infected B cells in meninges and perivascular regions of MS lesions in 21 or 22 patients with MS (2) was noted as well, indicating direct involvement of the brain and perivascular spaces by EBV in MS patients..
A recent study has indicated chronic cerebrospinal venous insufficiency with multiple extracranial venous strictures in MS patients (3).
EBV appears to infect endothelial cells (4), and may be important in the pathology of EBV virus.
EBV virus has been found to cause deep venous thrombosis in a patient with hereditary thrombophilia (5).
EBV may infect the venous endothelium causing venous thromboses and strictures in the cranial and spinal venous drainage system and perivascular regions of MS lesions in patients with MS.
Such venous involvement may be implicated in MS disease involvement.
Chronic EBV infection may involve the venous system with secondary effects on the brain and spinal cord in MS.
1.Zivadinov R, Zorzon M, Weinstock-Guttman B, Serafin M, Bosco A, Bratina A, et al.
Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis
J Neurol Neurosurg Psychiatry 2009; 80: 620 -625.
2.Serafani B, Rosicarelli B, Franciotta D, et al.
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain.
J Exp Med 2007; 204:2899-2912.
3. Zamboni P, Galeotti P, Menegatti E, Malagoni AM, Tacconi G, et al.
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis.
J Neurol Neurosurg Psychiatry 2009: 80: 392-398.
4. Jones K, Rivera C, Sgadari C, Franklin J, Max EE, et al.
Infection of human endothelial cells with Epstein-Barr virus.
J Exp Med. 1995; 182: 1213-1221.
5. Mashav N, Saar N, Chundadze T, Steinvil.
Epstein-Barr virus associated thromboembolism: A case report and review of the literature.
Thromb Res. 2008; 122: 570-571.
No conflict of interest.
Steven R Brenner, Neurologist
St. Louis VA Medical Center and Dept Neurology and Psychiatry at St. Louis University
Source: J Neurol Neurosurg Psychiatry © 2009 by the BMJ Publishing Group Ltd
The pathology this seems to be describing is EBV -> MS, and also EBV ->CCSVI. I think that that is what I originally thought might happen, and it yet might prove to be, but I have seen some fairly convincing arguments that VMs are congenital, in this as well as other conditions. The argument that both cause aspects of MS, is appealing to me.