Nunzio wrote:KDGO wrote:What should an IR do if there is no symptom of clotting, pain, swelling etc however the MRV picture presents M-T? Do they angio & conctrast nyway to make sure all is ok or just leave it alone?
The idea is that if you have M-T then the return blood from the leg, instead of draining in the IVC it goes through collaterals to the Azygous vein and overload it so it cannot drain blood from the spinal cord properly.
So, if you have MS have M-T fixed, and have them check the renal vein too.
The liver is known to have a very high capacity for regeneration. In fact, mammals (including humans) can survive surgical removal of up to 75% of the total liver mass. The original number of cells is restored within 1 week and the original tissue mass within 2 to 3 weeks.
HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein ... that is critical for liver development
...HNF41 positively regulates genes involved in the transport of lipids and vitamins as well as genes involved in lipid, amino acid, and glucose metabolism. It also regulates genes involved in the regulation of several serum proteins such as blood coagulation factors, erythropoietin, and antithrombin III.
Zinc-enhanced liver regeneration was associated with an increase in hepatocyte nuclear factor-4 (HNF-4), a liver-enriched, zinc-finger transcription factor.
Summary: Antithrombin 3 deficiency... an autosomal dominant disorder causing hypercoagulability and recurrent thrombosis.
. or, the liver.Notable examples that have been suggested but that require further research include involvement in the regulation of cellular growth and differentiation, including gene expression, and in the regulation of apoptosis(Zalewski et al. 1994 ).
The other is the central but still incompletely understood role, or complex combination of roles, that zinc has in gene expression and in cellular growth and differentiation.
Even a partial understanding ... alerts us to the special vulnerability to an inadequate supply of zinc of the rapidly growing embryo, fetus, infant and young child or of the patient mounting an immune response or requiring tissue repair. ...the extraordinary rapidity ... effects of dietary zinc restriction on growth and differentiation ... correctly alerts us to the special vulnerability to zinc deficiency of cells that are rapidly turning over, notably those of the immune system...
Other zinc atoms have specific structural roles in enzyme molecules as well as in many other proteins and in biomembranes. ... One outstanding example that has generated a great deal of recent interest is the zinc finger motif (Berg and Shi 1996 , Rhodes and Klug 1993 ), the most common recurring motif in transcription proteins. The configuration of these "fingers," which determines their binding to DNA, is determined by the single zinc atom at their base. The linking of these zinc fingers to corresponding sites on DNA initiates the transcription process and gene expression.
jimmylegs wrote:adam, yeeks!! do you do bloodwork so that you know where your copper/zinc ratio is at?
i would not say right off to add zinc. might want to back off on the copper. hard to say without a lab result or two.
selkie wrote:Adam you may also want to check w/Dr. S on this or a vascular doctor. If you azygos is truly fine (and depending on your age), I'd think they wouldn't want to do anything invasive, just a guess. Maybe there's non-invasive ways like the supplements jimmylegs suggested. But for your own peace of mind, you may want to check w/a dr too
oh right i didnt realise the ratio had to be precise,
but for the last 3 years i have been taking etween 50-100mg of zinc, and 2-8mg of copper,
aslong as im taking both zinc and copper, does the ratio matter so much ?
adamt wrote:oh dear, i guess i should get the MT ballooned/stented A,s,a,p then
or do you think i sould hold out for a few weeks to watch for changes/improvements first?
Cece - you said:
May Thurners blockage is instead rerouted to the azygous which in ccsvi does not have the capacity to carry its own load, let alone the iliac vein's load too, and over time you get the spinal cord damage.
As my Azygos was fine/normal and had No CCSVI, would this mean i wont get the spinal cord damage?
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