Research Paper MS as a Vascular Disease

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Research Paper MS as a Vascular Disease

Postby orion98665 » Sat Aug 21, 2010 8:52 pm

Just another interesting article written as a neurological research paper back
in 2006.

<shortened url>
Last edited by orion98665 on Sat Aug 21, 2010 9:04 pm, edited 1 time in total.
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Postby MrSuccess » Sat Aug 21, 2010 9:02 pm

published April 2006 ........ that's interesting

A vascular connection in early MS ......

Has this research team contacted Dr. Zamboni ?




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Postby orion98665 » Sat Aug 21, 2010 9:14 pm

Just purchased article. Very interesting. Well worth the $48.00.
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Postby orion98665 » Sat Aug 21, 2010 9:17 pm

MrSuccess wrote:published April 2006 ........ that's interesting

A vascular connection in early MS ......

Has this research team contacted Dr. Zamboni ?




Mr. Success



I don't know. I've just discovered this paper, purchased it and I'm now reading it.
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Postby Ruthless67 » Sat Aug 21, 2010 10:35 pm

orion98665,

Great find!! Hope you'll share some of what you glean from the article.

When I read where folks are asking what they should take to their Neurologist, or MD, I think articles that are written by Neurologists that virtually describe CCSVI should definitely be "in the packet".

Lora
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Postby orion98665 » Sat Aug 21, 2010 10:42 pm

Sh*t, don't purchase this paper I've just discovered it for FREE. :roll:


http://www.shreveportphysiology.com/Ale ... MS.pdf.pdf
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Postby sbr487 » Sat Aug 21, 2010 11:57 pm

ccsvi alliance is collating all research materials ... you can contact alliance team ...
A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it
- Max Planck
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Postby Cece » Sun Aug 22, 2010 12:08 am

Great paper! I don't remember seeing this one before. And the references hint at even more leads:
1 Grieb P, Forster RE, Strome D, et al. O2 exchange between blood
and brain tissues studied with 18O2 indicator-dilution technique.
J Appl Physiol 1985; 58: 1929–1941
2 Hirase T, Staddon JM, Saitou M, et al. Occludin as a possible
determinant of tight junction permeability in endothelial cells.
J Cell Sci 1997; 110: 1603–1613
11 Kirk J, Plumb J, Mirakhur M, et al. Tight junctional abnormality in
multiple sclerosis white matter affects all calibres of vessel and is
associated with blood–brain barrier leakage and active demyelination.
J Pathol 2003; 201: 319–327
25 Kraus J, Ling AK, Hamm S, et al. Interferon-b stabilizes barrier
characteristics of brain endothelial cells in vitro. Ann Neurol 2004;
56: 192–205

It would be nice to understand some of this.
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Postby selkie » Sun Aug 22, 2010 1:36 am

Thanks, Orion - just downloaded it & will read it later. Great that it's by neuros - think I'll get a packet to mail to mine.
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Postby orion98665 » Sun Aug 22, 2010 2:32 am

Cece wrote:Great paper! I don't remember seeing this one before. And the references hint at even more leads:
1 Grieb P, Forster RE, Strome D, et al. O2 exchange between blood
and brain tissues studied with 18O2 indicator-dilution technique.
J Appl Physiol 1985; 58: 1929–1941
2 Hirase T, Staddon JM, Saitou M, et al. Occludin as a possible
determinant of tight junction permeability in endothelial cells.
J Cell Sci 1997; 110: 1603–1613
11 Kirk J, Plumb J, Mirakhur M, et al. Tight junctional abnormality in
multiple sclerosis white matter affects all calibres of vessel and is
associated with blood–brain barrier leakage and active demyelination.
J Pathol 2003; 201: 319–327
25 Kraus J, Ling AK, Hamm S, et al. Interferon-b stabilizes barrier
characteristics of brain endothelial cells in vitro. Ann Neurol 2004;
56: 192–205

It would be nice to understand some of this.


Cece, after reading this research paper i find it way too complex to fully understand. Maybe somebody on this forum with a little more knowledge can decipher this. lol
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Postby Blaze » Sun Aug 22, 2010 6:28 am

Thanks! This one is definitely going to my family physician and my neurologist!
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Postby rssugg » Sun Aug 22, 2010 7:29 am

ditto! great find
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Postby Daisy3 » Sun Aug 22, 2010 7:31 am

Concluding remarks from this paper:

In conclusion, MS definitely shows many of the
characteristics associated with vascular inflammatory
phenomena, underscoring significant roles of the
cerebral vascular system, cerebral vascular inflammation
and defects with the blood–brain barrier in active
MS. The well documented immune components of MS
must interact with the vascular system in introducing
and maintaining the cells which drive the inflammatory
response and involve the expression of adhesive
determinants (under the control of unbalanced cytokines),
their penetration and destruction of the BBB and
the development of the MS lesion, all of which may be
future targets with immunomodulating drugs and
regulatory cytokines.


I didn't get much of the paper-too much jargon that I am unfamiliar with despite my sort of background in the medical field! I did get the above though...these guys are actually saying that the vascular system matters!
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Postby cheerleader » Sun Aug 22, 2010 9:31 am

Yes---the Alliance has links to this paper and the newest one (2010) from this research team, thanks to Shayk of TIMS.

Here's the new abstract on cerebral endothelial dysfunction, hot off the presses
http://www.ncbi.nlm.nih.gov/pubmed/20663648
(those who've been on this site will know the endothelium is what brought me to the vascular research in MS. It's gratifying to see more research looking at the connection)

For the complete paper of '06, go to www.ccsvi.org
under "advanced topics" we have many of the research papers linked in toto-

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby selkie » Sun Aug 22, 2010 11:12 am

Whenever I don't understand a too technical paper, I skip right to the conclusion like Daisy did.

The other thing you can do is wait until Dr. Sclafani gets back, post the link in his thread, and ask *specific* questions you may have.

Overall, I would say from reading the conclusion that this study - done by neurologists - certainly confirms Dr. Zamboni's theory that the vascular system plays a role in the development of MS.

It makes me so angry I could spit, that my neurologist said of Dr. Z's theories (w/out even reading his paper that was published in at least two medical journals) and of CCSVI, "that nothing much will come of it" - simply parroting another neuro he knows who made that comment.

This kind of blindness in the medical field is why we're all having to become vascular "experts" (ha) ourselves and spend our own money to be treated for a very real medical condition, a vascular deformity that our insurance companies should be paying for.

But calling attention to papers like this, will hopefully get more of the medical community to wake tf up.
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