1. 100%, 100%, 100%
2.no blind study to test against placebo effect
Dr. Sclafani has addressed this in his thread. He believes that it is unethical to sedate people to the extent that would be necessary such that they could not tell whether or not they were actually treated. Many people treated for CCSVI have reported that it was obvious when the balloon was being inflated. Sedation would expose people to unnecessary risk. Moreover, simply inserting a catheter into the jugular or azygous vein may clear out some obstruction. There are many types of blockages including a septum, a thin membrane blocking the vein, which could be cleared via a catheter insertion. Moreover, Zamboni's paper states that the doctors evaluating the patients were blinded to an individuals MS status.
3.participants in his study continued to take MS therapy drugs
Pharmaceutical companies do this all the time. Remember Avonex + Tysabri? Copaxone with Revimmune? Copaxone with Novantrone? Anyways, MS/CCSVI may be a disease of chronic immune activation and continuation of DMDs may be prudent to help correct the chronically activated immune system.
4. he went straight to the social media which bypassed any critical review of his research by his peers
False. Zamboni published in peer reviewed science journals well before the rest of us found out about it.
5.to perform the "liberation" procedure at such an early stage in his research was a questionable ethical decision
Really? How else would you suggest he test his hypothesis that restricted blood flow may be a contributing factor to the disease of MS?
6. to operate on his wife was a questionable ethical decision
This has been discussed elsewhere on the forums here at ThisIsMS. Zamboni did not operate on his own wife. Moreover, it may be the case that it's unlikely that he's personally operated on anyone recently. Have you watched the videos of his interviews? If you were paying attention, then you would have noticed something unusual about his hands. In one video he handles a computer mouse as though he were wearing a ski mitten. In another, he moves his hand over to rest it down on his other arm and it appears to be more of a flop type of motion. If you've read about Zamboni, then you may have discovered that he has an unknown (at least to me) neurological condition. Clearly, this seems to be affecting his hands (or at least one of them). Again, I doubt that he operated on his own wife. However, he may have directed the operation. I see no ethical problems with this if that were the case.
7.the word "liberation" should never have been used to describe his surgery. liberation means to be free of. what a misleading term.
The use of the word liberation by Zamboni is meant that his procedure liberates the blood flow. As far as I know, it has nothing to do with "liberating people from MS." I believe that this is common misunderstanding. Even Dr. Andrews, an IR in support of CCSVI treatment and research, makes this error in his video.
1.2.If there was no double blinded study than how can the placebo effect just be ignored? I am not trying to argue whether people benefited from the liberation procedure or not I just think as people with MS that is a logical question to be asking. I know the 100% thing has been beaten into the ground but to me this claim threw up red flags imeediately. Again I am not saying it is impossible but I think at the least people with MS should be looking at the number with a great deal of suspicion.
3.Correct me if I am wrong, and I am work so I have no time to look it up, but were two treatments not used in combination with each other after both had already gone through clinical trials? For example Avonex had already completed clinical trials and been approved before it was tested in conjunction with Tsysarbi and vice versa.
4. Once again I may be wrong but I remember when CCSVI broke reading articles from Zamboni and his colleagues particpating in numerous interviews with different media sources to "get the word" out about their hypothesis.
5.6. I completly disagree with you on this point. Before Zamboni performed any surgery he needed first to prove that CCSVI actually existed and if so did/does it have anything to do with MS. He is still stuck with trying to prove it exists. Yes I know there are people he has trained and a few others that see blockages in almost all MS patients but according to some of his own trainees these blockages are subjective. Just read how many people on this forum have gone to three different radiologists and gotten three different results. Of course the radiologist that finds the blockages are the ones immediateyl given the accolades but for me I would want to know why this one lone radiologist saw blockages no one else could see. Anyway I guess we will just disagree on this point.
7. I stand corrected if Zamboni did not name his procedure the "liberation procedure". However zamboni had to know what that term triggered in people's minds. Maybe I am wrong in assuming this but when people post they are going to get "liberated" I do not think they are referring to liberating the blood flow to their brain.
Once again I am not saying that Zamboni may not be on to something and this is just one person's(me) perspective on CCSVI. I want Zamboni to prove to other researchers how he identifies CCSVI in people with MS but I am tired of hearing excuse after excuse from Embry and others when he fails to do it.