As far as I know, no gene has been isolated that points conclusively towards MS. Worse still, most of the study was looking for genes responsible for immune regulation, while per CCSVI, you will not find issues with those genes.
Actually, that's not true. According to a new study, the copy number variations located in the HLA locus chromosome 6p21.32 --the locus which is already studied and found related to MS--also contain CNVs for venous malformations found in CCSVI.
Conclusions: The CNVs contained in the HLA locus region in patients with the novel phenotype of CCSVI/VM and MS were mapped in detail, demonstrating a significant correlation between the number of known CNVs found in the HLA region and the number of CCSVI-VMs identified in patients. Pathway analysis revealed common routes of interaction of several of the genes involved in angiogenesis and immunity contained within this region. Despite the small sample size in this pilot study, it does suggest that the number of multiple polymorphic CNVs in the HLA locus deserves further study, owing to their possible involvement in susceptibility to this novel MS/VM plus phenotype, and perhaps even
http://www.fondazionehilarescere.org/pd ... -final.pdf
other types of the disease.
I agree with Mark W 100%---Whether or not "normals" have CCSVI is not the issue. We see predispositions to heart disease, carotid artery disease, and stroke in many "normals" as it relates to elevated C-Reactive protein and carotid artery luminal thickening, yet they do not develop full-blown stroke or heart attacks. Some have transient ischemic attacks that happen once and never return (benign arterial conditions) Yes, there are environmental issues involved in developing stroke and heart attack--BUT THAT DOES NOT PRECLUDE these patients from having their carotid arteries or heart treated with angioplasty, and then being put on special medications, diet and exercise programs.
I'm afraid is we go round and round regarding who has CCSVI, and if we find it in some "normals", we miss the forest for the trees. People already have MS...they need help now, and need to have their venous issues addressed.
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS