Direct-MS wrote:...The results were 13/44 (30%) of family members had CCSVI and 24 of 101 (24%) of non family members had CCSVI. The total for all healthy controls was 37/145 with CCSVI (25.5%)...
MarkW wrote:Choosing people without MS as the healthy controls for MS trials is not logical. Think about the basics of MS - it has an underlying genetic predesposition which is yet to be fully understood and documented. As a minimum healthy controls should be genetically tested to exclude subjects with genes, which may lead to development of MS. More cost I know, when we are still asking do pwMS have restricted veins.
MS is a truly complex disease.....................
As far as I know, no gene has been isolated that points conclusively towards MS. Worse still, most of the study was looking for genes responsible for immune regulation, while per CCSVI, you will not find issues with those genes.
Conclusions: The CNVs contained in the HLA locus region in patients with the novel phenotype of CCSVI/VM and MS were mapped in detail, demonstrating a significant correlation between the number of known CNVs found in the HLA region and the number of CCSVI-VMs identified in patients. Pathway analysis revealed common routes of interaction of several of the genes involved in angiogenesis and immunity contained within this region. Despite the small sample size in this pilot study, it does suggest that the number of multiple polymorphic CNVs in the HLA locus deserves further study, owing to their possible involvement in susceptibility to this novel MS/VM plus phenotype, and perhaps even
other types of the disease.
I'm afraid is we go round and round regarding who has CCSVI, and if we find it in some "normals", we miss the forest for the trees. People already have MS...they need help now, and need to have their venous issues addressed.
I'm afraid we go round and round regarding who has CCSVI, and if we find it in some "normals", we miss the forest for the trees. People already have MS.. they need help now, and need to have their venous issues addressed.
cheerleader wrote:Actually, that's not true. According to a new study, the copy number variations located in the HLA locus chromosome 6p21.32 --the locus which is already studied and found related to MS--also contain CNVs for venous malformations found in CCSVI.
Users browsing this forum: No registered users