I was diagnosed almost 4 years ago. I spent almost 3 years on ReBif, and my neurologist wasn't happy the last year of it w/ my MRI scans, and I was getting worse, so he talked me into Tysabri. I've been on it a year now.
Honestly, I hate being on Tysabri. It's not a problem w/ getting the IV's. I just think it's a "dangerous" drug w/ lots of known side effects, pretty serious ones. Right now my ins just switched, and we're having trouble getting me signed up on the new ins, and I don't really care, because I don't want to be on it! LOL
But if your friend has had good results from Tysabri, then that's probably not much help.
I should say that I've had 2 MRI's since starting Tysabri, and my neurologist was happy w/ the scans, but I don't feel any dft. He couldn't believe it 6 months ago when he saw the scans and assumed I was doing great and walked into the exam room saying, "So! How do you feel?" and I said, "Exactly the same."
I should also say that he diagnosed me w/ RRMS, and I have always felt that that was wrong. Personally, I think it's PPMS (if you don't know the difference, I can explain more later). That may have something to do w/ it. I'm on drugs because I'd rather do something than nothing, but I don't really like the Tysabri.
I'm scheduled to go to Albany in mid-Oct for testing and possible treatment for CCSVI. I'm trying to keep that separate in my head from the question of whether or not I should stay on drugs. I think most (although I have no idea of the #'s) people who get the venoplasty stay on their drugs. So it's not definitely an either/or situation. You can do both.