there will be a few of those head scratcher studies that might make more sense within the vascular paradigm. I'd seen that study and there are actually more on venous thrombosis in MS-
Here's 2 more patients after LP
http://content.karger.com/ProdukteDB/pr ... &doi=47949
Here's a woman where contraceptives are considered at fault:
Here's another woman-
Granted, this is not the majority of MS patients, but it is interesting to note venous thrombosis in MS. Another head scratcher is high liver enzymes in MS. Many studies on that, and even prior to DMDs, some pwMS present with high liver enzymes.
My best guess has been that the coagulation cascade is initiated after a breech of the blood brain barrier in the MS brain, due to venous congestion. That's what I saw in my husband at his first flare (his blood numbers indicated this), and that's what got me looking at these connections to blood and the endothelium.
Here's some info on the coagulation cascade, if you're interested. It explains the activation of thrombin and fibrin (those fibrin cuffs in the MS brain are another indicator)
http://themedicalbiochemistrypage.org/b ... ation.html
fascinating stuff, and I'm glad to know more doctors are looking at this connection now-
Here's the Neurology Dept at Lousiana State Univerisity--MS as a Vascular Disease, from 2006. Lots in here on cerebral endothelial cells
http://www.shreveportphysiology.com/Ale ... MS.pdf.pdf