Cat: If this were the case, do you know why my oxgen levels are always deemed fine? Even when having a very strong upleasant incident where I was skirting blacking out and feeling like I was having a stroke (I wasn't, they've no idea what it was) they've been judged fine by the paramedics
Kleiner: You are definitely not alone x
You had a peripheral blood draw for the oxygen measurement. And in the body the blood oxygen level would most likely be normal. In the brain Oxygen ( and glucose & hormones , etc ) comes in through the arteries, arterioles and into the capillaries that feed the brain cells (axons & other types of supportive cells)The brain cells send signals during "thinking" that demand more of the things that they need (Hubbard describes this as part of his fMRI experiments) Then the brain "uses" the oxygen, glucose and other things to power the cell activity and then CO2 and other waste products of cell metabolism are excreted though capillary venules into veins, and here's where it gets trick------
1.In a normal ( non-CCSVI )brain it goes back to the right heart and to the lungs ( where CO2 is exchanged for O2) and to left heart and back into the other parts of the body ( all organs and cells) via the Aorta- at the same time the digested food puts glucose simultaneously put into circulation. Of course we have other things occuring in other places such as hormones from glands, and wastes being filtered in the kidneys and liver.
2.In the CCSVI person the brain venules drain into veins and there are a few blockages or partial blockages ( the body can normally handle a small blockage- the CCSVI seems to occur when 1 or more blockages occur- So reflux occurs ( blood flow going the wrong direction) this causes turbulance in the flow and blood taking "alternate routes" In the mix that this causes the blood would be lower in oxygen, and glucose too.
So instead of IN and OUT - it goes IN and tries to exit - the normal routes(more than 2 are impaired bysomething) and the blood gets re-routed taking longer than normal too- the longer this takes and the more the blockage the worse the problem. Also the location of the blockages seem very relevent too and may involved the spinal cord.
Once the deoxygenated blood gets back to the heart it goes to the lung and gets Oxygen and this is pumped all over- they test the wrist vein ( or artery depending on the test)and would get a "normal value"- To know the brain oxygen vs the peripheral oxygen they would have to test both areas at about the same time.
So you can very well have a lower than normal brain oxygen level compared to the rest of your body due to blockages in the neck
In some liver diseases a similar cause of malfunction was recorded- I believe Budd Chiari is a venous malformation like a web in the portal(liver) vein and it causes liver malfunction because the liver blood can not empty the normal way and has to find alternate routes.
This same rational would be the reason that you could have a normal serum iron ( circulating iron) or even low (anemia) and still have an elevated Brain iron. There have been 2 theories on the cause of the increased iron-maybe even more. Bahkri (Harvard) and Zamboni (Ferrara) have done papers proving this higher than normal brain iron, this is echoed with the SWI type MRI scans that measure brain iron.
The symptoms of MS must come from multiple malfunction of the brain due to these conditions- lower than normal oxygen, lower than normal glucose, higher than normal brain iron, maybe iron oxidation and release of free radicals, maybe axons short circuiting do to the metal , damaged endothelium, damaged myelin and axons And then add in a few things that change like hydration, position( depending on where your blockages are), hormones of pregnancy ( hormones change veins and blood volume positively), vasodilators ( foods and meds)and vaso constrictors ( caffeine and smoking are bad) , plus a host of other regulators such as the glands located in th brain and you can see how it gets quite complicated.
But honestly, be hope filled- they will make many strides fast once the whole CCSVI vein part -debate gets accepted - after the present clinical trials come out. Once they get more people on board the other things will be examined and sorted out. Its very exciting and I am very hopeful for the future of MS treatment.
Hope this helps explain some of what you are experiencing and help you understand some of the theorized mechanisms.