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This just arrived in my emails and it sounds just like my friend;
Kate commented on CSF and Cerebellar Symptoms in Alzheimer's, Parkinson's and MS.
in response to uprightdoctor:
The cerebellum may be affected in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Chiari malformations and Dandy-Walker syndrome due to obstruction of CSF flow in the foramen magnum and upper cervical spinal canal.
Hello Dr. F, I am a young woman with Chiari 1 for which I had decompression surgery (laminectomy only, my surgeon chose not to go through the dura) a year ago. My surgery was not successful, and my symptoms are worse than before my decompression. I believe that I have a problem with the dynamics of my CSF. I can actually feel this pressure change happening in my head. There is an obvious pressure shift when I change positions or bend over, accompanied by a strong throbbing sensation. In addition, I experience pressure that builds through the day, and relieves over night. This process happens every day, and leaves me debilitated from severe pressure by late evening, until such a time that I can be horizontal long enough to "reset" the high pressure. My current CINE flow MRI says I have no definite detectable CSF flow in the fourth ventricle or cerebral aqueduct, and that my fourth ventricle is effaced. I also have "minimal flow" to the optic tracts - which is perhaps a cause for the constant pressure in my eyes, and pain with eye movement? Also, I have recently developed several perineural cysts in the cervical spine area, (in addition to the thoracic, lumbar, and sacral perineural cysts I have) and an area of T2 weighted hyperintensity in the C2 vertebrae. Basically, I am a mess in there! I have constant pain and pressure...but even worse, I am starting to have very common MS symptoms, such as eye pain, intentional tremors, fatigue, and muscle spasticity. I am on a mission to find some treatment for my CSF abnormalities before it further damages my central nervous system. My neurosurgeon feels that my Chiari decompression was adequate, despite my abnormal CINE flow results. He does not want to do anything except treat me with gabapentin and pain medication. Of course, I do not find that acceptable - I want to solve the problem! I believe very strongly that a complicated relationship between my Chiari, and CSF flow are the root of my body's issues. Until I found this blog, I have had no validation of that suspicion. I thank you for writing this blog. Do you have any advice for me? I am willing to travel to a doctor who is knowledgeable about CSF dynamics and Chiari patients. Thank you so much for your time!
Interested to hear your thoughts Dr F, Nigel
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