I would like to argue that there is less chaos in CCSVI induced MS. While all the different combinations of restrictions and defects can explain the grab bag of symptoms that is MS. At least it can claim that lesions follow along channels and tributaries of the blood.
I prefer that to autoimmune theory which says that the lesions can appear anywhere in the brain or CNS following no pattern at all. What causes this? They do not know? Why do the symptoms appear as they do? They cannot say. Is there anything that can be done? <shoulder shrug>
My understanding is that the refluxed flow is different according to what veins are blocked and just how severely they are blocked. The MS brain lesions are definitely aligned with that individuals refluxed flow would vary. This is not chaotically but could vary drastically.
The causes of symptoms can be multiple-
Some are symptoms of MS and some are symptoms of CCSVI- and they ARE connected.
Some, like brain "fog", headache, fatigue and cognitive (memory, thinking, etc) these symptoms can be attributed to hypoxemia- This is a low grade hypoxemia-Oxygen level low enough to cause symptoms but not low enough to make you pass out. Think of it like being in a room with toxic paint and no fresh air- But remember if the blood oxygen level is measured at the wrist ( artery) it will be normal, the brain O2 level would be lower, due to slow emptying. Also there can lower than normal brain glucose too. No food for cells- starvation of cells = impairment and damage.
Motor symptoms can be caused by multiple causes too- impaired oxygen levels of the spinal cord (hypoxemia) and/or lower glucose(hypoglycemia) than normal- so the fuel is impaired for function of the parts. It does seem that more motor symptoms would be aligned with blocked Azygos but its not that simple.
Then you have the actual lesions- these lesions are from damage from shear stress on the epithelium of the venules( vein walls are designed for flow going one way -"OUT") -inflammation occurs,iron is left (the iron is from Red Blood Cells) and and consequently demyelination. The role of the immune system is not clearly understood at this point.
It could be altered simply by being chronically overworked. Certain parts of the WBC's (the immune systems parts) are turned on into"overdrive" due to the body signaling need. This is seen in multiple trauma, severe infection, burns, etc. (These examples are of acute need not chronic need). The immune system cells ( all different kinds of WBCs) job is to identify an invader or poison or waste or debris and remove it. Next it prepares it for healing (scar formation to prevent further "invasion") .
In CCSVI thats a tall order......there are damaged cells, iron ( also seen as ferritin and hemosiderin) and other wastes and they get made and try to do their job and sometimes in the brain they too stick around too long. But remember they are designed to work well with normal oxygen levels and normal glucose levels of a healthy draining vascular system not one with an impaired "rinse cycle". The immune system can not function normally in an impaired environment.
If the CCSVI ( impaired emptying of the used blood from the brain) occurs from birth ( as it is theorized)then that the problems start then( at birth), and then depending on the location, and severity of the blockages the amount of damage would vary drastically Zamboni saw that this was true. The sickest people had the worst blockages. In CCSVI patients there is such a wide variety this explains why MS has such variety too.
The lesions could be minimal or diffuse, slow to progress or very fast. The list of symptoms would be pages. And it is. So are the songs of MS.
CCSVI ties it all together. It connects the plumbing to the wiring. Not all of the details are proven yet but we are closer to the answers and I believe in my lifetime they will be.
I beg to differ with you but the immune system does not "go rogue" without a cause. Its a system based on signals and reactions. In MS we never see a raised ANA as in all the other autoimmune illnesses such as Lupus, Rheumatoid disease, etc. They tested every organism and no one in 70 years+ could find a "trigger".
So I do not believe it is an Autoimmune disease, It has an immune component as a reaction to an impaired venous drainage. If you stop the CCSVI ( by opening the veins) I'll bet the immune system will return to normal over time. Also remyelinazation can occur but takes many months
I agree to disagree with you Jugular. And we will see in short order. I can't wait.