Urinary hemosiderin detection for CCSVI

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Urinary hemosiderin detection for CCSVI

Postby Taurus » Sun Oct 10, 2010 9:05 am

I have heard that simple Urinary hemosiderin test could be used for detecting CCSVI. Any comments please :roll:
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Re: Urinary hemosiderin detection for CCSVI

Postby GuRu » Sun Oct 10, 2010 9:49 am

Taurus wrote:I have heard that simple Urinary hemosiderin test could be used for detecting CCSVI. Any comments please :roll:



Its Posible, here are detail:
This test detects hemosiderin in urine. Hemosiderin is a pigment formed when hemoglobin breaks down. This test
is used to evaluate and manage disorders involving the destruction of red blood cells[1]. This test may also be
used to evaluate for suspected chronic venous insufficiency[2].
What are other names for this test?



http://www.muschealth.com/lab/labtest.aspx?id=150303
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Postby cheerleader » Sun Oct 10, 2010 10:40 am

Hi Taurus-
I wrote about this on the CCSVI Facebook page...
Dr. Zamboni noted the high levels of hemosiderin in urine of those with chronic venous disease, and also in pwMS during an exacerbation. I wrote about this in relation to the neurologists' recent study testing ferritin levels in CSF as an inappropriate biomarker. Ferritin is more useful in testing for stroke or cerebral hemorrhage, not ongoing chronic venous disease.

But Dr. Zamboni never suggested this as a replacement for doppler or venography to test for CCSVI....he was noting the correlation to CVD in his paper: The Big Idea--
http://www.ncbi.nlm.nih.gov/pubmed/17082306
hope that clears this up,
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby rusty2 » Sun Oct 17, 2010 10:29 am

So I was wondering....For a very long time whenever I had my urine tested for anything there is always the comment that there is blood in my urine. Is this what it means?
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Postby cheerleader » Sun Oct 17, 2010 10:53 am

rusty2 wrote:So I was wondering....For a very long time whenever I had my urine tested for anything there is always the comment that there is blood in my urine. Is this what it means?


Depends on what your doctor is calling "blood", Rusty. Hemosiderin is an iron storing protein....but it is not typically called "blood." Usually, red blood cells are detected in urine, called hematuria, and that's what the docs refer to. Here's more info--

http://www.emedicinehealth.com/blood_in ... cle_em.htm

take care,
cheer
Husband dx RRMS 3/07
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http://ccsviinms.blogspot.com
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Postby Donnchadh » Sun Oct 17, 2010 11:39 am

Cheerleader,

I have been considering going to my GP to ask for this Hemosiderin detection test; it might be a good, if indirect marker for iron from CCSVI.

However, considering that a office visit is going to cost me the same if I ask for one test or a complete panel, does anyone have a complete panel of blood tests to request?

I figure might as well get them all at the same time to get a broader picture of what's going on.

Donnchadh
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Postby cheerleader » Sun Oct 17, 2010 11:48 am

Donnchadh wrote:Cheerleader,

However, considering that a office visit is going to cost me the same if I ask for one test or a complete panel, does anyone have a complete panel of blood tests to request?


Donnchadh

PM Jimmylegs. She is the master of the CBC :)
I know she suggests iron levels, zinc, magnesium, vit D, and she can give you all the target levels.
I suggest the antiphospholipid test (APS), to rule out Hughes or clotting disorders and liver enzymes, to make sure your liver is OK.
Urine hemosiderin is not on the usual menu, and may be pricey. Dr. Zamboni suggested it to back up his analogy of CCSVI and chronic venous disease---don't know that it's really important in the scheme of your personal health....
cheer
Husband dx RRMS 3/07
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http://ccsviinms.blogspot.com
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Postby Taurus » Mon Oct 18, 2010 12:33 am

[quote="cheerleader"][quote="Donnchadh"]Cheerleader,

However, considering that a office visit is going to cost me the same if I ask for one test or a complete panel, does anyone have a complete panel of blood tests to request?


Hi guys
Just to add more confusions to this topic. My MRV and CT Venogram suggests that I have stenosis at C1 levels. My scans are posted at http://liberation-treatment.com/ms-patient-mrv-scans. Even my latest MRI clearly shows stenosis in my both IJVs. I did not have Doppler Test as per the criteria since no body at my present location knows how to do it. Yesterday, I went for hemosiderin test of my urine. It came negative. Any coments please.
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Postby cheerleader » Mon Oct 18, 2010 8:23 am

cheerleader wrote:Hi Taurus-
I wrote about this on the CCSVI Facebook page...
Dr. Zamboni noted the high levels of hemosiderin in urine of those with chronic venous disease, and also in pwMS during an exacerbation.
The Big Idea--
http://www.ncbi.nlm.nih.gov/pubmed/17082306
hope that clears this up,
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby 1eye » Tue Oct 19, 2010 6:11 am

You've probably seen this:

Perivascular iron deposition and other vascular damage in multiple sclerosis.

Adams CW.

Division of Histopathology, United Medical School of Guy's Hospital, University of London, UK.
Abstract

Evidence of damage to cerebral vein walls was sought in 70 cases of multiple sclerosis. Seventy control cases were also examined. The multiple sclerosis cases showed venous intramural fibrinoid deposition (7%), recent haemorrhages (17%), old haemorrhages revealed by haemosiderin deposition (30%), thrombosis (6%) and thickened veins (19%). In all, 41% of all multiple sclerosis cases showed some evidence of vein damage. Occasional control cases showed haemosiderin deposition in the brain but, unlike the multiple sclerosis cases, these were diffuse and almost entirely related to coexistent cardiovascular or cerebrovascular disease. Haemosiderin deposition was common in the substantia nigra and other pigmented nuclei in all cases. It is concluded that the cerebral vein wall in multiple sclerosis is subject to chronic inflammatory damage, which promotes haemorrhage and increased permeability, and constitutes a form of vasculitis.

PMID: 3346691 [PubMed - indexed for MEDLINE]PMCID: PMC1031540Free PMC Article
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