This Is MS Multiple Sclerosis Community: Knowledge & Support

A fascinating paper for MS watchers, not for the faint hearted.

I speculate that this test could be used to:
A - ensure healthy controls in MS trials are not likely to develop MS in the future.
B - provide a pre-screening for CCSVI research. If the blood test is positive one might expect to see early indications of stenosed veins with a venogram.

Kind regards,
MarkW

Abstract-------------------
Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis.

Molecular mechanisms that influence susceptibility to multiple sclerosis are poorly understood. We analyzed peripheral blood gene expression profiles in nine healthy subjects up to nine years before the onset of multiple sclerosis in comparison with 11 age-, gender-, and origin-matched healthy subjects who remained multiple sclerosis-free, and 31 subjects during the first clinical episode of multiple sclerosis. Within the 1051 highly variable genes that differentiated between multiple sclerosis-to-be and multiple sclerosis-free subjects, we identified activation of TCR signaling that triggered the Cbl and MAPK cascade in concert with downstream synergic over-expression of NFAT and MEF2B, but failed to augment the expression of the nuclear receptor gene family members NR4A1, NR2F1, VDR and MEF2B, that further resulted in impaired apoptotic machinery. Comparison between multiple sclerosis-to-be and first clinical onset of multiple sclerosis operating module networks demonstrated the evolution of altered regulation of nuclear receptor-dependent apoptosis. Our findings demonstrating a silent multiple sclerosis trait that is associated with suppressed expression of the nuclear receptor network and inhibited apoptosis of activated T-cells support the role of these transcription signals in the evolution of the autoimmune processes that operate in the pre-disease stage of multiple sclerosis.

PMID: 20079437
Neurobiol Dis. 2010 May;38(2):201-9. Epub 2010 Jan 14.

_________________
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 10 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html

Can you translate that to english please?

(emoticon response aknowledged as annoying but ..had to )

I think this is the same as the one I posted awhile back:
( http://www.thisisms.com/ftopict-12257-nine.html+years )

It has big possibilities. Thanks MarkW.

The closest translation to everyday English is Cece's reference:

http://www.israel21c.org/201006138028/h ... -sclerosis

I think I understand the science (just). Do not bother unless you have time on your hands and a bio-medical background.

I was flagging the paper for CCSVI vascular researchers who may be looking for background in MS.

Kind regards,
MarkW

_________________
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 10 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html

MarkW, I still don't understand the implications fully. Could this end up being a simple blood test? Or is complicated to do the genetic assay whatnot? (Yes, I am just tossing words in there. Cogfog....)

I think too this could be of use for the CCSVI researchers who are looking at the pediatric side of things, because a question was how do you find the kids who are at risk for having this. You can't image everyone, but running a blood test on all the kids of MS parents who volunteer them for it seems reasonably feasible. Then take that group and do the CCSVI imaging.

Hello Cece,
I think it is a complicated blood test for the scientists but just giving blood for the possible MS patient.
In the future:
You are 18 and have instances of MS in your family. You get the blood test and find you are positive. You have a doppler scan which finds stenosis. You have a venogram and venoplasty for venous insufficiency. Maybe you take drugs to adjust your immune system.
You do not develop MS...........................am I dreaming ?

In the short term CCSVI researchers need non MS healthy volunteers. They use the blood test to ensure participants are really non MS, better results for CCSVI therapies.

Kind regards,
MarkW

_________________
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 10 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html

Hi Mark,

I hope things will go like that in the future. Recently, I was thinking of my children. Should I have them tested. How can I get this done?

Now they are aged 12 and 15. I hope things will develope in a couple of years. And then I have no problems getting them screened.

_________________
I'm ready, I'm ready !

Hello Joge,
Patience is needed cos this is very experimental at the moment. Your children are young for MS, so just ensure they get lots of sunshine or oily fish or VitD3 supplement.
I don't have children so have no idea how easy this will be.
Kind regards,
MarkW

_________________
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 10 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html