hi merlyn, i posted in detail in the early days of the CCSVI forum here at TIMS, regarding regular venous insufficiency affecting the legs and feet, as a possible linkage to the CCS variety of VI.
i have trouble linking straight to that post - some kind of glitch i think - so i reposted it to my regimens thread in case you'd like to check it out:
following my usual approach of searching for research on nutritional links to conditions, zinc came up time and again. unfortunately, i recall that you have not had success working on your zinc deficiency (10.9 umol/L) but i hope you will continue to try to get it up into the high teens.
i know you said that high zinc intake messes with the immune system but it's the same problem at both ends of the scale:
"High dosages of zinc evoke negative effects on immune cells
and show alterations that are similar to those observed with zinc deficiency... Zinc is necessary for the normal function of the immune system (6, 12). Even mild zinc deficiency, which is widely spread in contrast to severe zinc deficiency, depresses immunity of humans
...the optimal therapeutic dosage that is required to reverse symptoms of zinc deficiency is still unclear, and the pharmacologic zinc dose should be adapted to the actual requirements to avoid negative side effects on immune functions. Therefore, zinc plasma levels should not exceed 30 µmol of zinc/L
Different groups report suppression of immune functions when the oral zinc intake is 100 mg of zinc/d
you'd only want to take amounts that high on a daily basis for a short time to address deficiency. in 2007 when i got my 8.6 umol/L level, my doc said take 100mg/d for a month. it made me nauseous so i had to break up the dose through the day and it worked. i took it for a bit too long and went up just over 20 at one point (panicked since i did not know about the 30 umol/L limit then).
also... not sure if you're still considering/doing the IP6 thing but that will knock your zinc down quite handily too.. standard diet has too much phytate as it is, leading to a general societal suboptimal zinc status...