I also perfomed a study to disprove Dr. Zamboni theory that MRV is unreliable to diagnose CCSVI because of high false positive and false negative results.
As you can see my right jugular vein (on the left side of the picture) is much smaller then the normal jugular vein on the other side so it is obvious that I have CCSVI based on the above MRV.
A limitation of my study is the limited number of MS patients
( one, me) and no healthy control subjects, which limits the ability to draw
definite conclusions.( so what?) The sample size number was based on the
suggested almost absolute difference in presence of venous
abnormalities between MS patients and healthy controls.
Nevertheless, the present sample size would allow one to find
a difference of 100% or more with a power of about 0.8. In addition,
our results based on MRV have not been confirmed or
refuted by another imaging modality such as Doppler sonography.(Dr. Zamboni standard method to detect CCSVI)
However, my study represents the second largest casecontrol
dataset of MRV in the evaluation cranial venous outflow in MS
patients and no healthy controls so far. Given the fact that the initial
results suggesting that MS is associated with a pathological
venous outflow anatomy , (also confirmed by thousands of catether contrast venography done up to date), presented sensitivity, specificity, positive
and negative predictive values of 100%, my study population
is large enough to confirm these data.
Please let me know if I should publish my study.
Thanks for your attention.