The reduction of MS relapses in preganancy is a well documented phenomenon and the reasons for it are not known. I propose that it is secondary to increased fibrinolytic activity during pregnancy. Fibrinolytic activity is the bloods ability to break down fibrin. I a prevous post, I explain how fibrin may be key in the development of MS symptoms and lesions. http://www.thisisms.com/ftopict-14475.html
One measure of fibrinolytic activity is the level of fibrin degradation products (FDP) in the blood. Logically, FDP should be increased in states of increased fibrinolysis as fibrin is broken down into its degradatation products. This is exactly what was shown in the following study; ‘”Prospective, sequential, longitudinal study of coagulation changes during pregnancy in Chinese women " (Xing-hui et al., International Journal of Gynecology & Obstetrics,Vol 105, Issue 3, June 2009).
Fibrin degradation products were shown to increase progressively in pregnancy and decreased post partum. Consistent with these finding is another phenomenon during pregnancy, the progressive increase in D-dimer levels. D-dimer is another product of the breakdown of fibrin.