plethysmography neck collars (Zamboni)

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: plethysmography neck collars (Zamboni)

Postby MrSuccess » Tue Feb 11, 2014 5:02 pm

Cece , MRI's have a sensitivity and specificity rate of about 98%.

A lot can be missed in that 2%.

I think 70% is a pretty good s & s , for any new tool of detection.

I am confident it will improve as they advance it's use. How can it not
considering the names on that Presentation !

How nice to see Fabrizio Salvi named on this document. I believe he was
the Neurologist involved with Dr.Zamboni's historic original 65 pwMS investigation
of CCSVI. Where would we all be without Fabrizio Salvi's support ? :?:

Well done gentlemen.


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Re: plethysmography neck collars (Zamboni)

Postby Cece » Tue Oct 28, 2014 5:29 pm

Image
I heard that a rocket exploded & had to check to make sure Dr. Zamboni's experiments weren't on it. (They weren't.)
Anyway, I came across the photo of the plethysmography neck collar that will be used in space. Pretty simple design!

Two completely new developments in diagnostics are proposed with Brain Drain (whose project manager is Angelo Taibi, of the Physics and Earth Science Department of University of Ferrara): the plethysmograph (plethysmographic collar), a totally non-invasive and non-operator-dependent device, and the development of a jugular path synchronized with the electrocardiogram, "to derive in a non-invasive way the jugular vein pulsation and to characterize the cardiac impact."

I haven't heard much talk about that latter diagnostic. A jugular path synchronized with the electrocardiogram?

http://www.ccsvi-sm.org/node/2065
http://www.nasa.gov/mission_pages/stati ... /1278.html
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Re: plethysmography neck collars (Zamboni)

Postby ThisIsMA » Sat Nov 01, 2014 7:54 am

I hate to be the bearer of bad news (and I hope I'm mistaken) but according to this article, it sounds like Dr. Zamboni's experiment WAS on the space rocket that exploded. Click on the link below, or scroll down to read the bold text within the article:

http://news.sciencemag.org/people-events/2014/10/things-it-carried-rocket-explosion-destroys-numerous-science-experiments

The things it carried: Rocket explosion destroys numerous science experiments

By David Shultz

29 October 2014


A suite of scientific experiments was lost yesterday evening when the Antares rocket headed to the International Space Station (ISS) exploded 6 seconds after liftoff. The NASA-commissioned rocket, built by Orbital Sciences Corp., exploded on the launch pad at Wallops Island, Virginia, incinerating the scientific experiments on board as well as 748 kg of supplies for the six astronauts stationed on the ISS.

Among the losses was an experiment designed by students at Duchesne Academy of the Sacred Heart in Houston, Texas, to determine the optimal lighting conditions for growing pea shoots in outer space. The plants’ rapid growth and high concentration of nutrients make them promising food sources for extended missions in space.

Another casualty was an experiment using a high-resolution camera to observe the chemical composition of meteors entering Earth’s atmosphere. Meteors are relatively rare and difficult to observe from the ground; one way to solve that problem is to hunt for them from the top down. The camera, developed by the Southwest Research Institute, would have peered out of a window on the ISS to record the light spectrum of the rocks as they streaked through Earth’s atmosphere.

Research into solar sails also experienced a setback due to the explosion. Solar sails are incredibly thin sheets of reflective materials that can harness pressure differences in space caused by the sun to propel a spacecraft without burning fuel. The experiment was intended to test different materials for their suitability as solar sails.

Another experiment dubbed Brain Drain would’ve fitted astronauts on the ISS with high-tech collars to monitor the blood flow in their necks. Astronauts often report headaches and other neurological disorders during their time in space, and scientists from the Italian Space Agency had hoped to learn how blood drains from the brain back toward the heart in the absence of gravity.

The explosion also destroyed 18 experiments by students from across the United States and Canada. The experiments ranged from an investigation of the effectiveness of composting in space to observing how mosquitoes develop in microgravity.
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Re: plethysmography neck collars (Zamboni)

Postby Cece » Sat Nov 01, 2014 2:37 pm

:sad: :sad: :sad: :sad: :sad:
My first thought was if there was any fatalities, and an unhappy reminder of Columbia and other explosions, but my second thought was Dr. Zamboni's experiment. The Italian astronaut who was to conduct the experiment is going up in November.
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Re: plethysmography neck collars (Zamboni)

Postby Cece » Sat Nov 01, 2014 2:45 pm

http://mashable.com/2014/10/28/science- ... explosion/
"We lost quite a bit of research hardware," said space station manager Mike Suffredini. He added that NASA would find another opportunity for the researchers and scientists to fly their experiments to the space station at a later date. "All these things can be replaced and will be over time."
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Re: plethysmography neck collars (Zamboni)

Postby CureOrBust » Sat Nov 01, 2014 6:46 pm

WRONG...There have been two recent accidents with attempted space destinations.
1. The UNMANNED rocket which exploded a few seconds after takeoff. Being unmanned, I doubt the collar would of been on the mission/rocket, as there would of been no-one to wear the collar during a test in space. There were no casualties.
2. The commercial test flight by Richard Branson company which was not for or by NASA, and was not so much for general scientific testing as it was for specific commercial testing for paid passenger flights to space. I think there was a single casualty, and the other test pilot suffered serious injuries.

So in summary, apart from the fact that any accident will affect any following attempts for space travel (possibly for the better due to learning something new) I do not see the collar being directly delayed.
WRONG... :oops:

my best wishes go to the injured pilot for a fast recovery, and to the family & friends the other pilot leaves behind. :cry:
Last edited by CureOrBust on Sun Nov 02, 2014 7:52 pm, edited 1 time in total.
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Re: plethysmography neck collars (Zamboni)

Postby cheerleader » Sun Nov 02, 2014 9:45 am

Right, Cure--2 different incidents. But ThisIsMA is right, too...

Dr. Zamboni's technology, collar and hardware was on the unmanned craft, which was being sent to the International Space Station with other supplies and experiments to be used on the space station---he's tweeted about it, and did interviews for Italian TV.
via google translate:
At this time we are working feverishly with NASA to try to see if we can recover the experiment in a few weeks - said Professor Zamboni - The American space agency is married one hundred percent to the program, has been shown to believe in this very much. " The research team Unife, which includes physicists led by Mauro Gambaccini and cronobiologi coordinated by Roberto Manfredini, had responded to a public call for the Italian Space Agency (ASI) proposing precisely DrainBrain. The project was then selected for the Future space mission, after two years of rigorous selection and testing by several scientific committees in the US.

http://lanuovaferrara.gelocal.it/ferrar ... 1.10208148

In the load were also the materials that would be used in some experiments the mission Futura Samantha Cristoforetti. According to the list of Cygnus cargo published on the website of NASA, the freighter was carrying also Brain Drain, an experiment at the University of Ferrara designed specifically for mission Futura.
The experiment was supposed to test the slowing of the venous return of blood from the brain to the heart due to the absence of gravity, a phenomenon that could be the cause of some neurological problems complained by astronauts after several months stay in Space.
The results would have important consequences on Earth: many neurological diseases such as multiple sclerosis, are characterized by disorders of the cerebral veins.

http://www.focus.it/scienza/spazio/lesp ... yc.twitter

Here's more on NASA's program utilizing Dr. Zamboni's technology, from the NASA site.
http://www.nasa.gov/mission_pages/stati ... /1278.html

The sad thing for me to read, was that the operators destroyed the NASA contracted rocket on purpose, after there were problems detected. Too bad it couldn't have been saved. Just weird that these 2 incidents happened a day a part. Obviously, loss of life is the most tragic thing---but the operators exploded the unmanned rocket to avoid casualties.
http://www.cnn.com/2014/10/30/us/antare ... ?hpt=hp_t2

ugh.
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Last edited by cheerleader on Sun Nov 02, 2014 7:38 pm, edited 1 time in total.
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Re: plethysmography neck collars (Zamboni)

Postby Cece » Sun Nov 02, 2014 12:17 pm

"We are in constant contact with NASA - continues Zamboni - to assess whether and how to overcome various rocks, beginning with the creation of the prototype destroyed as validate it, how to transport it to the US and as a means to send him on the space station." The timing is impossible, at present, hazard a guess, but all is not lost in the disaster of the Antares rocket. "One of the experiments can still be performed aboard the orbiting station - ensures Zamboni - These are analyzed ultrasound cerebral vessels of the astronauts, who were instructed to autoeseguire on themselves a series of tests" guided "by me, As a principal investigator of the program. The objective is twofold: to study the physiology of the cerebral circulation in the absence of gravity and explain the symptoms that bring the astronauts back to Earth. " In other words, the studies of human physiology in orbit allow to "recreate" in a sort of "laboratory" conditions of venous insufficiency and observe the mechanisms. A faint, with the explosion of the freighter, was the necessary equipment to collect and process real-time information. For his part, the President of ASI Roberto Battiston assured that "the experiments will be replaced as soon as possible."

The bolded part to me reads that one of the experiments is ok to go and one needs to be rebuilt. It's the plethysmography prototype that needs rebuilding & revalidating.
Two completely new developments in diagnostics are proposed with Brain Drain (whose project manager is Angelo Taibi, of the Physics and Earth Science Department of University of Ferrara): the plethysmograph (plethysmographic collar), a totally non-invasive and non-operator-dependent device, and the development of a jugular path synchronized with the electrocardiogram, "to derive in a non-invasive way the jugular vein pulsation and to characterize the cardiac impact."

Ok, there's the latter experiment that sounds like it is still good to go forward. That's not nothing but the plethysmography has captivated my interest from day one. I have been waiting to hear what can be done for rescheduling Brain Drain but what Cheer posted sounds like they have to rebuild and revalidate the prototype plethysmography collar. The astronaut who was to conduct the experiment goes up in November and I wonder how long she will be up?
A European Space Agency (ESA) astronaut of Italian nationality, Samantha Cristoforetti is currently training for the second long duration mission of the Italian Space Agency (ASI) on board the International Space Station. She will be a Flight Engineer for Expedition 42 and 43 between December 2014 and May 2015. Samantha is a Captain in the Italian Air Force.

http://samanthacristoforetti.esa.int/
But weren't they going to take measurements here on Earth before the trip and then measurements on the space station. So to conduct that part of the experiment they'd need the prototype done again before the astronauts go up. It would not work to use the baseline on-Earth measurements done by the now-exploded plethysmography collar because it could be slightly different than the recreated one. Or is some of that opportunity already lost if the three astronauts who went up in September had their pre-measurements taken?

Soyuz 41
Crew: Anton Shkaplerov, Terry Virts, Samantha Cristoforetti

Launch: Nov. 23, 2014, 3:59 p.m. EST

Ok it is 21 days and 2 hours until launch.
That doesn't seem like enough time. :(
If it was just a matter of recreating the collar and sending it up on a latter supply rocket, there would be all the time until May to get it done before her mission ends. I would be so happy if this can be pulled off. I can't blame the rocket operator for exploding it because they were probably following protocol or following their own knowledge of what the risks were and that's all beyond my knowledge base to even judge if their actions were correct. I do however very much wish it had all gone according to plan.
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Re: plethysmography neck collars (Zamboni)

Postby MrSuccess » Mon Nov 03, 2014 5:28 pm

how disappointing to hear of both situations. Dr. Zamboni's space experiment - plethysmography neck collars - is delayed but hopefully included on the next NASA trip.

It is MrSuccess' understanding , that all NASA launchs are so fraught with danger , that it is someones job and responsibility at NASA ..... to press a button and destroy the mission should something go so wrong as to endanger a large population . Tough job . Tough decision.

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Re: plethysmography neck collars (Zamboni)

Postby Cece » Mon Nov 10, 2014 11:33 am

MrSuccess wrote:how disappointing to hear of both situations. Dr. Zamboni's space experiment - plethysmography neck collars - is delayed but hopefully included on the next NASA trip.

Check this out:
ISS Expedition Duration
September 2014 - September 2015

Expeditions Assigned
41/42,43/44
http://www.nasa.gov/mission_pages/stati ... /1278.html
I thought the mission was through May and it was only 41/42? Now it is extended? Research delayed but not research denied? Or was it always through September?
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