Vit D3>125nmol/L min in blood. FIRST SMALL STEP for pwMS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Minerals and Vitamin D3

Postby MarkW » Fri Dec 02, 2011 11:30 am

Hello Jimmylegs,
I am hoping you will post a list of minerals to check when taking vit D3 (Ca/Mg/Zn plus?) and a target range for pwMS on an average western diet. I think you are a vegatarian so you probably get Zinc which is missing from English food (due to modern growing methods).
I am just trying to convince pwMS to take Vit D3 and want to avoid making my message more complex.
Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Research on Vitamin D3

Postby MarkW » Fri Dec 02, 2011 11:43 am

This is the part of research I do not understand. There is 'emerging evidence' for Vit D3 in pwMS so should you spend 5 pence/cents a day on giving all pwMS a dose of 5000iu/day or wait many more years to conduct more research to be absolutely sure ????
Your neuro will be a rarity if they put everyone diagnosed with MS on Vit D3, very sad fact.
Useful paper for getting lots of papers on Vit D3.
MarkW

Recent Pat Inflamm Allergy Drug Discov. 2011 Nov 28. [Epub ahead of print]
Therapeutic Use of Vitamin D and its Analogues in Autoimmunity.
Fletcher JM, Basdeo SA, Allen AC, Dunne PJ.
School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. jean.fletcher@tcd.ie.
Abstract
In recent years there has been great interest in the role of vitamin D in a number of diverse human diseases including autoimmunity, allergy, infection, cardiovascular disease, chronic lung disease, transplantation and cancer. Vitamin D is best known for its role in calcium metabolism; however it also has potent immunomodulatory effects. Epidemiological studies suggest that vitamin D deficiency may be a significant risk factor for many diseases. Furthermore, there is accumulating evidence from experimental studies that vitamin D has anti-inflammatory effects. Recent studies have indicated that a surprisingly high proportion of people are vitamin D deficient, suggesting that vitamin D supplementation may be of benefit to human health. This review will focus on the role of vitamin D in autoimmune diseases, including multiple sclerosis, rheumatoid arthritis and diabetes. We will review the epidemiological and experimental evidence for the protective effects of vitamin D in autoimmunity, as well as the preliminary vitamin D intervention studies and the most recent patented vitamin D analogues.
PMID: 22122009
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Vitamin D3 Before and After De-Stenosis.

Postby MarkW » Thu Dec 08, 2011 2:39 pm

Another piece in the jigsaw of MS. Please remember to take 5000iu/day as a maintenance dose. Then check to see that your level is in the correct range. (Target range for pwMS is 100 to 150 nmol/L of 25-hydroxyvitamin D in blood (measured in Feb-Mar not Aus/NZ)).
The BBC gives a comprehensible report of the latest research:
http://www.bbc.co.uk/news/health-16086004
The thread should answer most questions. PwMS may have this gene but taking Vit D3 is important, and will reverse the problem of low vitamin levels. Vit D3 is a cheap and simple way to counter one of the the factors provoking MS.
MarkW

PS I take 10k iu/day after a test, in case you wondered.
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Vitamin D3 Answer for Mr Success

Postby MarkW » Fri Dec 09, 2011 9:10 am

Mr Success asked:
regarding the Oxford study .... it would be interesting to know the names of all of
the collaborating research scientist's. I'm certain everyone reading this , is asking themselves the question ..." What are my vitamin D levels ? "
Is there anyway to determine your D level .... without visiting your doctor ?
It is information like this ..... that MrSuccess cannot wait for '' WATSON '' to digest and give us an opinion on.
It DOES tie in with working shiftwork ....... the answers are slowly coming into focus.

The test for Vit D (25-hydroxyvitamin D) is a blood test. So you need a clinic to draw blood and send it to a lab. Other methods (pin pricks etc) are offered but they are less reliable.

Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Vitamin D3 Before and After De-Stenosis for CCSVI

Postby MarkW » Fri Dec 09, 2011 9:49 am

Cheer wrote:
"here's a note I wrote up on FB regarding the affects of vitamin D levels on cerebral vasculature. Low vitamin D levels in serum are related to brain atrophy in neurological disorders".
Thank you for all the background info Cheer.
I stick to a simple message:
TAKE 5000IU OF VITAMIN D3 A DAY.
The researchers will probably take 5 years to catch up with this. 5 years of MS decline is too much to risk against the price of this cheap supplement.
Kind regards,
MarkW

PS Hope you don't mind me copying your post. As the saying goes: copying is flattery.

Cheer's Quote:
From Scientific American:
http://www.scientificamerican.com/blog/ ... 2010-07-12

Low vitamin D in Parkinsons and Dementia--

"The first study, led by Paul Knekt and colleagues at the National Institute for Health and Welfare, Finland, examined levels of vitamin D in the blood of 3,173 Finnish men and women aged 50-79 determined to be free of Parkinson's disease at the start of the study. The researchers then examined the incidence of Parkinson's disease in these participants over a 29-year follow-up period. They found that participants with the highest levels of vitamin D (more than 50 nmol/L) had a 65 percent lower risk of developing Parkinson's disease than those with the lowest vitamin D levels (less than 25 nmol/L).

In the second study, David Llewellyn of the University of Exeter and colleagues examined vitamin D levels among 858 Italian men and women age 65 and older. They found that more than half of the participants with dementia were vitamin D deficient .
___________________________________________________________

And here is news of a study at SUNY Buffalo, from earlier this spring:

"Low vitamin D levels may be associated with more advanced physical disability and cognitive impairment in persons with multiple sclerosis, studies conducted by neurologists at the University at Buffalo have shown.
http://www.sciencedaily.com/releases/20 ... 153955.htm

Their results, reported at the American Academy of Neurology meeting, held earlier this month, indicated that:
The majority of MS patients and healthy controls had insufficient vitamin D levels.
Clinical evaluation and magnetic resonance imaging (MRI) images show low blood levels of total vitamin D and certain active vitamin D byproducts are associated with increased disability, brain atrophy and brain lesion load in MS patients.

A potential association exists between cognitive impairment in MS patients and low vitamin D levels."

__________________________________________________________

Now, how could this situation be compounded when we consider CCSVI as a factor in developing MS? I believe it's all about protecting the brain from further vascular damage. Here's a wonderful research paper on how Vitamin D can provide "vasculoprotection" of the brain.

http://ddr.nal.usda.gov/bitstream/10113 ... 182071.pdf

"Vitamin D may help to protect against cognitive deterioration and dementia, specifically, vascular dementia and Alzheimer’s disease, through vasculoprotection (Lind et al., 1987; Burgess et al., 1990; O’Connell et al., 1997; Pfeifer et al., 2001; Wang et al., 2001; Zittermann et al., 2003; Wang et al., 2008a,b), preservation of neurons (Sutherland et al., 1992; Landfield and Cadwallader-Neal, 1998; Brewer et al., 2001), and protection against risk factors for cognitive dysfunction (Lind et al., 1987; Burgess et al., 1990; Hypponen et al., 2001; Pfeifer et al., 2001; Li et al., 2002, 2004; Zittermann et al., 2003; Bisc- hoff-Ferrari et al., 2004; Wang et al., 2008a,b).

We did observe an inverse association between 25(OH) D concentration and presence of white matter hyperintensities and large vessel infarcts; indicators of cerebrovascular disease (Buell et al, in preparation). Consistent with this finding, we observed a positive association between vitamin D concentrations and the integrity and structural arrangement of white matter fibers using diffuser tensor imaging. Further studies designed to provide information on the temporal relationship of 25(OH)D and brain morphology are warranted.
420 J.S. Buell, B. Dawson-Hughes / Molecular Aspects of Medicine 29 (2008) 415–422"
=====================================================
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Jeff's Vitamin D3 level

Postby MarkW » Fri Dec 16, 2011 11:03 am

Cheer wrote (in thread chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic18680.html):
Get your serum D3 levels tested regularly.
Jeff's were 40nmol (low) a couple years ago, and now are around 75 (high normal)
He gets sun and takes 4,000IU daily. It's working for him, but everyone is different and should work with their doctors.

Doctors (in USA and most other countries) quote averages. For example they say 75 is high normal. I have studied the best level for Vitamin D in pwMS. It is 100 to 150 nmol/L of 25-hydroxyvitamin D in blood (measured in Feb-Mar not Aus/NZ). This target level is derived from looking at Vit D levels in healthy people who work outside for much of the time. We should remember that humans have evolved to live outside much of the time. Only in the last few centuries do we live and work inside. In recent years SPF 50 is a widely used sunscreen.
I recommend that Jeff increases his Vit D3 intake so that he reaches at least 100 nmol.
Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: TREAT YOURSELF - Vitamin D3 Before and After De-Stenosis

Postby MarkW » Sat Dec 24, 2011 10:28 am

If you are busy giving presents to others, treat yourself. Buy some vitamin D3 and take one 5000 IU capsule a day until Feb/Mar 2012, then get tested.
Best wishes,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: TREAT YOURSELF - Vitamin D3 Before and After De-Stenosis

Postby coach » Fri Dec 30, 2011 12:30 pm

MarkI think vitamin D3 is important and particularly for me since I stay indoors mostly but sm married to a guy that looks at the risks and he was quick to point me to this article.
http://www.msnbc.msn.com/id/45325473/ns ... om/toolbar
Would like to get your thoughts.
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Re: TREAT YOURSELF - Vitamin D3 Before and After De-Stenosis

Postby MarkW » Sun Jan 01, 2012 6:16 am

Hello Coach,
This research does not inform us what was taken (variety of vit D); what was measured and when; did subjects include pwMS ? who where controls ?.
My advice is very focussed to pwMS.
- Take 5 to 10,000 IU a day of D3. It is safe for adults.
- Target range is 100 to 150 nmol/L of 25-hydroxyvitamin D in blood (measure in Feb-Mar). Lifeguards in St. Louis have 150 nmol/L naturally.
I stand by my advice for pwMS.
Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Scots need Vitamin D3 Before and After De-Stenosis.

Postby MarkW » Sun Jan 08, 2012 9:51 am

Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: TREAT YOURSELF - Vitamin D3 Before and After De-Stenosis

Postby coach » Mon Jan 09, 2012 6:21 am

I'm in agreement with you Mark. Since I don't get outside much these days I take a supplement for D3.
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HELP YOURSELF-Take Vitamin D3 Before and After De-Stenosis.

Postby MarkW » Sat Jan 21, 2012 9:21 am

bump...............MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Concerns over vitamin D deficiency-1 in 4 toddlers affected

Postby MarkW » Wed Jan 25, 2012 6:07 am

http://www.bbc.co.uk/news/health-16700833
Even UK Government is realising the problem for children.
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: HELP YOURSELF-Take Vitamin D3 Before and After De-Stenos

Postby ton » Thu Jan 26, 2012 2:55 pm

Hi Mark,

THE RESULTS OF AN ANALYSIS THAT I DID IN NOV 2011 WAS LESS THAN 4.0 NG / ML FOR 25-HIDROXIVTAMINA D2 AND D3
MY NEURO PRESCRIBED CALCITRIOL (1CAPSULA OF 0.25 MG EVERY 48 HOURS)

what do youThink?
TON
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Re: HELP YOURSELF-Take Vitamin D3 Before and After De-Stenos

Postby jimmylegs » Thu Jan 26, 2012 3:50 pm

ton - if it's going to be a supplement it should have been calcidiol not calcitriol, in my non-pro opinion.
you measure 25hydroxycholecalciferol aka 25(OH)vitD3 aka calcidiol because it is your body's stores of raw material for making 1,25dihydroxycholecalciferol aka 1,25(OH)2vitD3 aka calcitriol.
your body makes calcidiol into calcitriol via hydroxylation in the kidneys.
elevated calcitriol is one of the things you need to watch for wrt vit d3 hypercalcaemia risk (hypercalcemia - what kills the rats when vit d is used as poison)
i used a topical calcitriol ointment briefly and my serum levels went through the roof. never touch the stuff now.
consider getting your 25(OH)vitD3 level up to the 50 ng/ml ballpark...
if your levels were that low you might consider testing calcium magnesium and zinc as they all need to be in good shape for proper vit D absorption and use.
i don't have a calcium target for you off the top but magnesium, aim for minimum .90 mmol/L and for zinc, aim for as close as you can get to 18 umol/L. not higher than 19.
hth
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