NZer1 wrote:From Helena Webb
Ingested vitamin D suppresses the innate immune system, and, in the short term, people often feel better as a result of taking it.
In the long term (10-20 years), the ingestion of this steriod allows the underlying disease to proliferate unhindered, ensuring the disease severity will progress, year by year.
Before anyone stops taking Vitamin D, Dr. Trevor Marshall has a THEORY that 25(OH)D competitively binds to the Vitamin D Receptor displacing the active form of vitamin D, 1,25(OH)D based on a concentration gradient.
While this may turn out to be true, there is no evidence yet that it is. And there is, as I believe Dr. Veith notes at the end of the video, evidence to the contrary in humans with Type 1 Vitamin D Deficient Rickets who cannot produce 1,25(OH)D that this does not happen.
I would think that until Dr. Marshall's THEORY is proven, maintaining adequate levels of Vitamin D is warranted.
Yehuda Shoenfeld, et alia: wrote:Adequate vitamin D status seems to be protective against musculoskeletal disorders (muscle weakness, falls, fractures), infectious diseases, autoimmune diseases, cardiovascular disease, type 1 and type 2 diabetes mellitus, several types of cancer, neurocognitive dysfunction and mental illness, and other diseases, as well as infertility and adverse pregnancy and birth outcomes. Vitamin D deficiency/insufficiency is associated with all-cause mortality.
Vitamin D effects on musculoskeletal health, immunity, autoimmunity, Autoimmunity reviews, 2013 Mar 28.
MarkW wrote:I use iHerb.com in California, USA for supply of Vit D3 5,000iu as high strength are not available in UK and many countries in Europe. Many brands of D3 are stocked by iHerb (http://www.iherb.com/Vitamin-D-5000-IU).
My iHerb code- WAL561 -is now worth $10 off for anyone shopping at iHerb for the 1st time. You will save $10 off your 1st iHerb purchase of $40 or more! Or $5 off on smaller orders.
You may find D3 cheaper (please let me know if you do). iHerb ships to Europe, but remember you may have to pay local sales tax (VAT is 20% in UK).
I will not benefit from anyone using this code as all discounts I receive are passed on to pwMS at OMSTC http://www.omstc.org
This is an article well-worth printing out and handing to your neurologist or GP!Pierrot-Deseilligny and Souberbielle wrote:Current Practical Clinical Implications
The aim of this preventive supplementation is to raise a spontaneously low 25-OH-D serum level to the physiological range and then to maintain circulating vitamin D just above the 75–100 nmol/liter zone (see above) indefinitely.
NZer1 wrote:Ed I have seen articles that show Vitd3 and Magnesium plus Zinc and copper are necessary as a synthesis group to achieve some 325 genetic actions and that the Magnesium depletion and deficiency is impacting health. I think this is what Jimmylegs has also been showing.
The Vit D3 and Calcium levels interaction and the way VitD3 becomes a sensor for calcium load is also noted. I will find research and articles as I look into it more. I do see that research is sparse so it is often called a theory!
My searching began from a link I was sent;
http://drcarolyndean.com/2013/03/dean-o ... um-basics/
NZer1 wrote:Agreed Ed, the link to Calcium appears to be a reverse situation where there is an excess of calcium available and used and stored in the body and that causes a blocking effect to the Vit D absorption process I have to read more to understand and language this better.
NZer1 wrote:The magnesium,zinc and copper also play a role in the absorption and production/synthesis of Vit D therefore making it available.
NZer1 wrote:I think from recent discussions the Vit D link is more about the symptoms and their severity during the course of life and for PwMSers if the Vit D is low the symptom expression is often higher. The cause of MS is one part of the picture and management of the symptoms is possible but management of the disease is not, until it is known.
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