This Is MS Multiple Sclerosis Community: Knowledge & Support

New Piece of Alzheimer's Puzzle Identified
Dec 2, 2010

Researchers from the Mayo Clinic found that endothelial dysfunction increases production of proteins that provide the raw material for the amyloid plaques seen in the brains of people with Alzheimer's disease...

The study may help explain how exercise benefits cardiovascular and brain health. Previous research has shown that exercise can delay or prevent cognitive impairment.

"There is a lot of literature showing that every time you exercise, you stimulate the endothelium to produce more nitric oxide. What we have identified in this paper may help explain the reported (cognitive) benefit of exercise," Katusic said.

More at:
http://tinyurl.com/38ruv88

I have not seen this discussed in other threads so hope I'm not dupplicating info.

Rox

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Diagnosed with Transverse Myelitis in December 2008. Inflammatory demyelination of the spinal cord (c3-c5). No MS, but still CCSVI.

great find, TMRox.

This is the first post on here, Rox. Thanks for mentioning it -I got the full Mayo paper earlier this week. There are a few more coming out, discussing nitric oxide, endothelial dysfunction and neurovascular disease. Lack of NO begins a cascade which impairs and weakens the endothelium (the cellular lining of all our blood vessels which is maintained by NO) and can lead to deposition of plasmic particles into the brain.

the Mayo clinic study is released Dec. 2 in Circulation-
http://www.businessweek.com/lifestyle/c ... 46747.html

This was the idea I started following in '08 with MS...reading the vascular research just made so much sense in what I had seen with Jeff's diagnosis. It's been exciting to see talk with the doctors of the ISNVD regarding the connection in neurovascular disease. To them, it makes sense. The cardiovascular system affects all organs--blood in---blood out. Perfusion occurs throughout our bodies. Why have we been so slow to consider and study it in the brain?

For those who haven't checked out the Endothelial Health program--which stresses diet, nutrition, lifestyle and exercise to enhance and maintain NO--got to www.ccsvi.org under "helping myself."
cheer

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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Here is another paper out of Austria last week, with related research:
Experimental Gerontology Review-

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

All of this new research into endothelial and cerebrovascular dysfuntion is so exciting. It seems that we are on the cusp of understanding a lot more about various disease processes. Encouraging! Thanks for posting these links TMrox and cheer!