Chronic Mild Cerebrovascular Dysfunction as a cause of Alzheimer's Disease
Dr. Christian Humpel
Alzheimer’s disease (AD) is a progressive chronic disorder and is characterized by -amyloid plaques and angiopathy, tau pathology, neuronal cell death, and inflammatory responses. The reasons for this disease are not known. This review proposes the hypothesis that a chronic mild long lasting cerebrovascular dysfunction could initiate a cascade of events.
The role of NGF on the cell death of cholinergic neurons is discussed. Additional risk factors (e.g. acidosis, metals) contribute to plaque development. Key words: vascular system, Alzheimer, vascular dementia, hypothesis, cascade leading to AD.
It is suggested that (vascular) risk factors (e.g. hypercholesterolemia, type 2 diabetes, hyperhomocysteinemaia) causes either damage of the cerebrovascular system including silent strokes or causes dysregulation of beta-amyloid clearance at the blood-brain barrier resulting in increased brain beta-amyloid. A cascade of subsequent downstream events may lead to disturbed metabolic changes, and neuroinflammation and tau pathology.
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