Mayo clinic: Aspirin for MS-Related Fatigue -clinical trial

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Mayo clinic: Aspirin for MS-Related Fatigue -clinical trial

Postby malden » Fri Dec 03, 2010 10:33 am

http://www.mayoclinic.org/medicalprofs/ ... tigue.html

Interested for me and my theory about why ccsvi tratment first results are less fatique... etc. I got it all by my own aspirin therapy.
Last edited by malden on Fri Dec 03, 2010 1:22 pm, edited 1 time in total.
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Postby TMrox » Fri Dec 03, 2010 11:01 am

Interesting. One of my doctors (who is not a neuro) is very skeptic of the CCSVI theory. He wanted to show me that I improved after my angio because of the blood thinners and not because of the destenosis.

To show me he was right he tested me for everysingle blood clotting disorders on earth and ordered more angio scans. He ordered these test about two monts after I stopped taking the blood thinners.

Then this doc sent me a massive bill (which my insurance refused to pay) saying sorry all your blood/angio tests came back normal. I still think CCSVI is pretty much nonsense and what you are experincing is a placebo effect.

I'm embracing the placebo then :)
Diagnosed with Transverse Myelitis in December 2008. Inflammatory demyelination of the spinal cord (c3-c5). No MS, but still CCSVI.
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Postby malden » Fri Dec 03, 2010 11:09 am

TMrox wrote:Interesting. One of my doctors (who is not a neuro) is very skeptic of the CCSVI theory. He wanted to show me that I improved after my angio because of the blood thinners and not because of the destenosis.

To show me he was right he tested me for everysingle blood clotting disorders on earth and ordered more angio scans. He ordered these test about two monts after I stopped taking the blood thinners.

Then this doc sent me a massive bill (which my insurance refused to pay) saying sorry all your blood/angio tests came back normal. I still think CCSVI is pretty much nonsense and what you are experincing is a placebo effect.

I'm embracing the placebo then :)


I read carefully, but can't see what is result (conclusion) of your doctor's analyses? M.
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Postby Cece » Fri Dec 03, 2010 11:14 am

Malden wrote:
TMrox wrote:Interesting. One of my doctors (who is not a neuro) is very skeptic of the CCSVI theory. He wanted to show me that I improved after my angio because of the blood thinners and not because of the destenosis.

To show me he was right he tested me for everysingle blood clotting disorders on earth and ordered more angio scans. He ordered these test about two monts after I stopped taking the blood thinners.

Then this doc sent me a massive bill (which my insurance refused to pay) saying sorry all your blood/angio tests came back normal. I still think CCSVI is pretty much nonsense and what you are experincing is a placebo effect.

I'm embracing the placebo then :)

bolded it for you, M.
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Postby CCSVIhusband » Fri Dec 03, 2010 11:43 am

but make sure you point out that he had the CCSVI treatment before it came back normal ...
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Postby cheerleader » Fri Dec 03, 2010 11:56 am

aspirin is not just about platelets/coagulation.
It also addresses endothelial dysfunction in oxidative stress and increases nitric oxide availability.
http://ajpheart.physiology.org/cgi/cont ... 94/4/H1562

Aspirin preserves the integrity of the vascular wall through its free radical scavenging properties and its capacity to protect endothelial cells from the deleterious effects of hydrogen peroxide (16, 21, 40). The effects of aspirin in preventing cardiovascular events are attributed to its platelet-inhibitory function, which results from the irreversible inhibition of the activity of platelet cyclooxygenase and thromboxane B2, the major products of cyclooxygenase (COX-1) activity (39). Low-dose aspirin suppresses the age-related increase in oxidative stress via the modulation of NF-B (27). The acetyl group provides aspirin with the capacity to increase endothelial nitric oxide (NO) synthesis and bioavailability (14, 15, 24, 46, 53). Aspirin reduces monocyte chemoattractant protein-1 and soluble ICAM-1 levels in low-density lipoprotein (LDL) receptor-deficient mice (8, 9). This reduction in adherence molecule expression has a functional effect, since aspirin inhibits monocyte adhesion to LDL-stimulated endothelial cells (15). Evidence from explorative clinical trials suggests that treatment with low-dose aspirin increases EDR. In humans, low-dose aspirin administered over a 2-mo period has been found to improve endothelial function (34). In rats with vascular endothelial injury induced by an injection of native LDL, low-dose aspirin is able to reverse the EDR dysfunction (11).

http://ajpheart.physiology.org/cgi/cont ... 94/4/H1562

Aspirin and the entire endothelial health program were not enough for Jeff to overcome his fatigue. He had such severe stenosis, he would fall asleep driving and had to stop after a fender bender.
Since angioplasty, he is awake full days, no naps, and back to working and driving. For some, aspirin can only do so much.
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dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby malden » Fri Dec 03, 2010 12:00 pm

Cece wrote:
Malden wrote:
TMrox wrote:Interesting. One of my doctors (who is not a neuro) is very skeptic of the CCSVI theory. He wanted to show me that I improved after my angio because of the blood thinners and not because of the destenosis.

To show me he was right he tested me for everysingle blood clotting disorders on earth and ordered more angio scans. He ordered these test about two monts after I stopped taking the blood thinners.

Then this doc sent me a massive bill (which my insurance refused to pay) saying sorry all your blood/angio tests came back normal. I still think CCSVI is pretty much nonsense and what you are experincing is a placebo effect.

I'm embracing the placebo then :)

I read carefully, but can't see what is result (conclusion) of your doctor's analyses? M.

bolded it for you, M.

...come back normal...?!
When?
"He ordered these test about two monts after I stopped taking the blood thinners..."

But if he was RRMS then it's normal that after relapse you go to remision. All RRMS patients do. So, relaps was gone (thanks to aspirins, blood thinners) two monts after. Whats strange in this?
Last edited by malden on Fri Dec 03, 2010 12:48 pm, edited 2 times in total.
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Postby bluesky63 » Fri Dec 03, 2010 12:07 pm

http://hubpages.com/hub/Blood-Clot-Trea ... d-Thinners

I just found this but I don't have time to read it. I want to when I have a chance later on -- it looks like a good resource!
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Postby eve » Fri Dec 03, 2010 12:14 pm

I take 100 mg of aspirin daily (not liberated) and it def. improves my fatigue. I had to quit a while back as my neuro was willing to run some bloodclotting tests also (he is supportive) and it came back full force. I had forgotten how bad it was.
Very interested in this study.
dx 2002,RRMS,  suspected begin of MS 1978 (age 10)
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Postby TMrox » Fri Dec 03, 2010 12:22 pm

Malden, I don't have MS.I have a cousing disease with known risk to evolve to MS called Transverse Myelitis. In TM typicaly there are no relaspes, and if they ocurr then it is likely that the condition has evolved to MS.

I was not having a relapse when this doc tested me. What this doc was trying to do in my case was to find blood clotting disorders such as antiphospholipid syndrom, thrombofilia, known in the literature to cause TM. He also tested for other autoiummune conditions commonly associated to clotting disorders (e.g. lupus) and tried to look for evidence of some blood clots in lungs or elsewhere.

All my tests came back negative/normal. Meaning I have none of these blood clotting disorders.

So this doc thinks I'm greatly enjoying a placebo effect.
Last edited by TMrox on Fri Dec 03, 2010 2:24 pm, edited 2 times in total.
Diagnosed with Transverse Myelitis in December 2008. Inflammatory demyelination of the spinal cord (c3-c5). No MS, but still CCSVI.
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Postby malden » Fri Dec 03, 2010 12:53 pm

eve wrote:I take 100 mg of aspirin daily (not liberated) and it def. improves my fatigue. I had to quit a while back as my neuro was willing to run some bloodclotting tests also (he is supportive) and it came back full force. I had forgotten how bad it was.
Very interested in this study.

http://www.thisisms.com/ftopicp-116247.html#116247

... last month I started with Aspirin 500 mg 2x per day, 5 days, then reduce it to 1 per day, 10 days, and now I am on 200 mg per day.

Suprisingly, I feel better (less morning fatigue, less sluggishness, able to focus on work, more stable on legs, less stagering...)

Btw, I didnt take any medications before this Aspirin cure.


Best regards,

M.
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