I found this in one of Zamboni's paper
"Although investigations into the role of iron in MS are still few, many high-resolution MR techniques have shown stored iron regions inside the brain and spinal cord
Blocked extracranial venous blood outflow causes a high rate of cerebral venous reflux in MS patients, as shown in earlier studies (Zamboni et al, 2007, 2009a, 2009b, 2009c). This detected reflux, propagated from the chest and neck veins into the parenchymal veins of the brain, may have an important function in explaining the mechanism of iron overload in MS
Autoimmune cells mainly destroy oligodendrocytes, the cells responsible for creating and maintaining a fatty layer known as the myelin sheath, which helps the neurons to carry action potentials across axonal pole. In MS, this myelin sheath becomes thin or completely disappears. Most importantly, due to the repeated attacks of autoimmune cells, the remyelination capacity of the insulating sheath is lost, leading to scar-like plaques or lesions situated around the damaged axons (Chari, 2007). However, in such a scenario, iron overload and oxidative stress may be the underlying cause that leads to immunomodulation in chronic MS
Diagnosed with Transverse Myelitis in December 2008. Inflammatory demyelination of the spinal cord (c3-c5). No MS, but still CCSVI.