This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Thu May 23, 2013 2:53 pm

View unanswered posts | View active topics


Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]



Post new topic Reply to topic  Page 1 of 1
  [ 3 posts ] 
  Print view Previous topic | Next topic 
Author Message
Cece
PostPosted: Wed Dec 08, 2010 5:41 pm 
Offline
Family Elder

Joined: Mon Jan 04, 2010 4:00 pm
Posts: 8508
http://chestjournal.chestpubs.org/conte ... /287S.full

Quote:
In five randomized trials in patients with atrial fibrillation, the annual incidence of major bleeding averaged 1.3% in patients randomly assigned to warfarin therapy (targeted INR generally 2.0 to 3.0), compared with 1.0% in patients randomly assigned to treatment with placebo.

Quote:
In a case-control study, the risk of intracerebral hemorrhage doubled for each increase of approximately 1 in the INR.

Quote:
Concomitant use of aspirin has been associated with a higher frequency of bleeding, even in patients treated with warfarin therapy with a mean INR of 1.5. In a large randomized trial comparing the combination of low-dose warfarin therapy and aspirin, 80 mg/d, to aspirin, 160 mg/d, in patients with a history of myocardial infarction, the frequency of spontaneous major hemorrhage during the first year of therapy was increased to 1.4% in patients treated with 3 mg of warfarin (INR < 2.0) and aspirin, 80 mg/d, compared with 0.7% in patients treated with aspirin, 160 mg/d (p = 0.01).

No one is getting put on Coumadin as a first drug after treatment but only occasionally when a patient has clotted they are sometimes put on Coumadin to prevent the clot getting worse. But if we find out the other ones (Clexane, Arixtra, Plavix) then we can see where they rank against Coumadin.

We went through a time period when all the docs seemed to be prescribing Plavix or aspirin only and now we are seeing more of the stronger anticoagulants or combined therapy from some of the docs. Like everything else when looking at anticoagulation, the doctors weighs the risks vs the benefits. If we subtract out the placebo from the Coumadin, the risk would seem to be 0.3%. Small but real. :(

This is a sensitive topic but I wanted to address it so that we're not fighting fears but looking at real facts, neither inflated nor minimized.
Top
 Profile  
 
HappyPoet
 Post subject:
PostPosted: Thu Dec 09, 2010 12:08 pm 
Offline
Family Elder
User avatar

Joined: Thu Jul 09, 2009 3:00 pm
Posts: 1274
Cece wrote:
This is a sensitive topic but I wanted to address it so that we're not fighting fears but looking at real facts, neither inflated nor minimized.

Well said. Thank you for all the research.
Top
 Profile  
 
malden
 Post subject:
PostPosted: Thu Dec 09, 2010 1:50 pm 
Cece wrote:
http://www.thisisms.com/ftopicp-145274.html#145274
...
One death over a year ago caused by a cerebral hemorrhage that, once begun, was made worse by the multiple prescribed blood thinners.

One death as an apparent combined result of clotting in the stent, lack of prompt treatment, and thrombolysis which is not a blood thinner but directly dissolves clots but with a complication risk of internal bleeding.
...
Cece wrote:
Like everything else when looking at anticoagulation, the doctors weighs the risks vs the benefits. If we subtract out the placebo from the Coumadin, the risk would seem to be 0.3%. Small but real.

Does those two deaths fits in this "0.3% small but real" risk? What numbers can express those two deaths?
Top
  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  Page 1 of 1
  [ 3 posts ] 

Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]

Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. Coumadin and LDN ?

questor

11

1557

Sun Nov 08, 2009 10:11 am

SammyJo View the latest post

There are no new unread posts for this topic. worried the most about coumadin . . .

bluesky63

8

1315

Fri Nov 13, 2009 8:45 am

ErikaSlovakia View the latest post

There are no new unread posts for this topic. Coumadin vs Clexane

Sesj

5

1661

Fri Nov 13, 2009 1:51 am

ErikaSlovakia View the latest post

There are no new unread posts for this topic. Blood Clot and Coumadin

Bizzy

8

1312

Mon Mar 07, 2011 7:35 pm

1eye View the latest post

There are no new unread posts for this topic. PT/INR resource, info, interactions with coumadin, etc.

CureIous

0

776

Thu Sep 24, 2009 6:14 pm

CureIous View the latest post

 


Who is online

Users browsing this forum: No registered users

You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to: