This is very interesting.....
"Two promising technologies include drug-coated balloons and cryo-plasty, both of which offer a fresh view on plain old balloon angioplasty. These systems put most of their emphasis on nonstent treatments for peripheral artery disease (PAD) below the knee where stents cannot be used. But, the technologies may also offer an alternative to the comorbidities of implanting stents, and in treating in-stent restenosis."
"...an alternative to drugs that is already on the U.S. market is cryoplasty – using balloons cooled below freezing to lessen vessel trauma."