Antihistamines and the BBB

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Antihistamines and the BBB

Postby Rokkit » Thu Jan 06, 2011 3:15 pm

I have seasonal nasal allergies. Antihistamines make me drowsy, even the ones that aren't supposed to like allegra, claritan and zyrtec. I took a zyrtec yesterday and it knocked me out for 12 hours.

The reason these aren't supposed to make you drowsy is that they don't cross the blood brain barrier, or least not that much. So, I've been wondering if my immune system can attack my CNS for the same reason these antihistamines make me drowsy: CCSVI opened up my BBB.

If there's anything to this, then I should be able to tell if anything I do is helping heal my BBB over time by taking a zyrtec. :D

Nothing's ever this simple of course, but I thought it worth mentioning here. Does anyone else have this issue with the "non-drowsy" antihistamines?
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Postby David1949 » Thu Jan 06, 2011 3:55 pm

As I understand, it the BBB is made up of tightly knit endothelial cells lining the capillaries in the brain. To my knowledge the caplillaries are not affected by CCSVI treatment. But I'm not a doctor so maybe that would be a better question for Dr. Sclafani.
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Postby frodo » Thu Jan 06, 2011 4:49 pm

David1949 wrote:As I understand, it the BBB is made up of tightly knit endothelial cells lining the capillaries in the brain. To my knowledge the caplillaries are not affected by CCSVI treatment. But I'm not a doctor so maybe that would be a better question for Dr. Sclafani.


The BBB is malfunctioning for sure in MS patients. There is enough evidence to consider that a fact. In the CCSVI model of MS, it is hypothesized that it is the lack of proper blood flow what creates these BBB problems.

From this point of view I find quite interesting the effects that Rokkit has reported. It would be nice to know if some other people has noticed something similar. It could be used to monitor the healing of the BBB after angioplasty if the model is correct.

Maybe Dr. Sclafani can give us a broader view. Don't you think it would be worthy to post this thoughts in his thread?
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