cheerleader wrote:marcstck wrote:
Instead, it was found that the severity of vascular abnormality increased with the severity of disease progression, indicating that either worsening stenosis created worsening disease, or worsening disease created worsening stenosis. Congenital abnormalities wouldn't be expected to behave in such a manner.
The congenital model of CCSVI states that over the course of decades, vascular abnormalities present at the time of birth lead to an ever increasing amount of central nervous system damage, which remains subclinical for several decades until becoming symptomatic and consequently diagnosed as MS. Such abnormalities would not be expected to worsen with disease progression, as they'd be genetically hardwired into the anatomy.
Marc,
I love you....but you are wrong about this, and it's confusing people. Cece's right. I've referred to the BB Lee paper over a dozen times on this site. PLEASE read it. Truncular venous malformations are present at birth and worsen as the body ages. They grow as the body grows and have a growth spurt at puberty. DISTURBED BLOOD FLOW makes them worse. ENDOTHELIAL DYSFUNCTION makes them worse. This happens with age. Dr. Lee likens CCSVI to BUDD CHIARI disease, where the damage to the liver doesn't show up until the third or fourth decade even though the malformation is CONGENITAL. And the liver disease progresses with age, until the liver fails. Further studies need to be done....but IT MAKES SENSE to Dr. B.B. Lee, Dr. Laredo, Dr. Neville and the venous experts at Georgetown University.
CCSVI and venous malformations will get worse as the body ages and MS progresses.
HERE IS THE PAPER again. Sorry to yell, but we have to be careful about making medical pronouncements WITHOUT linking to RESEARCH. I've discussed this with the doctors, listened to them speak at conferences....I don't make stuff up or write bold pronouncements. I am not an "expert." I just collect information and put it online. If you find RESEARCH that refutes this, please post it.
http://www.fondazionehilarescere.org/pd ... 8-ANGY.pdf
cheer
Joan, I love you too, and I'm not being facetious about that. But to accuse me of making statements without medical backup is just plain wrong. I referred people back the my original post on WK, which links to the many abstracts at ECTRIMS that dispute CCSVI as a cause of MS. It also links to several that contradict this finding.
You refer time and time again to the same pieces of research, all conducted by a limited number of physicians, most of whom fall under Zamboni's umbrella. I have read the Lee paper, and believe it has merit, but it represents the opinions of one group. You have a large emotional investment in CCSVI, which I completely understand, but it seems clear that you tend to denigrate any research that contradicts your beliefs and venerate research findings that supports them. Given the weight of your influence among the CCSVI community, accusing me of confusing the issue is a bit of the pot calling the kettle black.
You're not the only one who has spoken to a variety of well-respected doctors about these issues. I've done my due diligence as well, and stand by any statements I've made. I've consistently presented as balanced a view of the evolution of the CCSVI hypothesis as I possibly can, and have striven to not let emotion cloud perception. I'd love the hypothesis to prove absolutely correct, and completely revolutionize the perception and treatment of MS. I can't let that desire, though, cloud my take on the ever-expanding CCSVI knowledgebase.
As it now stands, nothing definitive can be said about CCSVI, and we can only go where the science leads us. In Dr. Zivadinov's case, the science is leading him away from believing that CCSVI is the cause of MS, as can be gleaned from the steady stream of research, and Dr. Z's conclusions of that research, coming out of BNAC.
As for links to research, here are a few. Their conclusions are open to debate, as are the conclusions of any scientific research, but to dismiss them outright is folly.
http://registration.akm.ch/einsicht.php ... KEN_ID=900
http://registration.akm.ch/einsicht.php ... KEN_ID=900
http://registration.akm.ch/einsicht.php ... KEN_ID=900