PATIENTS AND CAREGIVERS DISCUSS THE PHYSICIAN DISCUSSION

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Postby Algis » Sat Jan 29, 2011 7:51 am

what your thinking is here on Taxol


Taxol is a trademark of Paclitaxel. Originally, Paclitaxel is bark from a single Pacific yew tree, Taxus brevifolia.

Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.

(*) All above info stolen and unscrupulously copied from wikipedia at:
http://en.wikipedia.org/wiki/Taxol

(**) - Note - They talk about arteries, but there might be a hint/lead there?
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Postby NHE » Sat Jan 29, 2011 11:48 pm

Algis wrote:
what your thinking is here on Taxol


Taxol is a trademark of Paclitaxel. Originally, Paclitaxel is bark from a single Pacific yew tree, Taxus brevifolia.

Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.


Hi Algis,
Thanks for the clarification. It sounds like Taxol delivered locally, either by an eluting stent or by a coated balloon, might help with intimal hyperplasia, but I'm not sure if it would help for clots. Perhaps Taxol could be used soon after the stent was endothelialized to help prevent overgrowth, but still allow the stent to stay firmly anchored in the vein?

NHE
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Postby drsclafani » Sun Jan 30, 2011 1:03 am

Algis wrote:Sorry to intrude; but is Taxol ever used for clots?


no, TPA and/or mechanical devices are used
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Re: Whee do you start?

Postby drsclafani » Sun Jan 30, 2011 1:06 am

Rosegirl wrote:Hi, Dr. S.

Some studies report that about half of the treated patients have problems with valves. How many valves are there, and where are they located?

Would it make sense to test and treat valves before treating problems in other areas? For example, if opening a stuck valve makes all the collateral veins above it go away, that would minimize any trauma that might otherwise have occurred if the doctor systematically treated any problems found as they occurred.


bingo rosegirl!
you have been listening

obstruction results in collateral flow away from the obstructed vein. low flow causes low volume, low volume causes collapse of the normal vein.

one shouuld always go for the obstructions at the confluens first.
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Other valves?

Postby Rosegirl » Sun Jan 30, 2011 3:05 pm

It sounds like there is a valve between each internal jugular and the azygos. Is there a valve at the end of the azygos before it connects to the superior vena cava or whatever comes next?

Or is it more likely that the azygos has problems with stenoses, webs, etc., but not with a valve that prevents it from emptying into the next structure?
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