The first part of my previous post makes NOW no sense - since the references were removed ... so I'll get rid of it ... no problem - it wasn't anything personal, just responding to questions.
But I think the 2nd part (below) is an interesting tale especially at the bottom, and some relevant questions ...
Now ... whether CCSVI proves out or not, time will tell. From what I've seen with my own eyes, there's something to it for sure.
animal models, where veins in animals will be occluded and limit flow from the brain and spine ... if they develop "MS" symptoms, I'd imagine that will be pretty telling. (though I wonder how you ask a mouse, or cat, or dog, or monkey IF it's numb). (or how to spell WORLD backwards - as I read in another post this morning).
with further research into whether doppler or MRV are even valuable diagnostic tools considering so many IRs are finding on venogram CCSVI in ALL people with "MS" ... maybe it is completely unnecessary to even waste time with the doppler and MRV as they don't give a true picture of "in the veins". (remembering that viewing the vein (azygous) draining the spine is hard to image using either diagnostic method)
However what they do, do, is show that there is reflux and improper architecture. So for a diagnostic tool, it might not be bad ... (on my wife's first doppler - by an IR - she was found to have 1 of 5 criteria). The venogram showed something vastly different. On her 2nd doppler, it showed 3 of 5 criteria (a much more experienced doppler operator - who trained with the best in Canada). The 2nd venogram found problems in the areas of those criteria ... but was the doppler actually necessary?
Between you and I, Bob ..., I'd be more than happy to contribute to the science and have a doppler, MRV, or venogram ... to help prove "healthy" controls are different. (I don't know what angioplasty would do for me, considering I have NO "MS" symptoms - but I'd be willing to let them do one just to see what happened if they did so to my veins). But until they call for volunteers to do that, I doubt any doctor every would or could just to prove a point.
So the research is held back by previously held theories.
I'm sure part of it is the "business" of MS patients - for the drug companies ... who we know give money to neurologists for "research". Make no mistake, there is a BUSINESS of MS. Billions of dollars annually. And people who hold access to that kind of money - with no end in sight, and a limited but growing client list - won't let it go easily (would I? would you?). They know their drugs don't work, but continue to promise 'breakthroughs' are just around the corner (for decades now). And they keep this business going by ongoing studies, payments, shifting of drugs designed for one purpose into a different purpose (see Ampyra) ... make no mistake, "MS" is a business. - and until the status quo changes (be it CCSVI, or some other theory that proves out) business is GOOD. Neurologists aren't questioning the CRABs drugs, because it's ALL they have that has shown ANY benefit (no matter how small). And they can basically keep you on for 10 years (generally) until they change your diagnosis to SPMS - and even then still keep you on it.
Part of the problem is the scientific method. IF we're going to allow poorly designed and executed studies by neurologists to trump research by IRs and vascular doctors ... then "science" is flawed - just because neurologists "owned" "MS" in the past. Times change, and should change IF science dictates. There is obviously something to THOUSANDS of MS patients being found to have CCSVI at this point ... so I ask ... WHY do none of these studies on CCSVI by neurologists have vascular surgeons or IRs working with them. Who MIGHT see something different.
After years of practicing neurology ... are they really skilled in analyzing doppler results? (when was the last time you'd suspect they did use one)? I'm not accusing neurologists of being dumb nor ignorant ... I'm just saying, why don't they go sit through a venogram ... with an IR ... and see what's going on INSIDE the veins instead of a potentially useless diagnostic tool?
Interview the patient before the procedure. Do a neurological assessment. Watch the procedure, take whatever notes you want, ask whatever questions you want. THEN interview the patient, x hours after the procedure. x days after the procedure. x months after the procedure. And do neurological assessments again. Instead of dismissing it without ever seeing it from the patients point of view.
Again, "science" can be manipulated ... when you want it to be. And "science" can be held back.
What neurologists don't know ... is A LOT. Why aren't they willing to look at new theories?
I'll bet someday soon they do. Neurology is still going to be a big part of "MS" ... and CCSVI isn't going to be the answer for ALL I'm positive. After all, in a 1st MS attack someone may be completely devastated neurologically ... and need a neurologist to manage neurological symptoms. But WHEN CCSVI proves out ... they might just only need repeated ballooning (or stenting when stents are developed that work for life (continued implantation of dissolvable stents, or something we don't even imagine). I mean, 30 years ago who'd imagine you could read live what I write on a box sitting on my lap that weighs no more than 1 pound, that's not connected to a single wire. The world changes. Things develop. People learn. Information travels faster. The wave of CCSVI is still young ... the tsunami is building.
Just so we're all aware, I have presented CCSVI to a board of directors of big name companies (for a work "project" - in a debate/discussion of business operations - again see letting access to billions of dollars as a company go) ... where nobody knows anything about it, or much about MS ... as a way that science is flawed. Whether CCSVI pans out or not ...
Just the facts as we know them now ... each on the board agreed, as a company, they'd not want CCSVI to pan out - and would do what it took to anti-marketing attack it pre-emptively (even if that meant that CCSVI could be the "cure" to the disease).
Afterwards, you wouldn't believe how many people out of the hundred or so in the room came up to me and said ... "is this real"? "is this really happening"? "how sad" ...
The dream of any business model is to have unlimited access to a product and market segment that will always grow or remain stable. "MS" fits that description.
It is a HUGE, BLOATED cash-cow ... in a business that is also a rising star (in that profits will continue to rise - as we see that more and more worldwide are diagnosed with "MS" and go on these drugs).
Those fists are tightly gripped around that money ... it won't be easy to pry them away.