International Society for Neurovascular Disease (March 2011)

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Postby MrSuccess » Sun Mar 13, 2011 8:32 pm

Big fan of Dr. Hubbard here .... but ..... is Dr. Hubbard not a Neurologist ?

Neurosurgeon ?

Can someone verify this ...... as this is important .... as Dr. Hubbard seems puzzled at his fellow Neurologist's resistance in making an effort to understand CCSVI .



Mr. Success
User avatar
MrSuccess
Family Elder
 
Posts: 883
Joined: Fri Sep 18, 2009 3:00 pm

Advertisement

Postby CD » Sun Mar 13, 2011 9:44 pm

User avatar
CD
Family Elder
 
Posts: 217
Joined: Sun Dec 19, 2010 4:00 pm
Location: USA

italy

Postby zinamaria » Sun Mar 13, 2011 9:50 pm

Hey Sou, so you're there! I'm jealous...by the way, both Zamboni and Salvi speak good English, and they are both very personable, so don't shy away from talking with either one of them if you get the chance. Dr. Salvi is really special.

Of course you'll try the gelato?? Noce is my favorite.

A presto!
User avatar
zinamaria
Family Elder
 
Posts: 296
Joined: Fri Dec 04, 2009 4:00 pm

Postby MrSuccess » Sun Mar 13, 2011 10:43 pm

thanks CD - my information is correct .

nice job getting that link ....... this is a must see for everyone here
at TIMS. It's long ....... but worth listening to.....

and again ..... I propose Dr. Hubbard as the CCSVI spokesman. :idea:



Mr. Success
User avatar
MrSuccess
Family Elder
 
Posts: 883
Joined: Fri Sep 18, 2009 3:00 pm

Postby sou » Mon Mar 14, 2011 7:29 am

I am in the conference room. I am finding some time to write to the board because stroke related presentations are taking place. What I have felt so far is that the whole CCSVI theory is really in its infancy, but there is a widepread conviction that vascular issues preceed CNS damage.

There was a really interesting presentation from Dr. Zlokovic, regarding the mechanisms of neurodegeneration and a treatment in trials for many such diseases.

Is anybody other thisismser in the room (except Dr Sclafani whom I can see a few rows away)?

Dr Hubbard's presentation is coming within the hour.
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."
User avatar
sou
Family Elder
 
Posts: 582
Joined: Sat Dec 20, 2008 4:00 pm
Location: Greece

Postby cheerleader » Mon Mar 14, 2011 7:36 am

Great to hear from you, sou!!!
Here's the latest print story and video on Dr. Hubbard's study from CTV (updated)
http://www.ctv.ca/CTVNews/Health/201103 ... dy-110313/

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5015
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby Cece » Mon Mar 14, 2011 8:40 am

sou wrote:There was a really interesting presentation from Dr. Zlokovic, regarding the mechanisms of neurodegeneration and a treatment in trials for many such diseases.


Interesting! Here is a 2004 abstract from Dr. Zlokovic (if it is the same Dr. Zlokovic):
Neuron, Volume 57, Issue 2, 178-201, 24 January 2008

doi:10.1016/j.neuron.2008.01.003

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Berislav V. Zlokovic1, ,

1 Center for Neurodegenerative and Vascular Brain Disorders, Frank P. Smith Laboratory for Neuroscience and Neurosurgical Research, Department of Neurosurgery, University of Rochester Medical School, Rochester, NY 14642, USA

Summary
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the BBB separates components of the circulating blood from neurons. Moreover, the BBB maintains the chemical composition of the neuronal milieu, which is required for proper functioning of neuronal circuits, synaptic transmission, synaptic remodeling, angiogenesis, and neurogenesis in the adult brain. BBB breakdown, due to disruption of the tight junctions, altered transport of molecules between blood and brain and brain and blood, aberrant angiogenesis, vessel regression, brain hypoperfusion, and inflammatory responses, may initiate and/or contribute to a vicious circle of the disease process, resulting in progressive synaptic and neuronal dysfunction and loss in disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and others. These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the BBB and other nonneuronal cells of the neurovascular unit.

Dr. Zlokovic makes it easy! This information fits in well with CCSVI, since CCSVI would be the initiating cause of the disruption of the tight junctions of the endothelial blood-brain barrier.
Is anybody other thisismser in the room (except Dr Sclafani whom I can see a few rows away)?

Dr Hubbard's presentation is coming within the hour.

I wish I were in the room! Thank you, sou, can't wait to hear more. :)
Cece
Family Elder
 
Posts: 8990
Joined: Mon Jan 04, 2010 4:00 pm

Postby Rokkit » Mon Mar 14, 2011 8:53 am

Go, Sou, go!
Rokkit
Family Elder
 
Posts: 669
Joined: Tue May 19, 2009 3:00 pm

Postby cheerleader » Mon Mar 14, 2011 3:31 pm

Italian television reports on the conference in Bologna--you'll see some familiar faces


http://www.youtube.com/watch?v=I-CR0N7jg4Q
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5015
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby cheerleader » Mon Mar 14, 2011 4:30 pm

The first press release out of Bologna---CONSENSUS!
Forty seven international vascular specialists have outlined the criterea for establishing a CCSVI diagnosis. This also means that all previous studies which did not utilize this criteria are null and void according to the vascular doctors.


Press Release


ISNVD Annual Meeting
International Society for Neurovascular Disease,
at present highly committed to the study of CCSVI


Bologna, March 14-15, 2011

Report on the CONSENSUS CONFERENCE of March 13, 2011


90% OF THE ULTRASONOGRAPHY METHOD SUGGESTED BY PROF PAOLO ZAMBONI FOR THE DIAGNOSIS OF CCSVI WAS UNANIMOUSLY APPROVED.

A DOCUMENT SPECIFYING THE MOST IMPORTANT RESEARCH REFERENCE PARAMETERS WAS SIGNED BY THE MOST AUTHORATATIVE INTERNATIONAL FACULTY AND WILL BE APPLIED WORLD-WIDE.

A SERIES OF IMPROVEMENTS WERE ADDED TO INCREASE THE REPRODUCIBILITY AND THE DISSEMINATION OF THE METHOD.

As a prelude to the ISNVD (International Society for Neurovascular Disease) Annual Meeting, a Consensus Conference was held in Bologna on Sunday March 13th to define the practical guidelines to the screening investigation of CCSVI.

The Consensus Conference focused on the method proposed by Prof Zamboni for the detection of Chronic Cerebrospinal Venous Insufficiency (CCSVI) using Doppler. This diagnostic method was developed by Prof Paolo Zamboni and his Staff at the Center for Vascular Diseases of the Ferrara University.

The conference became necessary to standardize the investigation and reporting techniques all over the world. It will thus be possible to use common diagnostic criteria and standards in the scientific reports.

The Consensus Conference was attended by 40 experts from the International Society for Neurovascular Disease (ISNVD) and 7 representatives of the major national and international societies which are concerned with the diagnosis of the venous system by means of sonographic equipment.
The result was the unanimous approval of a document recognizing 90% of the method already proposed by the Ferrara and Bologna research teams.
Furthermore, a series of improvements were added to increase the reproducibility and the dissemination of the method.

Some parts of the method (the remaining 10%) are for the time being regarded as additional criteria requiring further investigation to obtain the necessary evidence.

The document signed in Bologna will be sent to the main journals in the following disciplines:
vascular diagnostics, radiology, neuroradiology, interventional radiology, vascular surgery, angiology, neurology, vascular diagnostics.

The medical community that participated in the conference was particularly satisfied with these results. This shared view will soon lead to new developments also at the level of the scientific publications which will be enriched by the experience gained in the numerous international centers which participated in the Consensus Conference.

The main societies that deal with the diagnostic investigation of the venous system and attended the Consensus Conference are: the European Venous Forum, the International uni0n of Phlebology, the International uni0n of Angiology, the American and Australasian College of Phlebology, the Italian Society of Vascular Pathology, and the Italian Society of Vascular and Endovascular Surgery.

Prof Zamboni’s co-chair was Prof Nicolaides who headed the vascular research team at St. Mary’s Hospital in London and had important roles as President of many vascular societies world-wide.
An important merit of Prof Nicolaides is that in 2000 he chaired the Consensus Conference which defined the way of investigating the venous system using ultrasonographic equipment.

Press Conference to discuss the results of the Meeting:
Tuesday, March 15 at 1:30 pm at CNR, Bologna (Meeting venue)

All press material is available on line on the following Website:
www.isnvdannualmeeting.org
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5015
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby Cece » Mon Mar 14, 2011 5:02 pm

This is great news again. Standardizing! Making sure an apple is an apple and not an orange before trying to compare the two! Our job here with the various studies that have come out would've been easier if the ultrasonography had been standardized.

Our vascular guys know what they are doing. :)
Can't wait for more.
Cece
Family Elder
 
Posts: 8990
Joined: Mon Jan 04, 2010 4:00 pm

Postby cheerleader » Mon Mar 14, 2011 6:27 pm

It is of note that the co-chair of this panel was Dr. Andrew Nicolaides, a distinguished expert in venous studies.

Here is hoping his expertise as a chief journal editor will expediate publication of studies in vascular journals.

Professor Nicolaides qualified at Guy’s Hospital Medical School, London University in 1962 and subsequently trained at Oxford, Kings College Hospital, London and has been Professor of Vascular Surgery at St Mary’s Hospital and Imperial College, London (1983-2000).

The Royal College of Surgeons (England) awarded him the ‘Jacksonian’ prize in 1972 for his pioneering work on the prevention of venous thromboembolism. His subsequent research has been focused on noninvasive diagnosis and screening using ultrasound, and stroke prevention.

He has received many awards from numerous scientific societies in recognition of his work on ultrasound and the prevention of stroke. A past president of the section of Measurement in Medicine of the Royal Society of Medicine and of the International uni0n of Angiology, he is Editor in Chief of International Angiology and is on the editorial boards of many vascular journals.

Professor Emeritus at Imperial College, an examiner for MS and PhD degrees for London University and Director of the Vascular Noninvasive Screening and Diagnostic Centre in London. He is also a “Special Scientist” at the University of Cyprus.

link to CV
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5015
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California

Postby Cece » Mon Mar 14, 2011 6:35 pm

An important merit of Prof Nicolaides is that in 2000 he chaired the Consensus Conference which defined the way of investigating the venous system using ultrasonographic equipment.

He knows his way around a consensus conference?
Thank you Cheer for bringing this information as it comes in!

I just saw that next year's ISNVD conference will be held in Orlando.
Cece
Family Elder
 
Posts: 8990
Joined: Mon Jan 04, 2010 4:00 pm

Postby MrSuccess » Mon Mar 14, 2011 10:31 pm

outstanding first day's work. We now have an agreed upon method to evaluate and test pwMS for CCSVI . This is significant.

Now any and all interested in exploring Dr. Zamboni's discovery -must follow established methods and no more freelancing .... and then questioning the results . Again , this is significant.

Best of all ..... these fine brilliant medical practitioners ..... no longer feel isolated in their work. They can look around the room and see dozens of respected colleagues ....... working towards the same goal .... understanding CCSVI and it's connection to MS.

Well done .

Can tomorrow get any better ? :)




Mr. Success
User avatar
MrSuccess
Family Elder
 
Posts: 883
Joined: Fri Sep 18, 2009 3:00 pm

Postby sou » Tue Mar 15, 2011 3:17 am

Hi.

I am in the conference room.

Dr Thanaporn's mouse model is still under development. The mice developed gait disturbances after 6 weeks of blocking their jugular veins, however the severity was significant but not disabling. The next step is trying to compare it or incorporate it to EAE. The funny part will be the testing of immune modulators on this new model to see what (or what doesn't) happens!

The most exciting presentation was that of Dr Beggs, regarding a hydrablic mechanical model of cerebral fluids, blood and CSF. I find the explanation of Dawson's fingers exciting, given that it comes out of "a toy" full of water! The model is still theoretical, but the maths and calculations are very accurate, so are its predictions.

Given Dr Zlokovic's discoveries proving that neurodegeneration can't but follow vascular abnormalitites and Dr Begg's model explaining how venous obstructions far away on the venous side can cause a deadly CSF oscilation throughout the CNS, along with hypoperfusion/oligaemia, I wonder who can still insist that normal people have occuded cerebral veins. Even if somebody have, they are not normal. The time bomb is there. The critics have to prove that thee is no threat to the neuronal health and that Zlokovic's vicious cycle has not been activated.

I 'll be back later. Hopefully...
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."
User avatar
sou
Family Elder
 
Posts: 582
Joined: Sat Dec 20, 2008 4:00 pm
Location: Greece

PreviousNext

Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users