This Is MS Multiple Sclerosis Community: Knowledge & Support

nice job explaining that CeCe.

once again ..... Professor Zamboni has provided the world with a jaw-dropping revelation....

I also tip my hat to the inventors of such medical devices ..... without them ....where would we be ?

let's see if I understand this correctly ..... so we have two people laying side by side .... each harnessed to a chair ..... a device shaped like a collar ..... is fixed to their necks ...... these neck collars are able to measure blood flow..... BOTH people show good blood flow .... more or less the same ..... then ..... the chairs are slowly risen until the two people are now sitting up ...... now blood flow is vastly different in the two people. One has no change in blood flow ..... it is the same as when they were lying down ..... the other persons bloodflow is much reduced now that they are sitting upright ...... that person has been pre-test diagnosed as having MS.

This discovery is huge.


Bravo Professor Zamboni





Mr. Success

Wow, you are fast, Cece

Note the research on axonal asphyxial damage...looks like hypoperfusion!

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

I was 34 minutes slower than you and the Facebook site!

Asphyxial axonal injury sounds like the impact on the axons from the hypoxia. This is of particular interest to me. (With my severe bilateral jugular blockages, I had a lot of hypoxia going on.)


Zamboni and huge discovery - now there are words that go well together.

The only correction I'd say is that the neck collar device measures volume, not flow. I don't think we show good blood flow while lying down. (We don't show good blood flow in any position.) I don't know if the supine volume of the MS patient's neck is the same as a healthy patient's.

The measureable difference is when the patient is aggressively sat up. (Not slowly but aggressively.) The healthy patient has a near-immediate decrease in the volume of their neck, as the congestion is swept away, the jugular size decreases, all is well. The MS patient has a very slow decrease, which indicates outflow obstructions, as the volume of blood flow is having a hard time clearing. It is amazing that these things are measureable.

This reminds me of the Zamboni protocol ultrasound, when they are measuring if there is a decrease in the size of the jugulars sitting as compared to lying down. If there is a decrease upon sitting up, that is normal and healthy. If there is no decrease or an increase, that is one of the five criteria that is needed for a CCSVI diagnosis done by doppler sonography.

Hope this helps! I am still working this out myself, I may have some of it wrong.

i'm just trying to generalize .... to explain a rough outline .... Dr. Zamboni hasn't given me specifics yet

I can hear the wheels spinning in the naysayers [ Neurologists ] ...... heads .... this will be another procedure they can arrange to have '' muffed up '' ...... and thus refute this wonderful diagnosis tool.

and yes CeCe .... I understand Flow and Pressure .... very well.

It is usually an either / or situation ........


what a great day for CCSVI ...... can tomorrow get even better ?





Mr. Success

I understand flow, I still struggle with pressure.

I think we have many better tomorrows ahead of us.

ISNVD has been full of the good stuff. There may be some more at SIR in two weeks? Not sure if it can begin to compare.

I looked to see if Dr. Trapp had written about hypoxia and neurons before:


http://tinyurl.com/4maxxeq

He's using a different explanation to come up with why the axons would have lowered oxygen levels, but everything from that point fits with CCSVI and axonal asphyxia and what consequence hypoxia has on the axons.

Dr. Trapp is another of the neurologists who presented at ISNVD, that is what set this conference apart from ISET and upcoming SIR, as those are all just for the vascular guys and this one succeeded in its mission to be both neuro and vascular.

Another neurologist who was keynote speaker at ISNVD was Dr. Berislov Zlokovic of the University of Rochester who spoke on the connection of the endothelium, BBB, vasculature, and neurodegeneration. I first contacted Dr. Zlokovic in 2008, when I was sending out my endothelial paper to different universities. I had included some of Dr. Zlokovic's research in the original endothelial health paper. Jeff and I are alumni from the University of Rochester's Eastman School of Music, and I was hoping to get a meeting with Dr. Zlokovic when we were in town for masterclasses....but we were never able to meet. And now, to see him speaking at the CCSVI conference in Bologna was incredibly gratifying.

Here are Dr. Zlokovic's CV and publications:
http://www.urmc.rochester.edu/people/?u ... esearchers

An interesting aside, Dr. Zlokovic dedicated his research to neurodegeneration after a dear friend developed ALS....he is a very well-respected researcher.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Wow, my head is spinning (that's while sitting upright! oh oh, better watch flow!!), but really this is so astonishing, and although I am connecting the dots, you sure help me out cece and cheer!

Sou, you're like our private detective, getting it all as it's happening, again molto grazie!

Just posted on the plethysmography collar on Facebook (wow! What an incredible use of current technology by Dr. Zamboni!) and realized it was probably the Doepp study that pointed him in this direction. Remember how they found increased blood volume in pwMS in the upright position!! Voila! The collar shows the difference between normals and pwCCSVI/MS....slowed venous drainage thru the extracranial veins. Brilliant.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

I don't think they spelled '' dope'' right.




Mr. Success

Is this the study that was just published or is it a different one? I didn't know there was anything about the "asphyxial cell phenomenon" in there. Very interested in this.

I am encouraged by everything coming out of ISNVD. So many different directions that are being explored. Our researchers have been busy and I think we'll be keeping them busy for the foreseeable future as well.

Thanks everyone for all the new info. Brilliant!

What he said at ISNVD is almost identical to this previous work:

So much information coming out now! here is Arlene Hubbard on Facebook:
http://www.facebook.com/notes/arlene-pe ... 6662914970

(much more through the link)

Novel pharmaceuticals that will target inflammation and endothelial pathology! I like some pharma, like the Arixtra and aspirin and nuvigil. Perhaps there will be something for us. I like the description of the triad (neurological, inflammatory & vascular) as the perfect storm. That feels about right.

Are these the collagen differences? Dr. Zamboni had some very interesting slides on this at ISET.

Simple! Or at least, simple to an engineer.

There are just so many presentations, so many ideas, so much ground-breaking.


There's the argument in favor of MRV.

Catheter venogram as a tarnished gold standard? MRV is better? Abnormal flow amplitude and phase: are these in the haacke protocol or is this new?

Flow not anatomy is the key. But the anatomy is what can be treated directly, then resulting in changes in the flow. Much to think about here. It has definitely been a candy store, a feast, more than I expected.