So much information coming out now! here is Arlene Hubbard on Facebook:
http://www.facebook.com/notes/arlene-pe ... 6662914970
Neurovascular Mechanisms in Neurodegenerative Diseases-B Zlokovic
Dr Zlokovic was the keynote speaker and is a world renowned scientist and (opera singer!).He described the triad of .: Neuro,inflammatory, and vascular...the perfect storm. He suggested that new pharmaceuticals would address the vascular component. He reviewed the literature showing abnormal perfusion, damaged endothelium including micro hemorrhage, periocyte loss in humans and animals. He is studying novel pharmaceuticals that will target inflammation and endothelial pathology.
(much more through the link)
Novel pharmaceuticals that will target inflammation and endothelial pathology! I like some pharma, like the Arixtra and aspirin and nuvigil. Perhaps there will be something for us. I like the description of the triad (neurological, inflammatory & vascular) as the perfect storm. That feels about right.
The pathology of the extracranial venous wall in MS- G Gabbiani
He showed abnormalities in the vein wall in MS which could not be explained by traditional atherosclerotic disease.
Are these the collagen differences? Dr. Zamboni had some very interesting slides on this at ISET.
Plethysmography and multiple sclerosis: analysis of novel data-S.J. Shepherd
Dr Shepherd, an engineer showed that neck venous flow could be modeled with simple mathmatical algorithms.
Simple! Or at least, simple to an engineer.
There are just so many presentations, so many ideas, so much ground-breaking.
MRI in treatment planning- M Haacke
Dr Haacke, the acknowledged expert in MR explained the superiority of MR. MR is the gold standard for describing MS lesions, it's the only technology that describes iron accumulation,it's the only technology that visualizes small veins, and it's the only technology that describes and objectively quantifies venous flow independent of operator expertise, which allows objective pre and post treatment comparison.
There's the argument in favor of MRV.
4D Magnetic Resonance Velocity Measurements in the Internal Jugular veins-CJ Elkins
Dr Dake presented for Dr Elkins. Catheter venography is a"tarnished" gold standard. CNS venous flow,not anatomy ,is the key to pathophysiology. New MR venous flow techniques show abnormal flow amplitude and phase in MS patients. New MRV technique provides detailed information on venous flow.
Catheter venogram as a tarnished gold standard? MRV is better? Abnormal flow amplitude and phase: are these in the haacke protocol or is this new?
Flow not anatomy is the key. But the anatomy is what can be treated directly, then resulting in changes in the flow. Much to think about here. It has definitely been a candy store, a feast, more than I expected.