International Society for Neurovascular Disease (March 2011)

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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International Society for Neurovascular Disease (March 2011)

Post by pairOdime »

http://www.isnvd.org/2010/11/annual-meeting-italy/

Ferrara, March 13, 2011 Italy
Vascular Diseases Center University of Ferrara – corso Giovecca 203

Bologna, March 14-15, 2011 Italy
CNR National Research Council of Bologna – via Gobetti 101

Major topics covered:
• Ultrasound and MR imaging in treatment planning
• The role of iron in MS and neurodegenerative disease
• Perfusion deficits and hypoxia and possible relationships to CCSVI
• New evidence of CCSVI in animal models
• Related vascular problems: venous embriology, idiopathic intracranial hypertension, normotensive hydrocephalus, carotid surgery in stroke
• CCSVI treatment: procedure and neurological outcomes
• Genetic studies
• Plethysmography
• Flow dynamics: modeling the cerebral venous system

Growing List of Speakers:
B. Zlokovic (USA)
M. Haacke (USA)
P. Zamboni (Italy)
B. Trapp (USA)
R. Zivadinov (USA)
R. Galeotti (Italy)
G. Gabbiani (Switzerland)
R. De Simone (Italy)
AH Siddiqui (USA)
C. Beggs (UK)
S. Shepherd (UK)
C. Franceschi (France)
A. Ferlini (Italy)
V. Iaccarino (Italy)
F. Florio (Italy)
C. Iadecola (USA)
F. Orzi (Italy)
G. De Simone (Italy)
C. Setacci (Italy)
R. Neville (USA)
A. Stella (Italy)
JB Ricco (France)
GM Biasi (Italy)
F. Mascoli (Italy)
G. Mansueto (Italy)
A. Nicolaides (Greece)
MB Griffin (UK)
D. Neuhardt (USA)
O. Maleti (Italy)
M De Marin (Croatia)
It's a paradigm shift
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cheerleader
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Post by cheerleader »

Exciting to see the growing list of doctors. I won't be able to attend and take notes this time, due to work conflicts. It will so interesting to see the abstracts and information that has been gleened since September 2009 in Bologna. I'll try to make them available as soon as possible.

I'm thrilled to note that Dr. Gabbiani will be speaking again. He is a vascular professor at the University of Geneva, and has published hundreds of papers-- he studied jugular vein tissue in pwCCSVI and found a collagen shift in the entire vein, not just the area of stenosis. A morphological change which has been connected to artheriosclerosis in arteries, not seen in veins before. Also a repeat visit from Dr. Franceschi, the pre-eminent vascular specialist of France. Dr. Ferlini is the Italian DNA specialist, and she has been looking at the connection in copy number variations in vascular malformations and MS.

And many new doctors, with representation from the UK, and more new names from the US and Italy. These are not Zamboni cronies. These are highly respected researchers. And they are all gathering to make sense out of venous abnomalities found in pwMS.
Very exciting times,
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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ikulo
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Post by ikulo »

These kinds of posts make me excited and hopeful for solid research in the near future. Thanks!
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ISNVD programme

Post by Cece »

Scientific programme


// ISNVD Annual Meeting

FERRARA, MARCH 13, 2011 ITALY
Aula Magna, Dipartimento di Scienze Giuridiche
BOLOGNA, MARCH 14-15, 2011 ITALY
CNR National Research Council of Bologna
ECM certificates


// 13 March

Ferrara, Dipartimento di Scienze Giuridiche - Aula Magna,
Corso Ercole I d'Este 47


// 8.30 > 16.30 // ISNVD Consensus Conference
In cooperation with UIA, EVF, UIP, ACP, AAsCP, SICVE, SIAPAV
US Screening for CCSVI. Recommendations for a protocol

EDITORIAL COMMITTEE
CHAIRMAN A. N. Nicolaides Cyprus
CO-CHAIRMAN P. Zamboni Italy (ISNVD representative)
SECRETARY S. Morovic Croatia, E. Menegatti Italy, G. Viselner Italy
FACULTY D. Neuhardt USA (ACP representative), M.B. Griffin UK (EVF representative), A. Cavezzi Italy (UIP representative), B.B. Lee USA (UIA representative), P. Thibault Australia (AAsCP), C. Setacci Italy (SICVE representative), G. Andreozzi Italy (SIAPAV representative), R. Zivadinov USA, K. Marr USA, S. Bastianello Italy (Editor Functional Neurology), S. Sclafani USA, M. Simka Poland, M. Al-Omari Jordan, C. Franceschi France, C.B. Beggs UK, S. Shepperd UK, M. Mancini Italy, P. Cecconi Italy, S. Mc Donald Canada, A. Lagace Canada, A. Stella Italy, A. Scuderi Brasile, V. DeMarin Croatia, O. Maleti Italy, M. Lugli Italy, F. Vic UK, N. Liasis Greece, M. Marinoni Italy, A. Galassi Italy



// 14 March
Bologna, CNR National Research Council,
Via Gobetti 101


8.30 > 9.00 // Congress Opening


9.00 PLENARY SESSION 1
CCSVI Imaging
MODERATORS E. M. Haacke USA, M. Salvatore Italy

9.00 > 9.15 Ultrasounds: data review
S. Bastianello Italy

9.15 > 9.30 Ultrasonographic transit time
M. Mancini Italy

9.30 > 9.45 Intravascular Ultrasounds
S. Sclafani USA

9.45 > 10.00 CT angiography
V. Iaccarino Italy

10.00 > 10.15 Fusion imaging technology
P. Zamboni Italy

10.15 > 10.30 Catheter Venography
R. Galeotti Italy

10.30 > 10.45 The limits of MRV
R. Zivadinov USA



11.15 > 11.30 Coffee Break



11.30 > 12.15
KEYNOTE LECTURE
PRESIDENT P. Zamboni Italy

Neurovascular Mechanisms in Neurodegenerative Diseases
B. Zlokovic USA



12.30 > 13.30 Lunch



13.30 PLENARY SESSION 2
Iron in Neurodegenerative Disorders
MODERATORS R. Zivadinov USA, M. Simka Poland

13.30 > 13.45 Iron and oxidative stress in AD
C. Iadecola USA

13.45 > 14.00 Iron and veins in MS
R. Zivadinov USA

14.00 > 14.15 Mitochondria dysfunction and differentiation of oligodendrocytes.
Is iron a candidate factor? - P. Pinton Italy

14.15 > 14.30 Iron traffic genetic variants in MS
D. Gemmati Italy



14.45 PLENARY SESSION 3
Update on Carotid Surgery and Stroke
In cooperation with the Italian Society for Vascular and Endovascular Surgery (SICVE)

MODERATORS C. Setacci Italy, A. N. Siddiqui USA

14.45 > 15.00 Carotid plaque echolucency and risk of stroke
in carotid stenting - G.M. Biasi Italy

15.00 > 15.15 Serological and morphological markers
of vulnerable carotid plaque - A. Stella Italy

15.15 > 15.30 Open Carotid Surgery in Emergency:
Indication and Technique - F. Mascoli Italy

15.30 > 15.45 Carotid artery angioplasty
and stenting following the CREST trial - A. N. Siddiqui USA



16.15 PLENARY SESSION 4
Best Abstracts Presentation - part 1
MODERATORS G Filippini Italy, R. Galeotti Italy

16.15 > 16.25 BOLD fMRI responses during cognitive tasks
in MS and effects of venoplasty - G. Buracas USA

16.25 > 16.35 A Prospective Analysis of Endovascular
Treatments of CCSVI in MS - M. Mehta USA

16.35 > 16.45 The Role of Three Dimensional Magnetic
Resonance Venography in Confirming of Color Doppler
Ultrasound Findings - N. Liasis Greece

16.45 > 16.55 Evaluating the presence of abnormal venous
vasculature in a non-MS population using CT angiography
K. Agarwal USA

16.55 > 17.05 The CCSVI syndrome: angiographic findings
and Doppler correlation - M. Al-omari Jordan



15.00 > 17.30
WORKSHOP ON ECD FOR DIAGNOSIS OF CCSVI
COORDINATORS P. Zamboni Italy, S. Bastianello Italy

15.00 > 15.20 Anatomy and normal haemodynamics
of cerebral venous return - S. Morovic Croatia

15.30 > 15.50 Assessment of the US equipment
and practical guidelines - K. Marr USA

16.00 > 16.20 Doppler criteria for CCSVI diagnosis
E. Menegatti Italy

16.30 > 17.30 VIDEO demonstration of cases, pitfalls, and open discussion
Clinical instructors: K Marr USA, E Menegatti Italy, M. Mancini Italy



17.30 Meeting Adjourned



20.30 Social Dinner



// 15 March
Bologna, CNR National Research Council,
Via Gobetti 101


8.30 PLENARY SESSION 5
Basic Sciences and Pathology of CCSVI and MS
MODERATORS G. Gabbiani Switzerland, B. Trapp USA

8.30 > 8.45 Hypoperfusion of brain parenchyma in CCSVI
R. Zivadinov USA

8.45 > 9.00 Hypoxia-like aspect of MS B. Trapp USA

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA

9.15 > 9.30 The pathology of the extracranial venous
wall in MS - G. Gabbiani Switzerland

9.30 > 9.45 CCSVI and fluid mechanics: implications
in multiple sclerosis - C.B. Beggs USA



10.00 > 10.20 Coffee Break



10.20 PLENARY SESSION 6
Vascular Mechanisms in Neurological Disorders
MODERATORS C. Iadecola USA, F. Orzi Italy

10.20 > 10.35 Risk factors in vascular dementia
G. Zuliani Italy


10.35 > 10.50 Vascular dysregulation in AD
C. Iadecola USA

10.50 > 11.05 Rare clinical manifestations associated with CCSVI-MS:
extrapyramidal syndrome and normotensive hydrocephalus - F. Salvi Italy

10.05 > 11.20 Seasonality in vascular disorders and preliminary data in MS
R. Manfredini Italy



12.00 PLENARY SESSION 7
Modelling CCSVI Haemodynamics
MODERATORS S. Shepherd UK, C. Franceschi France

12.00 > 12.15 CCSVI and CSF flow dynamics
S. Gianesini Italy

12.15 > 12.30 Cerebral arterial and venous flow measurements
in the neck for patients with MS - W. Feng USA

12.30>12.45 Cervical plethysmography:
is this the ideal screening tool? - P. Zamboni Italy

12.45 > 13.00 Plethysmography and multiple sclerosis:
analysis of novel data - S. Shepherd UK



13.30 > 14.30 Lunch



14.30 PLENARY SESSION 8
Endovascular Aspect and Treatment of CCSVI
MODERATORS M. Dake USA, F. Florio Italy

14.30 > 14.45 BRA.VE DR.E.A.MS: study design of
a multicenter RCT - G. Filippini Italy

14.45 > 15.00 MRI in treatment planning
E. M. Haacke USA

15.00 > 15.15 CCSVI: pathologic findings
and anatomical variants - G. Mansueto Italy

15.15 > 15.30 Integrating intraoperative diagnostic information:
lesson learned from the PREMISE trial - A. N. Siddiqui USA

15.30>15.45 Patients with Chronic Cerebrospinal Venous
Insufficiency Short term results of venous angioplasty.
Single centre Study - M. Zarebinski Poland



16.00 PLENARY SESSION 9
Best Abstracts Presentation - part 2
MODERATORS D. Hubbard USA, F. Schelling Austria

16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland

16.10 > 16.20 Clinical disability and venous vessel pathology
in multiple sclerosis - M. Denislic Slovenia

16.20 > 16.30 Intraluminal and extraluminal extra-cranial
structural and functional venous abnormalities in multiple sclerosis
patients and healthy controls - R. Zivadinov USA

16.30 > 16.40 Prevalence of internal jugular vein abnormalities
on contrast-enhanced 3D T1 GRE MR images in patients with
multiple sclerosis - A. Cieszanowski Poland

16.40 > 16.50 4D Magnetic Resonance Velocity Measurements
in the Internal Jugular Veins - C. J. Elkins USA



17.30 Conclusion
Cece
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Post by Cece »

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA
I googled murine, it means mouse! This is the ccsvi mouse model, with mild but significant impairment of gait.
16.15 > 16.25 BOLD fMRI responses during cognitive tasks
in MS and effects of venoplasty - G. Buracas USA
exciting - do you think they are getting results with the BOLD fMRI?
16.25 > 16.35 A Prospective Analysis of Endovascular
Treatments of CCSVI in MS - M. Mehta USA
Dr. Mehta is presenting!
16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland
OCT - I've forgotten what this is - what could Dr. Simka be finding with OCT in CCSVI?
12.30>12.45 Cervical plethysmography:
is this the ideal screening tool? - P. Zamboni Italy
plethysmography is a neck collar, it's so bizarre, I posted a link to an article on it based on the mention of plethysmography on the poster. If Zamboni is behind it, it's probably genius.
15.30 > 15.45 Carotid artery angioplasty
and stenting following the CREST trial - A. N. Siddiqui USA
treatment of carotid artery stenosis can cause restoration of colors, like what I've experienced; I'm interested in learning more of this
Last edited by Cece on Tue Feb 15, 2011 9:56 pm, edited 1 time in total.
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Post by drsclafani »

Cece wrote:
16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland
OCT - I've forgotten what this is - what could Dr. Simka be finding with OCT in CCSVI?
optical coherence tomography
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Post by Cece »

drsclafani wrote:optical coherence tomography
I used to know what optical coherence tomography was!

here we go:
Optical coherence tomography (OCT) is a new, noninvasive, noncontact, transpupillary imaging technology which can image retinal structures in vivo with a resolution of 10 to 17 microns. Cross-sectional images of the retina are produced using the optical backscattering of light in a fashion analogous to B- scan ultrasonography. The anatomic layers within the retina can be differentiated and retinal thickness can be measured.
16.30 > 17.30 VIDEO demonstration of cases, pitfalls, and open discussion
Clinical instructors: K Marr USA, E Menegatti Italy, M. Mancini Italy
this one sounds fun
15.15 > 15.30 Integrating intraoperative diagnostic information:
lesson learned from the PREMISE trial - A. N. Siddiqui USA
I think Siddiqui was behind the Georgetown trial?
14.15 > 14.30 Iron traffic genetic variants in MS
D. Gemmati Italy
iron traffic genetic variants...?
9.30 > 9.45 Intravascular Ultrasounds
S. Sclafani USA
ivus - this will be a good one
10.00 > 10.15 Fusion imaging technology
P. Zamboni Italy
this came up at iset too, it's the combined mri & doppler ultrasound "fusion" so getting both types of images at the same time.

Cheer, you mentioned this:
I'm thrilled to note that Dr. Gabbiani will be speaking again. He is a vascular professor at the University of Geneva, and has published hundreds of papers-- he studied jugular vein tissue in pwCCSVI and found a collagen shift in the entire vein, not just the area of stenosis. A morphological change which has been connected to artheriosclerosis in arteries, not seen in veins before.
Do you know if that's a collagen shift that is permanent or is it reversible, either in CCSVI or in artheriosclerosis?
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Post by MrSuccess »

this is exceptional . the list of speakers is amazing.

the published presentations will set the medical world on it's ear.

:idea: what is needed is to have a few well respected Neurologists
attend ...... and take notes. :idea:

Plenary Session 9 ....... alone .... is worth the airfare ........








Mr. Success
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Post by ErikaSlovakia »

Cece wrote: 16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland
OCT - I've forgotten what this is - what could Dr. Simka be finding with OCT in CCSVI?
He Cece!
This is my own OCT test done 3 days after the procedure: http://sofista.sk/documents/Erika,%20OC ... towice.jpg
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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Post by Nunzio »

Cece wrote:
drsclafani wrote:optical coherence tomography
I used to know what optical coherence tomography was!

here we go:
Optical coherence tomography (OCT) is a new, noninvasive, noncontact, transpupillary imaging technology which can image retinal structures in vivo with a resolution of 10 to 17 microns. Cross-sectional images of the retina are produced using the optical backscattering of light in a fashion analogous to B- scan ultrasonography. The anatomic layers within the retina can be differentiated and retinal thickness can be measured.
OCT is a technique that can image live tissue similar to what ultrasound does but with much higher resolution.
It is like looking at a pathology slide under the microscope but with live tissue.
The resolution is so great that in patient with MS we can often quantify a thinning of the nerve fiber layer near the optic nerve specially if the patient had optic neuritis in the past and that tissue is only few microns thick.
Here of course they are referring to intravascular OCT and the bottom line is: if you like IVUS you will love Intravascular OCT.
To be applied to the vascular tissue they use infrared wavelength to overcome the opacity of the medium.
Optical Coherence Tomography (OCT) is the Extreme Resolution™ imaging technology for cardiovascular disease diagnosis. LightLab OCT utilizes near-infrared light to create images with 10 times the resolution of Intravascular ultrasound (IVUS). The proprietary LightLab OCT interferometer analyzes reflected light waves to create our extreme resolution Golden Image™ for enhanced diagnosis and treatment decisions.

The bandwidths of infrared light utilized for OCT are far higher than ultrasound, resulting in greatly increased image resolution. In fact, LightLab OCT provides intravascular images with 15 micrometer axial resolution, about twice the size of a red blood cell. Despite providing this extreme resolution LightLab OCT is a radiation-free* imaging medium.
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Post by Nunzio »

Cece wrote:
12.30>12.45 Cervical plethysmography:
is this the ideal screening tool? - P. Zamboni Italy
plethysmography is a neck collar, it's so bizarre, I posted a link to an article on it based on the mention of plethysmography on the poster. If Zamboni is behind it, it's probably genius.
I do not know how you came up with this one.
Plethysmography is the recording of changes of body volume.
It is used to check your lung function or, more interesting for us, the blood flow.
Cervical means neck so they are talking about an instrument that check blood flow in the neck.
Plethysmography is a test used to measure changes in blood flow or air volume in different parts of the body. It may be done to check for blood clots in the arms and legs, or to measure how much air you can hold in your lungs.
Plethysmography is a non-invasive technique for measuring the amount of blood flow present or passing through, an organ or other part of the body. Plethysmography is used to diagnose deep vein thrombosis and arterial occlusive disease.

Plethysmography is used as the sole diagnostic modality for these conditions, or as an initial evaluation to determine the need for venography or arteriography. A variety of plethysmographic techniques are available.
Unless you were talking about this other test::oops:
Penile plethysmography (PPG), or "phallometry", is a controversial type of plethysmograph that measures changes in blood flow in the penis.[
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Post by cheerleader »

Cece wrote:
Cheer, you mentioned this:
I'm thrilled to note that Dr. Gabbiani will be speaking again. He is a vascular professor at the University of Geneva, and has published hundreds of papers-- he studied jugular vein tissue in pwCCSVI and found a collagen shift in the entire vein, not just the area of stenosis. A morphological change which has been connected to artheriosclerosis in arteries, not seen in veins before.
Do you know if that's a collagen shift that is permanent or is it reversible, either in CCSVI or in artheriosclerosis?
The collagen shift in artheriosclerosis can be reversable--if it is due to inflammation (from environmental issues like diet) and disturbed blood flow that can be corrected. If it is due to a genetic condition, like Ehler Danlos disease, it is permanent. The doctors continue to study this. The truth may be that some is congenital, some is situational.

It's quite a line up of speakers...hope someone is able to go and report back to us all.

And as far as your return of vivid color perception, Cece....we need only look to the reduction of diffuse cerebral hypoxia in your brain thanks to Dr. Sclafani's skills....
This study reports the effect of a moderate level of hypoxia on human color discimination. We found a generalized loss of color vision affecting both red-green and blue-yellow discrimination at an altitude of 12,000 feet. Although the residual color discrimination at this altitude was within age-matched, sea-level norms, a statistically significant increase over sea level error scores was measured on the Farnsworth-Munsell 100-Hue test and the Pickford-Nicolson anomaloscope. An analysis of psychophysical and electrophysiological studies indicates that hypoxia acts by depressing retinal ganglion cell activity and that it can affect photopic visual processes as well as scotopic vision. We conclude that studies evaluating man's visual performance at altitude must consider post-receptoral processes.
http://www.springerlink.com/content/u44986g78877w715/


Your brain has been living at high altitude....welcome to sea level! :)
keep healing, we're going to need your energy to help others,
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Post by CuriousRobot »

Nunzio wrote: I do not know how you came up with this one.
Plethysmography is the recording of changes of body volume.
It is used to check your lung function or, more interesting for us, the blood flow.
Cervical means neck so they are talking about an instrument that check blood flow in the neck.
Noninvasive measurement of central venous pressure by neck inductive plethysmography.

http://chestjournal.chestpubs.org/conte ... l.pdf+html

Page four of this document: Plethysmography as neck collar.
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Post by Cece »

CuriousRobot wrote:
Nunzio wrote: I do not know how you came up with this one.
Plethysmography is the recording of changes of body volume.
It is used to check your lung function or, more interesting for us, the blood flow.
Cervical means neck so they are talking about an instrument that check blood flow in the neck.
Noninvasive measurement of central venous pressure by neck inductive plethysmography.

http://chestjournal.chestpubs.org/conte ... l.pdf+html

Page four of this document: Plethysmography as neck collar.
yes - a neck collar contraption that measures blood flow - sorry, I wasn't very clear last night! There are pictures of it in the article CuriousRobot linked, if it's the same as the article we had before, and it is a bizarre looking thing but exciting if it delivers more accurate or reproducible results than the other imaging methods thus far
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Post by Cece »

cheerleader wrote:The collagen shift in artheriosclerosis can be reversable--if it is due to inflammation (from environmental issues like diet) and disturbed blood flow that can be corrected. If it is due to a genetic condition, like Ehler Danlos disease, it is permanent. The doctors continue to study this. The truth may be that some is congenital, some is situational.
Thanks, very interesting, and good motivation to eat and live healthy
It's quite a line up of speakers...hope someone is able to go and report back to us all.
With you out, the only TIMS members that I know of going are DrCumming and drsclafani.
And as far as your return of vivid color perception, Cece....we need only look to the reduction of diffuse cerebral hypoxia in your brain thanks to Dr. Sclafani's skills....
This study reports the effect of a moderate level of hypoxia on human color discimination. We found a generalized loss of color vision affecting both red-green and blue-yellow discrimination at an altitude of 12,000 feet. Although the residual color discrimination at this altitude was within age-matched, sea-level norms, a statistically significant increase over sea level error scores was measured on the Farnsworth-Munsell 100-Hue test and the Pickford-Nicolson anomaloscope. An analysis of psychophysical and electrophysiological studies indicates that hypoxia acts by depressing retinal ganglion cell activity and that it can affect photopic visual processes as well as scotopic vision. We conclude that studies evaluating man's visual performance at altitude must consider post-receptoral processes.
http://www.springerlink.com/content/u44986g78877w715/
Thank you - amazing!!
I wish I'd have done a before-and-after Hue test or Pickford-Nicolson anomaloscope! How validating it would've been to have this measured.

Hypoxia depresses the retinal ganglion cell activity, which affects photopic visual processes and scotopic vision...I am going to have to look some of this up.
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