This Is MS Multiple Sclerosis Community: Knowledge & Support

Scientific programme


// ISNVD Annual Meeting

FERRARA, MARCH 13, 2011 ITALY
Aula Magna, Dipartimento di Scienze Giuridiche
BOLOGNA, MARCH 14-15, 2011 ITALY
CNR National Research Council of Bologna
ECM certificates


// 13 March

Ferrara, Dipartimento di Scienze Giuridiche - Aula Magna,
Corso Ercole I d'Este 47


// 8.30 > 16.30 // ISNVD Consensus Conference
In cooperation with UIA, EVF, UIP, ACP, AAsCP, SICVE, SIAPAV
US Screening for CCSVI. Recommendations for a protocol

EDITORIAL COMMITTEE
CHAIRMAN A. N. Nicolaides Cyprus
CO-CHAIRMAN P. Zamboni Italy (ISNVD representative)
SECRETARY S. Morovic Croatia, E. Menegatti Italy, G. Viselner Italy
FACULTY D. Neuhardt USA (ACP representative), M.B. Griffin UK (EVF representative), A. Cavezzi Italy (UIP representative), B.B. Lee USA (UIA representative), P. Thibault Australia (AAsCP), C. Setacci Italy (SICVE representative), G. Andreozzi Italy (SIAPAV representative), R. Zivadinov USA, K. Marr USA, S. Bastianello Italy (Editor Functional Neurology), S. Sclafani USA, M. Simka Poland, M. Al-Omari Jordan, C. Franceschi France, C.B. Beggs UK, S. Shepperd UK, M. Mancini Italy, P. Cecconi Italy, S. Mc Donald Canada, A. Lagace Canada, A. Stella Italy, A. Scuderi Brasile, V. DeMarin Croatia, O. Maleti Italy, M. Lugli Italy, F. Vic UK, N. Liasis Greece, M. Marinoni Italy, A. Galassi Italy



// 14 March
Bologna, CNR National Research Council,
Via Gobetti 101


8.30 > 9.00 // Congress Opening


9.00 PLENARY SESSION 1
CCSVI Imaging
MODERATORS E. M. Haacke USA, M. Salvatore Italy

9.00 > 9.15 Ultrasounds: data review
S. Bastianello Italy

9.15 > 9.30 Ultrasonographic transit time
M. Mancini Italy

9.30 > 9.45 Intravascular Ultrasounds
S. Sclafani USA

9.45 > 10.00 CT angiography
V. Iaccarino Italy

10.00 > 10.15 Fusion imaging technology
P. Zamboni Italy

10.15 > 10.30 Catheter Venography
R. Galeotti Italy

10.30 > 10.45 The limits of MRV
R. Zivadinov USA



11.15 > 11.30 Coffee Break



11.30 > 12.15
KEYNOTE LECTURE
PRESIDENT P. Zamboni Italy

Neurovascular Mechanisms in Neurodegenerative Diseases
B. Zlokovic USA



12.30 > 13.30 Lunch



13.30 PLENARY SESSION 2
Iron in Neurodegenerative Disorders
MODERATORS R. Zivadinov USA, M. Simka Poland

13.30 > 13.45 Iron and oxidative stress in AD
C. Iadecola USA

13.45 > 14.00 Iron and veins in MS
R. Zivadinov USA

14.00 > 14.15 Mitochondria dysfunction and differentiation of oligodendrocytes.
Is iron a candidate factor? - P. Pinton Italy

14.15 > 14.30 Iron traffic genetic variants in MS
D. Gemmati Italy



14.45 PLENARY SESSION 3
Update on Carotid Surgery and Stroke
In cooperation with the Italian Society for Vascular and Endovascular Surgery (SICVE)

MODERATORS C. Setacci Italy, A. N. Siddiqui USA

14.45 > 15.00 Carotid plaque echolucency and risk of stroke
in carotid stenting - G.M. Biasi Italy

15.00 > 15.15 Serological and morphological markers
of vulnerable carotid plaque - A. Stella Italy

15.15 > 15.30 Open Carotid Surgery in Emergency:
Indication and Technique - F. Mascoli Italy

15.30 > 15.45 Carotid artery angioplasty
and stenting following the CREST trial - A. N. Siddiqui USA



16.15 PLENARY SESSION 4
Best Abstracts Presentation - part 1
MODERATORS G Filippini Italy, R. Galeotti Italy

16.15 > 16.25 BOLD fMRI responses during cognitive tasks
in MS and effects of venoplasty - G. Buracas USA

16.25 > 16.35 A Prospective Analysis of Endovascular
Treatments of CCSVI in MS - M. Mehta USA

16.35 > 16.45 The Role of Three Dimensional Magnetic
Resonance Venography in Confirming of Color Doppler
Ultrasound Findings - N. Liasis Greece

16.45 > 16.55 Evaluating the presence of abnormal venous
vasculature in a non-MS population using CT angiography
K. Agarwal USA

16.55 > 17.05 The CCSVI syndrome: angiographic findings
and Doppler correlation - M. Al-omari Jordan



15.00 > 17.30
WORKSHOP ON ECD FOR DIAGNOSIS OF CCSVI
COORDINATORS P. Zamboni Italy, S. Bastianello Italy

15.00 > 15.20 Anatomy and normal haemodynamics
of cerebral venous return - S. Morovic Croatia

15.30 > 15.50 Assessment of the US equipment
and practical guidelines - K. Marr USA

16.00 > 16.20 Doppler criteria for CCSVI diagnosis
E. Menegatti Italy

16.30 > 17.30 VIDEO demonstration of cases, pitfalls, and open discussion
Clinical instructors: K Marr USA, E Menegatti Italy, M. Mancini Italy



17.30 Meeting Adjourned



20.30 Social Dinner



// 15 March
Bologna, CNR National Research Council,
Via Gobetti 101


8.30 PLENARY SESSION 5
Basic Sciences and Pathology of CCSVI and MS
MODERATORS G. Gabbiani Switzerland, B. Trapp USA

8.30 > 8.45 Hypoperfusion of brain parenchyma in CCSVI
R. Zivadinov USA

8.45 > 9.00 Hypoxia-like aspect of MS B. Trapp USA

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA

9.15 > 9.30 The pathology of the extracranial venous
wall in MS - G. Gabbiani Switzerland

9.30 > 9.45 CCSVI and fluid mechanics: implications
in multiple sclerosis - C.B. Beggs USA



10.00 > 10.20 Coffee Break



10.20 PLENARY SESSION 6
Vascular Mechanisms in Neurological Disorders
MODERATORS C. Iadecola USA, F. Orzi Italy

10.20 > 10.35 Risk factors in vascular dementia
G. Zuliani Italy


10.35 > 10.50 Vascular dysregulation in AD
C. Iadecola USA

10.50 > 11.05 Rare clinical manifestations associated with CCSVI-MS:
extrapyramidal syndrome and normotensive hydrocephalus - F. Salvi Italy

10.05 > 11.20 Seasonality in vascular disorders and preliminary data in MS
R. Manfredini Italy



12.00 PLENARY SESSION 7
Modelling CCSVI Haemodynamics
MODERATORS S. Shepherd UK, C. Franceschi France

12.00 > 12.15 CCSVI and CSF flow dynamics
S. Gianesini Italy

12.15 > 12.30 Cerebral arterial and venous flow measurements
in the neck for patients with MS - W. Feng USA

12.30>12.45 Cervical plethysmography:
is this the ideal screening tool? - P. Zamboni Italy

12.45 > 13.00 Plethysmography and multiple sclerosis:
analysis of novel data - S. Shepherd UK



13.30 > 14.30 Lunch



14.30 PLENARY SESSION 8
Endovascular Aspect and Treatment of CCSVI
MODERATORS M. Dake USA, F. Florio Italy

14.30 > 14.45 BRA.VE DR.E.A.MS: study design of
a multicenter RCT - G. Filippini Italy

14.45 > 15.00 MRI in treatment planning
E. M. Haacke USA

15.00 > 15.15 CCSVI: pathologic findings
and anatomical variants - G. Mansueto Italy

15.15 > 15.30 Integrating intraoperative diagnostic information:
lesson learned from the PREMISE trial - A. N. Siddiqui USA

15.30>15.45 Patients with Chronic Cerebrospinal Venous
Insufficiency Short term results of venous angioplasty.
Single centre Study - M. Zarebinski Poland



16.00 PLENARY SESSION 9
Best Abstracts Presentation - part 2
MODERATORS D. Hubbard USA, F. Schelling Austria

16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland

16.10 > 16.20 Clinical disability and venous vessel pathology
in multiple sclerosis - M. Denislic Slovenia

16.20 > 16.30 Intraluminal and extraluminal extra-cranial
structural and functional venous abnormalities in multiple sclerosis
patients and healthy controls - R. Zivadinov USA

16.30 > 16.40 Prevalence of internal jugular vein abnormalities
on contrast-enhanced 3D T1 GRE MR images in patients with
multiple sclerosis - A. Cieszanowski Poland

16.40 > 16.50 4D Magnetic Resonance Velocity Measurements
in the Internal Jugular Veins - C. J. Elkins USA



17.30 Conclusion

9.00 > 9.15 A murine model of CCSVI is associated with
mild but significant impairment of gait as assessed by
neurobehavioral testing - P. Thanaporn USA

16.15 > 16.25 BOLD fMRI responses during cognitive tasks
in MS and effects of venoplasty - G. Buracas USA

16.25 > 16.35 A Prospective Analysis of Endovascular
Treatments of CCSVI in MS - M. Mehta USA

16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland

12.30>12.45 Cervical plethysmography:
is this the ideal screening tool? - P. Zamboni Italy

15.30 > 15.45 Carotid artery angioplasty
and stenting following the CREST trial - A. N. Siddiqui USA

OCT - I've forgotten what this is - what could Dr. Simka be finding with OCT in CCSVI?

optical coherence tomography

Optical coherence tomography (OCT) is a new, noninvasive, noncontact, transpupillary imaging technology which can image retinal structures in vivo with a resolution of 10 to 17 microns. Cross-sectional images of the retina are produced using the optical backscattering of light in a fashion analogous to B- scan ultrasonography. The anatomic layers within the retina can be differentiated and retinal thickness can be measured.

16.30 > 17.30 VIDEO demonstration of cases, pitfalls, and open discussion
Clinical instructors: K Marr USA, E Menegatti Italy, M. Mancini Italy

15.15 > 15.30 Integrating intraoperative diagnostic information:
lesson learned from the PREMISE trial - A. N. Siddiqui USA

14.15 > 14.30 Iron traffic genetic variants in MS
D. Gemmati Italy

9.30 > 9.45 Intravascular Ultrasounds
S. Sclafani USA

10.00 > 10.15 Fusion imaging technology
P. Zamboni Italy

I'm thrilled to note that Dr. Gabbiani will be speaking again. He is a vascular professor at the University of Geneva, and has published hundreds of papers-- he studied jugular vein tissue in pwCCSVI and found a collagen shift in the entire vein, not just the area of stenosis. A morphological change which has been connected to artheriosclerosis in arteries, not seen in veins before.

16.00 > 16.10 Optical coherence tomography findings in patients
with chronic cerebrospinal venous insufficiency - M. Simka Poland
OCT - I've forgotten what this is - what could Dr. Simka be finding with OCT in CCSVI?

I used to know what optical coherence tomography was!

here we go:

Optical Coherence Tomography (OCT) is the Extreme Resolution™ imaging technology for cardiovascular disease diagnosis. LightLab OCT utilizes near-infrared light to create images with 10 times the resolution of Intravascular ultrasound (IVUS). The proprietary LightLab OCT interferometer analyzes reflected light waves to create our extreme resolution Golden Image™ for enhanced diagnosis and treatment decisions.

The bandwidths of infrared light utilized for OCT are far higher than ultrasound, resulting in greatly increased image resolution. In fact, LightLab OCT provides intravascular images with 15 micrometer axial resolution, about twice the size of a red blood cell. Despite providing this extreme resolution LightLab OCT is a radiation-free* imaging medium.

I do not know how you came up with this one.
Plethysmography is the recording of changes of body volume.
It is used to check your lung function or, more interesting for us, the blood flow.
Cervical means neck so they are talking about an instrument that check blood flow in the neck.


Unless you were talking about this other test::oops:

Cheer, you mentioned this:

Do you know if that's a collagen shift that is permanent or is it reversible, either in CCSVI or in artheriosclerosis?

This study reports the effect of a moderate level of hypoxia on human color discimination. We found a generalized loss of color vision affecting both red-green and blue-yellow discrimination at an altitude of 12,000 feet. Although the residual color discrimination at this altitude was within age-matched, sea-level norms, a statistically significant increase over sea level error scores was measured on the Farnsworth-Munsell 100-Hue test and the Pickford-Nicolson anomaloscope. An analysis of psychophysical and electrophysiological studies indicates that hypoxia acts by depressing retinal ganglion cell activity and that it can affect photopic visual processes as well as scotopic vision. We conclude that studies evaluating man's visual performance at altitude must consider post-receptoral processes.

I do not know how you came up with this one.
Plethysmography is the recording of changes of body volume.
It is used to check your lung function or, more interesting for us, the blood flow.
Cervical means neck so they are talking about an instrument that check blood flow in the neck.

Noninvasive measurement of central venous pressure by neck inductive plethysmography.

http://chestjournal.chestpubs.org/conte ... l.pdf+html

Page four of this document: Plethysmography as neck collar.

The collagen shift in artheriosclerosis can be reversable--if it is due to inflammation (from environmental issues like diet) and disturbed blood flow that can be corrected. If it is due to a genetic condition, like Ehler Danlos disease, it is permanent. The doctors continue to study this. The truth may be that some is congenital, some is situational.

It's quite a line up of speakers...hope someone is able to go and report back to us all.

And as far as your return of vivid color perception, Cece....we need only look to the reduction of diffuse cerebral hypoxia in your brain thanks to Dr. Sclafani's skills....


http://www.springerlink.com/content/u44986g78877w715/