This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Mon May 20, 2013 11:31 pm

View unanswered posts | View active topics


Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]



Post new topic Reply to topic  Page 3 of 5
  [ 68 posts ]  Go to page Previous  1, 2, 3, 4, 5  Next
  Print view Previous topic | Next topic 
Author Message
Jugular
 Post subject:
PostPosted: Sat Feb 19, 2011 10:00 am 
Offline
Family Elder
User avatar

Joined: Mon Dec 21, 2009 4:00 pm
Posts: 375
Cece wrote:
not Zamboni! :D
Thanaporn is our mouse doctor.
I was referencing a quote from Dr. Zamboni when he was asked about the lack of a mouse model. You probably knew that. Still, to me, this is one mighty mouse because if this pans out it could really turn the tables on the neurologists. That mouse, walking with its little limp, is one of us. I'd like to buy that little mouse a beer. Or whatever it is that mice like
Top
 Profile  
 
Cece
 Post subject:
PostPosted: Sat Feb 19, 2011 10:15 am 
Offline
Family Elder

Joined: Mon Jan 04, 2010 4:00 pm
Posts: 8506
Jugular wrote:
Cece wrote:
not Zamboni! :D
Thanaporn is our mouse doctor.
I was referencing a quote from Dr. Zamboni when he was asked about the lack of a mouse model. You probably knew that. Still, to me, this is one mighty mouse because if this pans out it could really turn the tables on the neurologists. That mouse, walking with its little limp, is one of us. I'd like to buy that little mouse a beer. Or whatever it is that mice like

Yes, and I thought it was quite witty.
Wittier than my response, alas.
A cheese beer for the mouse!! Along with some cheese cheers.
Top
 Profile  
 
Jugular
 Post subject:
PostPosted: Sat Feb 19, 2011 12:08 pm 
Offline
Family Elder
User avatar

Joined: Mon Dec 21, 2009 4:00 pm
Posts: 375
Cheers to you too!

:D

Image[/img]
Top
 Profile  
 
Shannon
 Post subject:
PostPosted: Sat Feb 19, 2011 7:45 pm 
Offline
Family Elder

Joined: Mon Sep 28, 2009 3:00 pm
Posts: 148
ROFLOL...see how they run, or stumble, or fall.

I've known Zamboni was a Nursery Rhyme doctor all along! After all, he's Italian. You can trust those Italians! They're not American, after all, therefore they must be right out of Mother Goose.

The "specialist" that they sent me too acted very much like he believed this when I tried to discuss it. he was like, "Oh, is that thing that came out of Italy...some Dr. ZAMBONI?" He said it like he could have been asking if I was talking about Humpty Dumpty!
Top
 Profile  
 
codefellow
PostPosted: Sun Feb 20, 2011 6:18 pm 
Offline
Family Elder
User avatar

Joined: Tue Nov 18, 2008 4:00 pm
Posts: 120
I was just joking about the whole blind mice thing, then it occurred to me....

One of the first symptoms of MS is sometimes foot drop, as in our mouse. (I wonder if this was or will be objectively verified. Even the researcher says it is barely perceptible).

But frequently another beginning symptom of MS is Optic Neuritis!

Not since Mickey and Mighty has a mouse had such an interested audience!

:)
Top
 Profile  
 
codefellow
PostPosted: Sun Feb 20, 2011 6:22 pm 
Offline
Family Elder
User avatar

Joined: Tue Nov 18, 2008 4:00 pm
Posts: 120
codefellow wrote:

Even the researcher says it is barely perceptible



Sorry, I do NOT know where that came from, cannot cite it. Please forgive inaccurate information here, I got overly excited. :oops:
Top
 Profile  
 
pairOdime
 Post subject:
PostPosted: Sun Feb 20, 2011 6:27 pm 
Offline
Family Elder

Joined: Sun Dec 05, 2010 4:00 pm
Posts: 129
Location: WV
It was noted as......
Quote:
mild but significant impairment of gait as assessed by neurobehavioral testing

_________________
It's a paradigm shift
Top
 Profile  
 
codefellow
 Post subject:
PostPosted: Sun Feb 20, 2011 10:56 pm 
Offline
Family Elder
User avatar

Joined: Tue Nov 18, 2008 4:00 pm
Posts: 120
pairOdime wrote:
It was noted as......
Quote:
mild but significant impairment of gait as assessed by neurobehavioral testing


But what do those phrases REALLY mean?

1) "mild but significant"
2) "as assessed by neurobehavorial testing"

Cece, cheerleader, anyone? Inquiring minds want to know!

:?
Top
 Profile  
 
1eye
 Post subject:
PostPosted: Mon Feb 21, 2011 12:21 am 
Offline
Family Elder
User avatar

Joined: Wed Mar 17, 2010 4:00 pm
Posts: 2564
Location: Kanata, Ontario, Canada
You know, if you give a blind mouse a white cane, he may ask you for a white walker, and then a... OMG... wheelchair, and who knows where that may lead!

Garb for Patients Without Patience: black johnny-shirts, white canes, white mouse-ears. Sunglasses optional. Blue and red tail-ribbons.

_________________
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
Top
 Profile  
 
se1956
 Post subject:
PostPosted: Mon Feb 21, 2011 12:59 am 
Offline
Family Member
User avatar

Joined: Wed Dec 02, 2009 4:00 pm
Posts: 65
Usually this should mean, that the statistical data of some gait test show differences that are not explainable just by chance - using mathematical analysis.

At the onset of MS there are only mild impairments too. The gait is not as smooth as normal, may be some stiffness in the legs, some minor balancing issues...

R.
Top
 Profile  
 
bigfoot14
 Post subject:
PostPosted: Mon Feb 21, 2011 1:50 pm 
Offline
Family Elder
User avatar

Joined: Mon Nov 30, 2009 4:00 pm
Posts: 110
Location: State of confusion (Illinois)
Patientx posted this on another site

http://www.ncbi.nlm.nih.gov/pmc/article ... 41/?page=1

this study used rats, and lasted one week, I wonder what the results would be if the study went on for say 3-4 months
Top
 Profile  
 
cheerleader
 Post subject:
PostPosted: Mon Feb 21, 2011 2:31 pm 
Offline
Family Elder
User avatar

Joined: Mon Sep 10, 2007 3:00 pm
Posts: 4676
Location: southern California
bigfoot14 wrote:
Patientx posted this on another site

http://www.ncbi.nlm.nih.gov/pmc/article ... 41/?page=1

this study used rats, and lasted one week, I wonder what the results would be if the study went on for say 3-4 months


Thanks for posting that link, bigfoot. I had not seen that study, since patient didn't link it on TIMS. Wonder why? Interesting clinical conclusion:
Bilateral IJV ligation could create not only venous congestion and other factors such as hypoxia and hypotension, it could produce a "fragile situation in the brain and then enhance brain damage."

We have to wait for the full paper, folks. All I know from my conversations with the Stanford docs is that they've been working on this about a year, followed the mice for a long time (months) and they saw white matter lesions and motor issues develop. March is almost here....hang in there!
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS


Top
 Profile  
 
Billmeik
 Post subject:
PostPosted: Sun Feb 27, 2011 7:27 am 
Offline
Family Elder
User avatar

Joined: Fri Nov 27, 2009 4:00 pm
Posts: 690
Quote:
and they saw white matter lesions and motor issues develop



The lesions! I would love to hear that confirmed. Is this the putnam replication we've been waiting for? A few weeks waiting to read this whole paper will tell. I think Ill postpone my appt at pacific interventionalists until then.
I thought the post about the mouses placebo response was hilarious!
Top
 Profile  
 
Cece
 Post subject:
PostPosted: Sun Feb 27, 2011 10:12 am 
Offline
Family Elder

Joined: Mon Jan 04, 2010 4:00 pm
Posts: 8506
I am hesitant to get too excited until we have the paper itself. I remember everyone thinking the BNAC results were going to be at 95% and it set us up for disappointment when it came in at 56% or 65%, around this time last year. If it turns out to be true that the CCSVI mouse model gets white matter lesions, then that is a slam dunk, well done Dr. Thanaporn.

Bill, the presentation may be just a presentation, no paper at all yet.
Top
 Profile  
 
PCakes
 Post subject:
PostPosted: Sun Feb 27, 2011 10:50 am 
Offline
Family Elder
User avatar

Joined: Sun Dec 13, 2009 4:00 pm
Posts: 849
Location: Canada
Cece wrote:
If it turns out to be true that the CCSVI mouse model gets white matter lesions, then that is a slam dunk...


..those points were already on the scoreboard.. good move picking up the mice in that last draft..;)
Quote:
Recall 1935 work on venous obstruction
Tracey Putnam, Boston City Hospital, y , y p , developed an experimental dog model of venous obstruction to study MS. His work supports the recent rediscovery of this concept by Dr Paolo Zamboni of Italy Dr. Italy.
He stated:

"The similarity between such lesions y and many of those seen in cases of multiple sclerosis in man is so striking that the conclusion appears almost inevitable that venular obstruction is the essential immediate antecedent to the formation of typical sclerotic plaques." plaques "
Putnam (1935). Studies in multiple sclerosis: encephalitis and sclerotic plaques produced by venular obstruction. Archives of Neurology and Psychiatry. 33: 929-940.
Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  Page 3 of 5
  [ 68 posts ]  Go to page Previous  1, 2, 3, 4, 5  Next

Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

All times are UTC - 8 hours [ DST ]

Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. Possible animal model for MS by inducing CCSVI ?

ozarkcanoer

6

1386

Mon Nov 02, 2009 9:21 am

cheerleader View the latest post

There are no new unread posts for this topic. mouse models for CVI

Cece

6

1261

Tue Jul 06, 2010 2:45 am

CureOrBust View the latest post

There are no new unread posts for this topic. tPA mouse research could help pwCCSVI

Cece

5

340

Mon Jul 23, 2012 8:57 am

Cece View the latest post

There are no new unread posts for this topic. New Disease Model for MS

[ Go to pageGo to page: 1, 2, 3 ]

Direct-MS

40

3979

Fri Feb 04, 2011 7:52 pm

gauchito View the latest post

There are no new unread posts for this topic. Microvascular Hypercoagulability Model for MS

[ Go to pageGo to page: 1, 2, 3 ]

North52

33

3614

Sat Nov 13, 2010 9:09 pm

Johnson View the latest post

 


Who is online

Users browsing this forum: No registered users

You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to: