MarkW wrote:The current mouse model for MS (EAE) has misled researchers for about 50 years so why are folks so excited about a mouse model for CCSVI syndrome ??? I truely hope that vascular researchers do not waste 50 years on a new mouse model.
MS is far more complex than a mouse model could possibly be, in my seldom humble opinion.
Some postings were very funny but please treat any mouse model of MS only as a joke.
CuriousRobot wrote:If you notice, EAE is good thinking but backwards. Also, animal studies are a huge part of medicine, they are so standard, they can't be disregarded.
Billmeik wrote:This wouldn't be an animal 'model' but this mouse would have real Ms. Lesions plus a symptom. Revolutionary.
All other factors, genetics, vitamin d, would be disproven. MS ican be caused caused by ccsvi alone.
The basic research is focused on induced pluripotential stem cells (iPSCs) for vascular regeneration. We are developing cell-permeant proteins and new chemical entities for nuclear reprogramming, and for differentiation of iPSCs into endothelial cells. Human iPSC-derived endothelial cells are currently being tested in our murine model of PAD.
MarkW wrote:I suggest folks find out about EAE. It does NOT create MS in mice rather it gives mice 'MS like' lesions, not MS. Most of you disagree with me, that's life. I suggest the mouse modellers at Stanford think very carefully about their model and read the critics of EAE before spending too many years creating CCSVI syndrome in mice which looks like MS.
Group think is sometimes dangerous.
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